Toll-like receptor 9 in chronic periodontitis and hyperlipidemia.
Journal name: Journal of Indian Society of Periodontology
Original article title: Estimation of Toll-like receptor 9 in gingival tissues of patients with chronic periodontitis with or without hyperlipidemia and its association with the presence of Porphyromonas gingivalis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Ipshita Narayan, Triveni Mavinakote Gowda, Dhoom Singh Mehta, Baron Tarun Kumar
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Estimation of Toll-like receptor 9 in gingival tissues of patients with chronic periodontitis with or without hyperlipidemia and its association with the presence of Porphyromonas gingivalis
Year: 2018 | Doi: 10.4103/jisp.jisp_124
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontitis is an inflammatory disease that affects the periodontium, primarily driven by bacterial insults, most commonly from Porphyromonas gingivalis. The immune response against such bacteria involves pattern recognition receptors, particularly Toll-like receptors (TLRs), which play a crucial role in mediating inflammation and tissue destruction. Among the TLRs, Toll-like receptor 9 (TLR9) is known to recognize unmethylated DNA patterns typical of bacteria, leading to the production of inflammatory cytokines. Recent studies suggest that TLR9 may be significantly upregulated in chronic periodontitis, highlighting its potential involvement in both periodontal disease and associated systemic conditions like hyperlipidemia.
The Role of TLR9 in Periodontal Disease
The study presented evaluates TLR9 expression in gingival tissue samples from patients with different periodontal health statuses: periodontally healthy patients, chronic periodontitis patients without hyperlipidemia, and those with chronic periodontitis alongside hyperlipidemia. Results demonstrated that TLR9 expression was significantly higher in the gingival connective tissues of the periodontitis groups compared to healthy controls. Additionally, there was a notable association between TLR9 levels and the presence of P. gingivalis, supporting the idea that this receptor facilitates the immune response in periodontal disease. Notably, TLR9 levels remained relatively consistent in the epithelium across all groups, suggesting that its heightened expression in connective tissue may be more indicative of periodontal disease than an adaptive response to hyperlipidemia.
Conclusion
The findings suggest a strong correlation between increased TLR9 levels and the presence of P. gingivalis in chronic periodontitis, underscoring the receptor's role in promoting inflammatory responses in periodontal tissue destruction. However, there appears to be a weak association between TLR9 levels and hyperlipidemia, indicating that while TLR9 may play a significant role in periodontal disease pathology, its influence on lipid metabolism is limited. Further research with larger cohorts is necessary to deepen the understanding of TLR9's role in periodontal health and disease, as well as its relationship with P. gingivalis.
FAQ section (important questions/answers):
What is the aim of the study on TLR9 and periodontal disease?
The study aims to evaluate the expression of Toll-like receptor 9 (TLR9) in periodontal disease, especially focusing on the association with hyperlipidemia and the presence of Porphyromonas gingivalis.
How were participants selected for this periodontal study?
Thirty participants aged 25-50 were randomly recruited and divided into three groups: healthy individuals, chronic periodontitis without hyperlipidemia, and chronic periodontitis with hyperlipidemia.
What were the main findings related to TLR9 expression?
The study found that TLR9-positive cell ratios in chronic periodontitis groups were significantly higher than healthy controls. However, TLR9 expression did not significantly differ between chronic periodontitis with and without hyperlipidemia.
What relationship was discovered between TLR9 and Porphyromonas gingivalis?
A positive association was found between TLR9 expression in gingival connective tissue and the presence of Porphyromonas gingivalis, suggesting its role in inflammatory responses in chronic periodontitis.
What limitations did the study acknowledge?
The study acknowledged limitations such as a small sample size and the need for larger, longitudinal studies to affirm the findings and better understand the relationship between TLR9 and periodontal health.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Toll-like receptor 9 in chronic periodontitis and hyperlipidemia.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to a structured arrangement of data, typically organized in rows and columns. In the context of this article, tables summarize key findings, statistical comparisons, and results from various experiments on periodontal disease, TLR9 expression, and the presence of Porphyromonas gingivalis, allowing for clear visual interpretation of data.
2) Study (Studying):
Study denotes a systematic investigation aimed at gaining knowledge or understanding of a phenomenon. This article highlights a specific study where researchers examined the expression of Toll-like receptor 9 in relation to chronic periodontitis and hyperlipidemia, contributing to the understanding of inflammatory processes in periodontal disease.
3) Disease:
Disease is a pathological condition characterized by an abnormal response or change in bodily function. The article particularly focuses on chronic periodontitis, an inflammatory disease affecting the periodontium, highlighting its association with bacterial infections and immune responses involving TLR9, particularly in the context of hyperlipidemia.
