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Efficacy of Ayurvedic protocol in major depressive disorder: RCT

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Efficacy of whole system ayurveda management protocol in major depressive disorder- A randomized controlled clinical trial
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Anjali Punia, Sameeran Chate, Basavaraj R. Tubaki, Nagula Himaja


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Efficacy of whole system ayurveda management protocol in major depressive disorder- A randomized controlled clinical trial

Year: 2024 | Doi: 10.1016/j.jaim.2024.100896

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of Ayurvedic protocol in major depressive disorder: RCT�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Depression:
Depression refers to a mood disorder characterized by persistent feelings of sadness, loss of interest, and a range of emotional and physical problems. It significantly affects daily functions and quality of life. Understanding its complexities is crucial for developing effective treatments, as highlighted by various studies mentioned.

2) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine that emphasizes a holistic approach to health and wellness, integrating body, mind, and spirit. It utilizes natural remedies, dietary guidelines, and lifestyle modifications to restore balance. The study explores Ayurveda's potential effectiveness in managing Major Depressive Disorder (MDD).

3) Study (Studying):
The study mentioned aims to evaluate the efficacy of a Whole System Ayurveda Management Protocol on Major Depressive Disorder. Research methodologies are crucial for establishing scientifically validated treatment options, contributing significantly to the growing body of literature on complementary and alternative therapies.

4) Anxiety:
Anxiety is characterized by excessive worry, fear, and apprehension. It is often comorbid with depression, complicating treatment approaches. The study leverages standardized scales like the Hamilton Anxiety Rating Scale (HARS) to assess anxiety levels in patients, indicating its importance in holistic mental health evaluations.

5) Table:
Tables in research studies help synthesize and present data systematically. In this context, tables summarize baseline characteristics, treatment effects, and clinical outcomes, allowing for easier comparison and analysis of results across the control and Ayurveda groups, thus enhancing transparency and reproducibility of the findings.

6) Drug:
Drugs refer to substances used to diagnose, treat, or prevent diseases. In this study, the focus is on Escitalopram, a common antidepressant used as a control, and Ayurvedic formulations. Understanding their roles and effects is critical for assessing the safety and efficacy of treatment protocols.

7) Quality:
Quality, particularly in a medical context, relates to the effectiveness and acceptability of treatments and interventions. The study emphasizes quality of life improvements in patients receiving Ayurveda, measuring such changes against recognized standards like the WHO Quality of Life-BREF scale.

8) Life:
Life quality and overall well-being are central themes in mental health research. The study investigates how the Whole System Ayurveda Management Protocol impacts various life domains, aiming to enhance not just symptom relief but also overall social functioning and emotional health in individuals with MDD.

9) Srotas (Shrotas):
In Ayurveda, 'Srotas' refers to the channels or systems within the body that facilitate the flow of substances, including vital energies and nutrients. Understanding the role of Srotas is essential for diagnosing and treating conditions like depression from an Ayurvedic perspective, guiding a holistic treatment plan.

10) Yoga:
Yoga is a physical, mental, and spiritual practice that promotes well-being and is often integrated into Ayurveda. It is believed to help alleviate symptoms of depression and anxiety by enhancing physical fitness, reducing stress, and fostering mindfulness, contributing to improved mental health outcomes.

11) Activity:
Activity, particularly physical activity, is linked to improved mental health outcomes. The study recognizes the role of exercise and yoga as part of the Ayurvedic management protocol, emphasizing the importance of active lifestyle choices in combating depression and enhancing overall quality of life.

12) Music:
Music is utilized in therapeutic contexts for its psychological benefits, including mood enhancement and stress reduction. In the study, music therapy is incorporated as part of the Whole System Ayurveda Management Protocol, reflecting its potential as a complementary treatment for depression.

13) Medicine:
Medicine, as a broad term, encompasses various methodologies, practices, and substances aimed at treating illnesses. The relevance here includes exploring both pharmaceutical and Ayurvedic medicinal approaches to treating Major Depressive Disorder, comparing their effectiveness and safety.

