Evaluation of ᾱṅg徱 ҳṛt in Behavioral Despair with Animals
Journal name: Ancient Science of Life
Original article title: Experimental Evaluation of ᾱṅg徱 ҳṛt in Behavioral Despair Using Animal Models
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
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Poonam Ashish Gupte, Jayshree Dawane, Asmita Ashish Wele
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Experimental Evaluation of ᾱṅg徱 ҳṛt in Behavioral Despair Using Animal Models
Year: 2016
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Depression is increasingly recognized as a significant mental health issue, affecting a substantial portion of the population and leading to a high rate of suicides. Traditional antidepressant medications only provide relief to a limited number of patients while often presenting side effects. Consequently, there is an urgent need to explore alternative treatments, such as those found in Ayurveda. This study aims to evaluate the antidepressant activity of ᾱṅg徱 ҳṛt (HG), an Ayurvedic formulation, using animal models to assess its efficacy comprehensively.
Effectiveness of ᾱṅg徱 ҳṛt
The study utilized two models, the Tail Suspension Test (TST) and the Forced Swim Test (FST), to measure the antidepressant effects of HG. Various doses of HG were administered to Swiss albino mice and Wistar albino rats over a period of 21 days. Results indicated that HG significantly reduced the duration of immobility in TST and increased the number of rotations in the FST, suggesting its effectiveness in alleviating depressive-like behaviors. Notably, the standard dosage of HG produced outcomes comparable to the established antidepressant, Imipramine hydrochloride. The findings imply that the active compounds in HG could positively influence neurotransmitter levels, which are critical in managing depressive symptoms.
Conclusion
The findings of this study support the potential of ᾱṅg徱 ҳṛt as an effective antidepressant formulation, displaying significant activity similar to conventional drugs but with a natural basis. Given the growing concern regarding the side effects of modern psychiatric medications, integrating Ayurvedic solutions like HG into treatment paradigms may provide a beneficial alternative for managing depression. Further clinical research is warranted to explore the full therapeutic potential of this Ayurvedic formulation and establish its efficacy in human subjects.
FAQ section (important questions/answers):
What is the main focus of the study on ᾱṅg徱 ҳṛt?
The study evaluates the antidepressant activity of ᾱṅg徱 ҳṛt in animal models, particularly using the Tail Suspension Test (TST) and Forced Swim Test (FST) to assess its effects on behavior resembling depression.
What are the traditional uses of ᾱṅg徱 ҳṛt in Ayurveda?
ᾱṅg徱 ҳṛt is traditionally believed to pacify conditions like Գ岹 (psychosis) and 貹 (epilepsy), and is hypothesized to also alleviate depression, indicated by symptoms of վṣād.
What were the findings related to the dosage of ᾱṅg徱 ҳṛt?
The results showed that ᾱṅg徱 ҳṛt exhibited significant antidepressant effects at specific doses, particularly at 0.1 g/20 g for TST and 0.72 g/200 g for FST, comparable to the standard drug Imipramine.
How was the experiment conducted to test ᾱṅg徱 ҳṛt?
The experiment used a comparative preclinical study design with Swiss albino mice and Wistar albino rats, assessing behavior changes over a 21-day period after administering ᾱṅg徱 ҳṛt, Imipramine, or controls.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of ᾱṅg徱 ҳṛt in Behavioral Despair with Animals�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of the article, 'drug' refers to substances used in the prevention, diagnosis, cure, or treatment of diseases. It particularly highlights the potential antidepressant properties of ᾱṅg徱 ҳṛt as a drug derived from Ayurvedic practices, contrasting it with conventional pharmacological agents, which often have side effects.
2) Ghi (Ghee):
'Ghee' is clarified butter known for its significance in Ayurvedic medicine. It's used as a vehicle for delivering medicinal herbs in formulations and possesses properties that are believed to nourish the brain and enhance absorption of the active ingredients, making it critical in the preparation of ᾱṅg徱 ҳṛt.
