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Effects of nonsurgical periodontal treatment on nitric oxide levels

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Journal name: Journal of Indian Society of Periodontology
Original article title: Influence of interventional nonsurgical periodontal treatment on levels of salivary and serum nitric oxide in smokers and nonsmokers with chronic periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Pooja Purushottam Wattamwar, Rajashri Abhay Kolte, Abhay Pandurang Kolte, Kanan Ketan Shah


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Influence of interventional nonsurgical periodontal treatment on levels of salivary and serum nitric oxide in smokers and nonsmokers with chronic periodontitis

Year: 2016 | Doi: 10.4103/jisp.jisp_106

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study investigates the impact of nonsurgical periodontal treatment on the levels of nitric oxide (NO) in smokers and nonsmokers suffering from chronic periodontitis. NO is recognized for its significant role as a signaling molecule in various biological processes but can also contribute to tissue destruction when present in excessive amounts. Smoking has been shown to alter the inflammatory response, compounding the challenges of managing periodontal disease. The research aimed to evaluate serum and saliva NO levels before and after periodontal treatment in both smoker and nonsmoker groups and to understand how smoking affects clinical outcomes in chronic periodontitis patients.

Influence of Smoking on Nitric Oxide Levels

The results revealed that smokers exhibited significantly higher serum and saliva NO levels than nonsmokers at baseline. Specifically, smokers had serum NO levels of 30.3 μM and saliva NO levels of 50.4 μM compared to nonsmokers, who had levels of 20.05 μM and 37.5 μM, respectively. After nonsurgical periodontal therapy, both groups showed a reduction in NO levels; however, the decrease was more pronounced in nonsmokers. This indicates that smoking not only heightens the inflammatory response in periodontal disease but also diminishes the effectiveness of treatment, as evidenced by the relatively smaller reductions in NO levels among smokers post-therapy. The study highlights the relationship between NO concentrations and the more destructive manifestations of periodontal disease in smokers.

Conclusion

In conclusion, the findings suggest that serum and salivary NO levels can serve as effective biomarkers for assessing the inflammatory state of the periodontium, particularly in the context of smoking-related periodontal disease. Although both smokers and nonsmokers benefited from nonsurgical treatment, the greater improvement observed in nonsmokers points to the negative impact of smoking on periodontal healing. More extensive and longitudinal studies are needed to further elucidate the effects of nonsurgical periodontal treatment on NO levels and to establish NO as a novel biomarker for periodontal disease.

FAQ section (important questions/answers):

What was the objective of the study on nitric oxide?

The study aimed to assess the effect of nonsurgical periodontal treatment on salivary and serum nitric oxide levels in smokers and nonsmokers with chronic periodontitis.

How did smoking affect nitric oxide levels in the study?

Smokers exhibited higher serum and saliva nitric oxide levels than nonsmokers at baseline, suggesting increased oxidative stress and inflammatory responses associated with smoking.

What were the main findings after Phase I therapy?

Both groups showed significant improvement in clinical parameters and reduced nitric oxide levels, but the reduction was more pronounced in nonsmokers compared to smokers.

What conclusions were drawn regarding nitric oxide as a biomarker?

Serum and salivary nitric oxide levels can indicate inflammatory conditions in periodontal disease. Higher levels in smokers suggest more destructive expression of chronic periodontitis.

What future research directions were suggested in the study?

Further longitudinal studies are needed to clarify nitric oxide's role in periodontal disease pathogenesis and validate it as a novel biomarker.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effects of nonsurgical periodontal treatment on nitric oxide levels�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
Tables are crucial in research papers as they organize data in a clear, concise format. They allow for easy comparison and analysis of study results, showing clinical parameters, statistical significance, and variable relationships. In this study, tables present findings on nitric oxide levels and clinical parameters during nonsurgical periodontal therapy efficiently.

2) Study (Studying):
A study refers to a systematic investigation aimed at discovering new information or validating existing knowledge. Here, the study focuses on the effects of nonsurgical periodontal treatment on nitric oxide levels in chronic periodontitis patients, highlighting differences between smokers and non-smokers, which enriches clinical understanding and treatment protocols.

3) Disease:
Disease represents a pathological condition that disrupts normal bodily functions. In this context, periodontal disease involves inflammation and destruction of supporting dental structures. Understanding its mechanisms, such as the role of nitric oxide, is vital for effective treatment strategies and reducing disease progression, particularly in smokers who are more susceptible.

4) Blood:
Blood is essential for systemic health, transporting nutrients, gases, and waste. In this research, blood samples are analyzed for nitric oxide levels, providing insights into systemic inflammation and disease status. Blood as a medium highlights the connection between periodontal conditions and overall health, emphasizing the need for comprehensive patient assessments.

5) Inflammation:
Inflammation is a biological response to harmful stimuli, including pathogens and injury. In periodontal disease, inflammatory processes contribute significantly to tissue destruction. The study investigates how nonsurgical treatments affect inflammatory markers like nitric oxide, helping to clarify the underlying mechanisms of periodontitis and assess the efficacy of therapeutic interventions.