14) Dosha (Dosa):
Dosha represents the three fundamental energies in Ayurvedic medicine: Vata, Pitta, and Kapha. Each dosha governs various physiological and psychological aspects of an individual's health. The study assesses the relevance of doshas in diagnosing and managing conditions like depression within the Ayurvedic framework.

15) Vati:
Vati refers to a form of Ayurvedic medicinal preparation that is often in tablet form. This term is relevant in the context of the study, where various Ayurvedic vati, such as Brahmi vati, are employed to treat Major Depressive Disorder, reflecting traditional practices in managing mental health.

16) Disease:
Disease denotes any abnormal condition affecting an organism. In this study, the focus is on Major Depressive Disorder, a significant public health concern. Understanding the disease mechanism and effective treatment options is integral for improving patient outcomes and mental health care.

17) Mantra (Mamtra):
Mantras are sacred sounds or phrases in Hinduism and Buddhism used during meditation or prayers. Their use in the Ayurvedic context aims to promote mental well-being, reduce stress, and facilitate a positive mindset, contributing to holistic health approaches in managing depression.

18) Kaphaja:
Kaphaja refers to a particular type of dosha related to the elements of water and earth in Ayurvedic medicine. It is associated with qualities like stability and solidity. Understanding Kaphaja's influence on emotional health can help tailor specific treatments for conditions like depression.

19) Writing:
Writing serves as a therapeutic outlet for expressing thoughts, emotions, and experiences related to mental health. In clinical research, documentation is vital for recording data, treatment effects, and patient progress, aiding in transparency and reproducibility.

20) Brahmi:
Brahmi, also known as Bacopa monnieri, is an Ayurvedic herb recognized for its cognitive-enhancing properties. It is used in the study as part of the Ayurvedic treatment for depression, emphasizing its potential benefits for improving mental clarity and emotional stability.

21) Vata:
Vata is one of the three doshas in Ayurveda, associated with air and space elements. It governs various physiological functions and has implications for mental health. Understanding Vata is crucial for addressing conditions like anxiety and depression in Ayurvedic practices.

22) Rasayana (Rasa-ayana):
Rasayana refers to the Ayurvedic practice focused on rejuvenation and longevity. It encompasses dietary and lifestyle practices aimed at promoting overall health. The study examines how Rasayana influences the management of Major Depressive Disorder, illustrating its holistic approach to well-being.

23) Kapha:
Kapha is another dosha in Ayurveda, characterized by qualities of water and earth, representing structure and stability. Its balance is essential for physical and emotional health. In this study, understanding Kapha's role aids in developing effective personalized treatment plans for depression.

24) Post:
In this context, 'Post' pertains to post-treatment evaluations or data collection phases in the study. Understanding changes in patients' conditions after interventions is crucial for assessing the long-term efficacy of the Whole System Ayurveda Management Protocol compared to standard drugs.

25) Mud:
Mood reflects an individual's emotional state, profoundly impacting mental health. The study investigates how interventions like Ayurveda and its components affect mood stability, exploring the relationship between mood changes and the overall management of Major Depressive Disorder.

26) Unmada:
Unmada is a term in Ayurveda denoting a state of madness or severe mental disturbance. Understanding Unmada is important in the context of depressive disorders as it guides clinical interventions, including holistic therapies that address severe emotional and psychological fluctuations.

27) Indian:
Indian refers to anything relating to India, including culture, traditions, and health practices like Ayurveda. This context is relevant in examining how indigenous systems of medicine contribute to the management of modern mental health issues like depression.

28) India:
India is a diverse country known for its rich cultural heritage, including traditional healthcare systems like Ayurveda. The study conducted in India highlights the relevance of indigenous approaches in addressing contemporary mental health challenges, particularly Major Depressive Disorder.

29) Ghana:
In this context, 'Ghana' is likely mentioned as an Ayurvedic preparation or as part of the terminology, possibly referring to powdered forms of herbal remedies used in the study to treat mental health disorders.

30) Line:
Line in this study may refer to a particular line of investigation or methodological approach taken to assess the effectiveness of interventions like Ayurveda. It emphasizes structured inquiry in clinical trials for establishing scientific validity.