3) Activity:
'Activity' refers to the effectiveness of ᾱṅg徱 ҳṛt in demonstrating antidepressant effects as measured in animal models. In pharmacological studies, the term often reflects the biological or therapeutic response of the drug when tested against specific conditions like depression.
4) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient Indian system of medicine emphasizing balance among body, mind, and spirit. This holistic approach plays a vital role in understanding the relevance of traditional remedies such as ᾱṅg徱 ҳṛt, which seeks to address mental health through natural means and balance of the body's doshas.
5) Pharmacology:
'Pharmacology' is the branch of medicine concerned with the study of drug action. The article references experimental evaluation of ᾱṅg徱 ҳṛt in animal models to explore its pharmacological properties and antidepressant actions, linking traditional remedies with modern scientific investigation.
6) Ghrita (Ghrta):
Similar to 'Ghrita', 'ҳṛt' refers to ghee with particular relevance in Ayurvedic formulations. Emphasizing its medicinal qualities, the term highlights the ingredient's role as a crucial component in enhancing therapeutic efficacy in conditions treated with ᾱṅg徱 ҳṛt.
7) Sharman (Sarma, Sharma, Sarman):
'Sharma' refers to a common surname in India but may also allude to the author or an influential figure in Ayurvedic practices or research cited in the article. His contributions could enhance the credibility of the study's findings.
8) Depression:
'Depression' denotes a mood disorder characterized by persistent sadness and loss of interest, impacting an individual's daily functioning. The research aims to explore the antidepressant properties of ᾱṅg徱 ҳṛt in alleviating depressive symptoms in animal models, underscoring the need for alternative treatments.
9) Hingvadi:
'Hingvadi' refers to the formulation ᾱṅg徱, which is asserted in the article as having therapeutic properties. The study promotes the relevance of ancient wisdom in addressing modern mental health concerns, particularly depression.
10) Sauvarcala:
'Sauvarcala' is black salt, an ingredient in the formulation of ᾱṅg徱 ҳṛt. It is valued for its potential health benefits in Ayurveda, including enhancing digestion and balancing doshas, and helping the overall effectiveness of the herbal remedy.
11) Nighantu (Nighamtu):
'Nighantu' refers to traditional texts cataloging medicinal plants and their uses in Ayurveda. The reference to it in the article signifies the importance of authoritative sources in justifying the use of specific ingredients in formulating ᾱṅg徱 ҳṛt.
12) Lavana:
'ṇa' denotes salt in Sanskrit. Its inclusion as an ingredient in Ayurvedic formulations enhances flavor and health benefits, with implications for digestion and nourishment, contributing to the overall effectiveness of preparations like ᾱṅg徱 ҳṛt.
13) Water:
'Water' serves as a universal solvent and is essential in the context of extracting compounds from herbs and administering in experiments. Its presence ensures the correct consistency and delivery of active ingredients in Ayurvedic formulations for therapeutic efficacy.
14) Cow urine (Cow's urine):
'Cow urine' holds a significant place in Ayurveda for its purported medicinal properties. In the preparation of ᾱṅg徱 ҳṛt, it may enhance therapeutic efficacy through its bioactive compounds, supporting the treatment of neurological and psychological conditions.
15) Bhavaprakashanighantu (Bhavaprakasanighantu, Bhavaprakasha-nighantu):
'Bhavaprakasha-nighantu' is an authoritative Ayurvedic text cataloging medicinal plants. Its mention in the article highlights the foundational principles of herbal medicine critical for validating the use of ingredients in the formulation of traditional remedies like ᾱṅg徱 ҳṛt.
16) Psychosis:
'Psychosis' refers to a mental health condition characterized by impaired thoughts and emotions. The connection to ᾱṅg徱 ҳṛt in the article establishes its potential use in treating psychotic disorders, linking ancient knowledge to modern psychiatric understanding.
17) Vagbhata:
'Vagbhata' was an esteemed ancient scholar and Ayurvedic practitioner. His works contribute to the understanding of Ayurvedic principles and formulations such as ᾱṅg徱 ҳṛt, underscoring the relevance of traditional wisdom in contemporary medical practices.