6) Species:
In biological contexts, species refer to distinct groups of organisms with common characteristics. Here, 'species' indirectly relates to host-bacterial interactions within the study of periodontal disease. The research emphasizes the role of specific bacterial species in periodontal tissue inflammation and destruction, which is vital for developing targeted treatment options.

7) Reason:
Reason denotes the underlying justification for research pursuits and clinical practices. In this study, the reason for analyzing nitric oxide levels and treatment effects is to better understand the inflammatory processes in periodontal disease, especially in smokers. This reasoning is essential for enhancing therapeutic strategies and patient outcomes.

8) Male:
Male refers to the sex of individuals. In the study, the sample primarily consists of male participants due to cultural considerations and smoking patterns. This demographic focus may influence study findings, highlighting the need for inclusive research that addresses gender-related differences in periodontal disease severity and treatment response.

9) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic autoimmune disease that can complicate treatment outcomes in periodontal disease due to shared inflammatory mechanisms. The study excludes patients with systemic diseases like rheumatoid arthritis to isolate the impact of periodontal therapy, thereby clarifying the effects of smoking and inflammation on periodontal health.

10) Antibiotic (Antibacterial):
Antibiotics are medications employed to treat bacterial infections. Although not the primary focus of this study, antibiotics are relevant in managing periodontal disease. Understanding how smoking can affect antibiotic effectiveness may guide dental clinicians in prescribing appropriate treatments and enhancing outcomes for patients facing chronic periodontitis.

11) Surrounding:
Surrounding contexts refer to the biological environment influencing disease outcomes. In periodontal disease, surrounding tissues' health can affect inflammation and healing processes. This study considers how smoking alters the surrounding microenvironment of periodontal tissues, emphasizing a need for holistic treatment approaches that account for these interrelations.

12) Measurement:
Measurement pertains to the systematic quantification of variables in research. The study utilizes precise measurements of nitric oxide levels to assess inflammation and treatment efficacy. Accurate measurement is crucial to validate findings and support clinical decisions based on empirical data, ensuring the reliability of the conclusions drawn from the research.

13) Observation:
Observation refers to collecting data through careful examination. In this study, clinical observations of periodontal parameters before and after treatment form the basis for evaluating the effects of nonsurgical therapies. Observational data is critical for understanding treatment efficacy and patient responses within clinical settings, guiding future practice.

14) Discussion:
Discussion sections in research papers synthesize findings, implications, and future directions. In this study, the discussion elaborates on how smoking influences nitric oxide levels and periodontal disease severity, contextualizing results within existing literature and posing important clinical questions, contributing to the overall understanding of periodontal health management.

15) Collecting:
Collecting involves gathering data or samples for analysis. In the study, collecting serum and saliva samples is essential for assessing nitric oxide levels, providing insights into periodontal inflammation. The methodology of collecting samples significantly impacts data quality and study outcomes, underpinning the research's validity and reliability.

16) Pregnant:
Pregnant refers to women carrying developing offspring. Pregnancy can complicate periodontal disease conditions and influences treatment choices. The study excludes pregnant women to control variables and ensure safe treatment protocols, highlighting the importance of considering reproductive health in periodontal research and patient care.

17) Hygiene (Hygienic):
Hygiene encompasses practices that maintain health and prevent disease. In periodontal care, proper oral hygiene is crucial for managing periodontitis. The study emphasizes the role of hygiene education as part of therapy, showing how improving patient hygiene habits can complement clinical treatments and reduce disease severity in both smokers and nonsmokers.

18) Nature:
Nature relates to inherent qualities and biological processes affecting health. The nature of periodontal disease and its inflammatory responses delineate the pathogenesis observed in patients. This study investigates the natural interactions between smoking and NO levels, contributing to understanding periodontal diseases and tailoring treatments based on biological behaviors.

19) Nagapura (Naga-pura):
Nagpur is the geographical location where the study was conducted. This regional context provides insights into demographic and lifestyle factors that may influence the prevalence and severity of periodontal disease in the population. Understanding local health trends enriches the applicability of research findings to specific communities and populations.

20) Visit:
Visit refers to the clinical consultations for patient assessment and treatment. In this context, the study records patient visits at baseline and after nonsurgical therapy. These visits are instrumental in evaluating treatment outcomes, providing a timeline for assessing changes in clinical parameters and nitric oxide levels correlated with therapy effectiveness.

Other Science Concepts:

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Discover the significance of concepts within the article: �Effects of nonsurgical periodontal treatment on nitric oxide levels�. Further sources in the context of Science might help you critically compare this page with similair documents:

Longitudinal studies, Pilot study, Reactive oxygen species, Plaque index, Gingival index, Institutional ethics committee, Nitric oxide, Chronic periodontitis, Clinical attachment level, Biochemical marker, Smokers and nonsmokers, Oral hygiene instruction, Smoking, Clinical parameter, Systemic inflammatory response, Serum NO levels.

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