31) Mental health:
Mental health encompasses emotional, psychological, and social well-being, affecting how individuals think, feel, and act. The study aims to address mental health issues like Major Depressive Disorder through integrative approaches, including Ayurveda, reinforcing the importance of holistic care.

32) Inflammation:
Inflammation is a biological response that can contribute to various mental health disorders, including depression. Understanding its role in the study helps to explore how Ayurvedic interventions may mitigate inflammatory processes and improve mental health outcomes.

33) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Ashwagandha is a highly regarded herb in Ayurveda, known for its adaptogenic properties. It's often used to enhance physical and mental vitality. The study includes Ashwagandha as part of the intervention for depression, highlighting its potential benefits for emotional balance.

34) Visada (Vishada, Visha-da):
Vishada refers to a state of despondency or mental distress in Ayurveda. Recognizing this condition helps practitioners frame therapeutic interventions, demonstrating the necessity of addressing specific emotional and psychological states in managing depressive disorders.

35) Channel:
Channel, in this context, may refer to the Srotas, or pathways in Ayurveda through which vital energies and nutrients travel. Understanding these channels is essential for diagnosing and treating mental health conditions effectively.

36) Science (Scientific):
Science emphasizes evidence-based approaches to understanding health conditions. The study aims to marry traditional practices like Ayurveda with modern scientific methodologies, validating their effectiveness for treating disorders such as depression through rigorous research.

37) Vataka:
Vataka signifies a specific dosage form in Ayurveda often used as a reference for various herbal or mineral formulations. Its relevance in the study indicates the application of traditional formulations in contemporary clinical research for mental health issues.

38) Pitta:
Pitta is a dosha characterized by qualities of fire and water, governing metabolism, and transformation. Its balance is vital for emotional and physical well-being. Assessing Pitta allows for targeted Ayurvedic treatments to manage Major Depressive Disorder effectively.

39) Rules:
Rules may refer to principles or guidelines that govern the practice of Ayurvedic medicine. Adherence to these rules is essential for ensuring effective treatments and outcomes in managing conditions like depression within the traditional framework.

40) Withania somnifera:
Withania somnifera, or Ashwagandha, is a key herb utilized in Ayurvedic medicine. Its adaptogenic qualities make it significant in treating stress and anxiety, underscoring its role in protocols designed for managing depressive disorders as noted in the study.

41) Meditation:
Meditation is a practice that involves concentrating the mind to achieve a state of mental clarity and emotional stability. Integrating meditation within Ayurveda may enhance mental health treatments by promoting relaxation and reducing symptoms associated with depression and anxiety.

42) Listening:
Listening refers to the therapeutic process of engaging with music or sounds for mental relaxation and healing. In therapy, listening to music has been shown to reduce depressive symptoms, making it a relevant component in the Ayurvedic treatment approaches of the study.

43) Family:
Family plays a vital role in mental health support systems. The dynamics of familial relationships can influence emotional well-being, and involving family members in treatment plans can enhance the success of interventions aimed at addressing depression.

44) Medium:
Medium may refer to the methods or modalities used for treatment. The study explores various mediums, such as Ayurvedic practices that incorporate music, yoga, and mindfulness techniques, illustrating a comprehensive approach to mental health management.

45) Acara:
Achara refers to behavioral practices in Ayurveda that encompass moral and ethical conduct. Understanding Achara is essential for guiding patients toward healthier lifestyles, which can play a crucial role in mental health and the management of depression.

46) Agni:
Agni, or digestive fire, is a core concept in Ayurveda that denotes metabolic processes. Its balance is crucial for overall health. In the context of managing depression, ensuring proper Agni could enhance treatments by promoting physical and mental well-being.

47) Tama:
Tama is associated with darkness or lethargy as a dosha quality in Ayurveda. Understanding its implications is critical for managing mental health as it often relates to depressive states. Therapeutic interventions may aim to balance Tama to improve emotional stability.

48) Diet:
Diet significantly impacts mental health, influencing mood and emotional well-being. The study highlights dietary practices rooted in Ayurveda, suggesting that nutrition tailored to individual doshic imbalances can enhance treatment outcomes for depression and anxiety.