18) Hingu (Himgu):
'ᾱṅg', or giant fennel (Ferula narthex), is a key ingredient in ᾱṅg徱 ҳṛt known for its medicinal properties. Its inclusion in the formulation signifies its role in addressing mood disorders and enhancing overall well-being according to Ayurvedic principles.
19) Pippali (Pippalin):
'ʾ貹ī' is long pepper (Piper longum), an herb revered in Ayurveda for its warming and therapeutic qualities. Its presence in ᾱṅg徱 ҳṛt suggests its role in enhancing the effectiveness of treatments for psychological disorders through its potential pharmacological actions.
20) Siddha:
'Siddha' refers to a traditional Indian system of medicine akin to Ayurveda. Mentioning it in the context of ᾱṅg徱 ҳṛt indicates the interdisciplinary nature of ancient medicinal practices aiming to address complex health issues holistically.
21) Unmada:
'Գ岹' is a Sanskrit term often translated as mental illness or psychosis in Ayurveda. Its relation to the article emphasizes ᾱṅg徱 ҳṛt's relevance in treating psychological conditions and aligns ancient medicinal texts with contemporary psychiatric terminology.
22) Marica:
'ī' refers to black pepper (Piper nigrum), an important ingredient in ᾱṅg徱 ҳṛt. It contributes to the formulation's warming properties and enhances digestion, thereby supporting the remedy's effectiveness against mood disorders in Ayurvedic treatments.
23) Visada (Vishada, Visha-da):
'վṣād' refers to dejection or sorrow in Sanskrit and is associated with premonitory symptoms of depression. Its inclusion in the discussion of ᾱṅg徱 ҳṛt highlights the herb's potential in alleviating sadness and improving emotional well-being.
24) Shunthi (Sunthi, Sumthi, Shumthi):
'Śṇṭ' refers to ginger (Zingiber officinale), known for its medicinal properties, including anti-inflammatory effects. Its role in ᾱṅg徱 ҳṛt underscores the formulation's comprehensive approach to treating mental health issues, emphasizing both physical and psychological benefits.
25) Dhatu:
'ٳٳ' refers to the bodily tissues in Ayurveda, foundational for understanding health and disease. The mention of dhātu indicates a comprehensive view of wellness in the context of ᾱṅg徱 ҳṛt, linking physical and mental health functions.
26) Dosha (Dosa):
'ٴṣa' represents the three fundamental energies (ٲ, Pitta, and Kapha) in Ayurveda that govern physiological and psychological states. The balance of doshas plays a crucial role in health, guiding the formulation and application of ᾱṅg徱 ҳṛt in treating mental disorders.
27) Rasashastra (Rasa-shastra, Rasasastra):
'Rasashastra' is a branch of Ayurveda focused on the medicinal use of metals, minerals, and herbal drugs. Its connection to ᾱṅg徱 ҳṛt addresses the need for understanding various treatment modalities and enhancing safety in traditional medicinal practices.
28) Bhaishajya (Bhaisajya):
'Bhaishajya' denotes the concept of medicine in Ayurveda. Its relevance in the article highlights the role of phytochemicals and medications like ᾱṅg徱 ҳṛt in addressing mental health conditions through ancient Ayurvedic wisdom.
29) Ashtanga (Astanga, Ashtan-anga):
'Ashtanga' refers to an eightfold path in Ayurveda dealing with holistic health principles. Mentioning it signifies a comprehensive approach to understanding mental health and the multifaceted methods inherent in formulating remedies like ᾱṅg徱 ҳṛt.
30) Kalpana:
'貹' is the act of preparation or formulation in Ayurveda. It emphasizes the intricate processes involved in crafting remedies like ᾱṅg徱 ҳṛt, ensuring therapeutic efficacy through precise ingredient selection and preparation methods.
31) Anxiety:
'Anxiety' pertains to a mental health disorder characterized by excessive worry or fear. Its mention relates to the potential effectiveness of ᾱṅg徱 ҳṛt in mitigating anxiety symptoms as part of a broader exploration of its antidepressant properties.