4) Inflammation:
Inflammation is the body’s response to injury or infection, manifesting as redness, heat, swelling, and pain. This study emphasizes the role of inflammation in chronic periodontitis, proposing that TLR9 mediates inflammatory responses to bacterial DNA, influencing tissue destruction in periodontal disease and other related conditions.
5) Bleeding:
Bleeding refers to the loss of blood, often a clinical sign of injury or disease. In periodontal studies, bleeding on probing is used as a diagnostic criterion for assessing the severity of gum disease. The presence of bleeding is crucial in evaluating the inflammatory state of periodontal tissues in this research.
6) Relative:
Relative indicates a comparative relationship between two or more variables. In the context of this study, relative differences in TLR9 expression were measured between healthy controls and patients with chronic periodontitis to determine the significance of bacterial interactions and their influence on inflammatory responses in periodontal disease.
7) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation of joints. The article mentions this condition to illustrate that inflammatory processes mediated by immune pathways, including TLRs, are not limited to periodontal disease but may also contribute to systemic diseases, highlighting the importance of understanding shared inflammatory mechanisms.
8) Measurement:
Measurement refers to the process of quantifying physical or biological parameters. In this study, measurements of TLR9 levels, clinical attachment levels, and probing depths were performed to assess the severity of periodontitis and correlate these findings with various patient groups, enhancing the understanding of periodontal pathology.
9) Discussion:
Discussion refers to the section of the article where the authors interpret their findings, relate them to existing research, and explore implications. In this study, the discussion elaborates on the role of TLR9 in periodontal disease, the relationship with hyperlipidemia, and how these insights contribute to the broader understanding of inflammation.
10) Antibiotic (Antibacterial):
Antibiotic refers to a type of medication used to treat bacterial infections. The study excludes participants with a history of antibiotic therapy, recognizing that such treatment can alter microbial composition and inflammatory responses, thus affecting the study's outcomes and the underlying pathology of chronic periodontitis.
11) Activity:
Activity denotes the performance of a function or task. In this study, the activity of TLR9 is assessed in relation to its role in immune responses and inflammation within periodontal tissue, providing insight into how bacterial DNA can influence inflammatory pathways and contribute to periodontal disease progression.
12) Surface:
Surface refers to the outermost layer of an object or organism. In periodontal disease, the gingival surface is significant as it interacts with oral bacteria. The study explores how bacteria, including Porphyromonas gingivalis, engage with toll-like receptors present on these surfaces, contributing to immune responses and inflammation.
13) Mandal:
Mandal is a proper noun, referring to a person or specific entity, in this case, likely part of the authorship or research team. The connection to the research emphasizes collaboration and recognition of contributions in scientific investigation, reinforcing the collaborative nature of scholarly research in health sciences.
14) Water:
Water is a vital component for all life forms and plays a crucial role in various biological functions. In the context of this study, water may not be explicitly mentioned, but the overall study may refer to biochemical processes or sample handling where water as a solvent is implicitly essential, especially in sample preparation.
15) Field:
Field refers to a specific area of study or expertise. The term may relate to the scientific field of periodontal research, highlighting the focus on understanding the interactions between bacteria, immune responses, and clinical parameters in periodontal disease. This research contributes to the broader field of dental and oral health science.
16) Sign:
Sign indicates a symptom or indication of a condition. In the study, signs such as TLR9 expression levels, inflammation indicators, and clinical features like bleeding on probing serve as crucial markers for assessing periodontal disease severity and immune reactions in patients, guiding diagnosis and treatment.
17) Line:
Line can refer to a boundary or a conceptual representation in research. In this context, it may signify the demarcation between health and disease in periodontal studies, helping researchers to delineate between the presence of TLR9 and signs of inflammation indicative of chronic periodontitis, affecting treatment outcomes.
18) Male:
Male pertains to the gender classification of individuals. In this study, the gender distribution among participants is noted, as demographics could influence the prevalence and severity of periodontal disease. Understanding the impact of gender on immune responses and disease progression is important for personalized medical approaches.
Other Science Concepts:
Discover the significance of concepts within the article: �Toll-like receptor 9 in chronic periodontitis and hyperlipidemia.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Sample size, Hyperlipidemia, Polymerase chain reaction, Lipid metabolism, Porphyromonas gingivalis, Intergroup comparison, Chronic periodontitis, Cross-sectional study design, Innate immune response, Pathogen-associated molecular patterns, Signal transduction pathway, Immunohistochemistry, Clinical attachment loss, Toll-like receptor 9.