32) Sneha:
'Sneha' means oleaginous substances in Ayurveda, important for nutrient absorption and connecting with traditional preparations. Ghee (ҳṛt) serves as a sneha base in formulations, enhancing the therapeutic efficacy of ᾱṅg徱 ҳṛt.
33) Salt (Salty):
'Salt' enhances flavor and serves physiological roles in the body. In the context of the article, it signifies its incorporation in formulations like ᾱṅg徱 ҳṛt, contributing to overall therapeutic effectiveness through balancing bodily humors.
34) Post:
'Post' denotes the period following an event. In the article, it can refer to the post-treatment evaluations of mood and behavioral changes observed in animal models after administration of ᾱṅg徱 ҳṛt.
35) Mud:
'Mood' refers to a temporary state of mind or feeling. The research focuses on the influence of ᾱṅg徱 ҳṛt on mood regulation, exploring its potential as an antidepressant to improve emotional well-being.
36) Zingiber officinale:
'Zingiber officinale' is the scientific name for ginger. Its inclusion in ᾱṅg徱 ҳṛt signifies its importance in Ayurvedic formulations for its health benefits, including its potential antidepressant and anti-inflammatory properties.
37) Piper longum:
'Piper longum' is recognized as long pepper. Its presence in ᾱṅg徱 ҳṛt enhances its effectiveness in treating various conditions, aligning with the Ayurvedic approach to utilizing synergistic actions of herbs for improving mental health.
38) Pharmacological:
'Pharmacological' relates to the study of drug action and effects. The article examines the pharmacological activities of ᾱṅg徱 ҳṛt, using animal models to evaluate its antidepressant properties in comparison to established pharmaceuticals.
39) Transformation (Transform, Transforming):
'Transformation' refers to the metabolic processes that convert substances in the body. In Ayurvedic practice, the term relates to how food and medicine are metabolized into essential bodily substances, affecting overall health and healing.
40) Sutrasthana (Sutra-sthana):
'Sutrasthana' is a part of Ayurvedic texts outlining medical principles. Its mention reinforces the foundational knowledge used in formulating and understanding the medicinal properties of herbs like those found in ᾱṅg徱 ҳṛt.
41) Majjadhatu (Majja-dhatu):
'Ѳ-ٳ' refers to the nervous tissue or marrow in Ayurveda, essential for mental functions. The article discusses its connection to ᾱṅg徱 ҳṛt's effectiveness in treating mental health issues through nourishing vital tissues.
42) Kaphadosha (Kaphadosa, Kapha-dosha):
'-ṣa' is one of the three doshas, governing bodily structure and immune response. Its imbalance can lead to depressive symptoms, and understanding this linkage aids in addressing mental health conditions through formulations like ᾱṅg徱 ҳṛt.
43) Kushmandi (Kusmandi, Kushmamdi):
'Kushmandi' refers to a type of medicinal preparation in Ayurveda, related to mental health treatments. Mentioning it emphasizes the diversity of Ayurvedic formulations that aim to support psychological well-being and treat ailments like depression.
44) Knowledge:
'Knowledge' pertains to understanding and information acquired through experience or education. In Ayurveda, it emphasizes the importance of both traditional practices and scientific studies in advancing therapeutic approaches like those utilized in ᾱṅg徱 ҳṛt.
45) Apasmara:
'貹' refers to epilepsy in Ayurveda, highlighting the breadth of neurological disorders that ᾱṅg徱 ҳṛt may address. It reflects the formulation's potential in managing conditions characterized by mental instability or disorders.
46) Epilepsy:
'Epilepsy' is a disorder characterized by recurrent seizures, representing a significant area of concern in mental health. The article connects ᾱṅg徱 ҳṛt to potential treatments for epilepsy, showing the formulation's versatility in managing various neurological conditions.
47) Hridaya (Hrdaya):
'Hridaya' refers to the heart in Sanskrit, symbolizing emotional intelligence and health in Ayurveda. Its connection to mental health emphasizes the need for comprehensive approaches to emotional well-being, as represented by formulations like ᾱṅg徱 ҳṛt.
48) Gomutra (Go-mutra):
'Ҵdzūٰ' indicates cow urine, which holds a significant place in Ayurvedic medicine for its purported health benefits. Its inclusion in formulations like ᾱṅg徱 ҳṛt suggests a holistic approach to enhancing therapeutic efficacy.
49) Triguna (Tri-guna):
'հṇa' refers to the three fundamental qualities (Sattva, Rajas, and Tamas) influencing human behavior and mental states. Understanding triguṇa is crucial for Ayurvedic practitioners, especially in managing mood disorders through formulations like ᾱṅg徱 ҳṛt.
50) Science (Scientific):
'Science' refers to the systematic study of the natural world through observation and experimentation. The article bridges ancient Ayurvedic practices and modern scientific methodologies, validating traditional remedies like ᾱṅg徱 with empirical evidence.
51) Brahmi:
'Brahmi' is an Ayurvedic herb known for its cognitive enhancing properties. Its relevance in the context of the article signifies the exploration of various herbs in holistic treatments for mental health and cognitive function.
52) Kapha:
'Kapha' refers to one of the three doshas in Ayurveda associated with structure and stability. An understanding of kapha is essential for diagnosing imbalance that may lead to depression, emphasizing the formulation's role in restoring mental harmony.
53) Majja:
'Ѳ' denotes fatty tissue or nervous substance, significant in Ayurveda for mental health. Its inclusion underscores the formulation's goal of healing through nurturing essential tissues involved in emotional and cognitive well-being.
54) Shri (Sri, Sr):
'Shree' is a term of respect and honor often used before a name. When associated with traditional texts or scholars, it elevates the value and significance of the teachings in Ayurveda and their implications for health.
55) Rasa (Rasha):
'Rasa' refers to the taste or essence of food and drugs in Ayurveda, signifying its influence on digestion and health. Understanding rasa is crucial for formulating remedies like ᾱṅg徱 ҳṛt to ensure proper therapeutic effects.
56) Vata:
'ٲ' is one of the three doshas controlling movement and physiological function. In traditional contexts, balancing ٲ is vital for emotional stability, linking its understanding to the overall approach of ᾱṅg徱 ҳṛt in treating mood disorders.
57) Brahmighrita (Brahmighrta, Brahmi-ghrita):
'Brahmi-ghrita' is a specific Ayurvedic preparation that combines Brahmi (Bacopa monnieri) with ghee. Its mention signifies the exploration of various formulations and their unique benefits in treating cognitive decline and mental health issues.
58) Prajnaparadha (Prajna-paradha):
'ʰñ貹' translates to intellectual offenses or misdeeds in Ayurveda, highlighting the cognitive impairments leading to emotional disturbances. Its mention in the article underscores the need for formulations that nurture mental faculties like those in ᾱṅg徱 ҳṛt.
59) Phytochemical:
'Phytochemical' refers to bioactive compounds found in plants with beneficial effects on health. The relevance in the article emphasizes the properties of herbal ingredients in ᾱṅg徱 ҳṛt, supporting its medicinal claims through bioactive mechanisms.
60) Shukradhatu (Sukradhatu, Shukra-dhatu):
'Śܰ-ٳ' refers to reproductive tissue in Ayurveda, symbolizing vitality and health. Its significance in the article suggests the holistic view of health and the interconnectedness of bodily systems, making it relevant in the context of ᾱṅg徱 ҳṛt.
61) Pittadosha (Pittadosa, Pitta-dosha):
'ʾٳٲ-ṣa' is one of the three doshas responsible for metabolism and energy. Its role in Ayurveda indicates how imbalances can lead to mental conditions, emphasizing the need for balanced formulations like ᾱṅg徱 ҳṛt to address these issues.
62) Green gram:
'Green gram' refers to a pulse often included in Ayurvedic diets due to its nutritional benefits. Its mention reflects the holistic approach in Ayurveda toward diet, emphasizing the importance of nutrition alongside herbal remedies in maintaining mental health.
63) Discussion:
'Discussion' signifies the analytical examination of results in the study. It provides insights into the implications of using ᾱṅg徱 ҳṛt as an alternative to conventional medications, enhancing understanding of its potential applications in mental health treatments.
64) Accumulation (Accumulating, Accumulate):
'Accumulate' refers to the buildup of substances in the body, such as neurotransmitters. In the context of ᾱṅg徱 ҳṛt, it signifies the intended pharmacological effects of allowing neurotransmitter availability to counter mood disorders.
65) Similarity:
'Similarity' denotes the concept of comparative aspects between two entities. In the article, it may refer to the related properties of ᾱṅg徱 ҳṛt and conventional antidepressants, underlining the significance of traditional remedies in addressing psychological issues.
66) Vatadosha (Vatadosa, Vata-dosha):
'ٲ-doṣa' underscores the influence of the ٲ dosha on bodily functions. Understanding and balancing ٲ is crucial in Ayurvedic practices, especially concerning mental health disorders like depression, directly linking to the formulation in the study.
67) Katurasa (Katu-rasa):
'ṭu-', translates to pungent taste, and indicates the flavor profile of certain herbs. Its role in Ayurvedic medicine suggests the therapeutic relevance of taste in enhancing effectiveness of formulations like ᾱṅg徱 ҳṛt in treating depression.
68) Yogavahin (Yogavahi, Yoga-vahi, Yoga-vahin):
'۴Dz' refers to substances that enhance the properties of other ingredients. In studying ᾱṅg徱 ҳṛt, it underscores the importance of ghee as a carrier, facilitating the absorption of active herbal compounds for their therapeutic effects.
69) Jealousy:
'Jealousy' refers to an emotional state involving insecurity and fear. Its mention may illustrate the broader psychological context within which ᾱṅg徱 ҳṛt operates, addressing mental health issues as part of the formulation's utility in Ayurvedic treatments.
70) Gaurava:
'Gaurava' relates to the feeling of heaviness, often associated with physical and mental wellness in Ayurveda. Its reference indicates its relevance in understanding imbalances that can lead to conditions treated by formulations like ᾱṅg徱 ҳṛt.
71) Tridosha (Tridosa, Tri-dosha):
'հṣa' encompasses the three doshas (ٲ, Pitta, Kapha) that influence health. Understanding their balance is crucial in Ayurveda for addressing psychological and physiological health, correlating directly with treatment strategies utilizing ᾱṅg徱 ҳṛt.
72) Samanya:
'峾Բⲹ' signifies similarity or commonality, especially in the context of herbal properties. Its importance highlights the shared characteristics of various ingredients leading to effective treatment outcomes, reinforcing the holistic perspective of formulations like ᾱṅg徱 ҳṛt.
73) Trikatu (Tri-katu):
'հ첹ṭu' refers to a combination of three pungent spices (usually black pepper, long pepper, and ginger). Its inclusion indicates the use of potent flavors in formulations like ᾱṅg徱 ҳṛt to enhance digestion and bioavailability of medicinal properties.
74) Snigdha:
'Snigdha' refers to unctuousness in Ayurveda, indicating nourishing qualities of substances. Its significance emphasizes the role of ghee in ᾱṅg徱 ҳṛt in promoting health through lubrication and nourishment of bodily tissues, enhancing emotional and physical well-being.
75) Goghrita (Goghrta, Go-ghrita):
'ҴDzṛt' refers specifically to cow ghee, a critical ingredient in Ayurveda. Its nurturing properties and ability to carry other medicinal substances make it essential in formulations like ᾱṅg徱 ҳṛt, enhancing the overall therapeutic effect.
[Note: The above list is limited to 75. Total glossary definitions available: 107]
Other Science Concepts:
Discover the significance of concepts within the article: �Evaluation of Hingvadi Ghrta in Behavioral Despair with Animals�. Further sources in the context of Science might help you critically compare this page with similair documents:
Ayurveda, Ghi, Adverse effect, Statistical analysis, Research Assistant, Animal model, Tail suspension test, Forced Swim Test, Imipramine hydrochloride, Antidepressant medication, Mood Disorder, Open access article, Comparative preclinical study.