49) Gold (Golden):
Gold may refer to a metaphor for value or excellence in treatment approaches. It highlights the study's objective to establish the effectiveness of Ayurveda compared to conventional treatments like Escitalopram, aiming for 'gold-standard' outcomes in managing depression.

50) Pur:
Poor conditions may refer to aspects like poor diet, lifestyle factors, and inadequate mental health care contributing to increased depression rates. Addressing these poor conditions is crucial for developing comprehensive treatments that consider socio-economic disparities in mental health.

51) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as licorice, is used in traditional medicine for various therapeutic effects. Its inclusion in Ayurvedic protocols signifies its potential benefits in alleviating symptoms of depression, highlighting the importance of incorporating diverse herbal remedies in treatment plans.

52) Crocus sativus:
Crocus sativus, or saffron, is renowned for its medicinal properties, including anti-depressant effects. It may enhance mood and alleviate depressive symptoms, warranting its exploration in the study to shed light on natural treatments for mental health disorders.

53) Vatapitta (Vata-pitta):
Vata-pitta refers to a combined dosha diagnosis in Ayurveda, illustrating the complexity of individual constitutions in health. Understanding this interaction is important for tailoring treatment protocols, providing a comprehensive approach to managing mental health conditions like depression.

54) Substance:
Substance refers to tangible or chemical forms used in treatments. In this study, the substances utilized include Ayurvedic herbs and standard medications, highlighting the importance of both conventional and alternative approaches in care for mental health disorders.

55) Education:
Education pertains to the knowledge base and learning around mental health treatments. In this context, education can empower practitioners and patients alike with information on effective interventions for depression, fostering a more informed approach to managing mental well-being.

56) Agnivesha (Agnivesa, Agni-vesha):
Agnivesa is a notable figure in the history of Ayurveda, known for his contributions to classical texts. Understanding his work provides context for traditional practices and philosophies in Ayurvedic medicine, highlighting its longstanding relevance in treating various health conditions.

57) Samhita:
Samhita refers to collections of Ayurvedic texts that compile knowledge about healing practices. These texts form the foundation for contemporary Ayurvedic therapies, emphasizing the importance of historical knowledge in understanding and treating mental health issues like depression today.

58) Vishama (Visama):
Vishama refers to an imbalanced or irregular state in Ayurveda. It highlights the significance of addressing imbalances in physical and mental health, reinforcing the study's focus on treating Major Depressive Disorder through comprehensive Ayurvedic interventions.

59) Chennai:
Chennai may be referenced as a location for the study, indicating regional aspects of mental health and Ayurvedic treatments. Understanding geographical influences is important for contextualizing health needs and tailoring treatment plans to specific populations.

60) Meeting:
Meeting refers to gatherings of individuals, particularly professionals in mental health or Ayurveda. Such interactions facilitate knowledge exchange, research collaboration, and shared insights, which are essential for advancing understanding and treatment of conditions like depression.

61) Prabha:
Prabha may refer to an author or contributor whose work is relevant in the study. Understanding individuals involved adds depth to the research context, highlighting the collaborative efforts in advancing treatment protocols for mental health conditions.

62) Mishra (Misra):
Mishra is likely referenced as a contributor or researcher in the field of Ayurveda. Acknowledging individuals' contributions enhances the study's credibility and provides insights into the rich collaborative nature of research in alternative medicine.

63) Sharman (Sarma, Sharma, Sarman):
Sharma may refer to another key figure in Ayurvedic research. Acknowledging various contributors emphasizes the collaborative nature of clinical studies, revealing the collective effort to integrate traditional knowledge with modern scientific inquiry.

64) Nature:
Nature refers to the inherent characteristics or qualities of individuals or treatments. In therapeutic contexts, recognizing a patient's nature is essential for personalized treatment strategies, as therapeutic approaches in Ayurveda are tailored to individual doshas and mental health needs.

65) Reason:
Reason pertains to the rationale behind therapeutic choices or research inquiries. The study's rationale is crucial for establishing the significance of alternative medicine approaches to mental health, particularly the effectiveness of Ayurveda in treating Major Depressive Disorder.

66) House:
House may reference a metaphorical or literal space where healing occurs. In Ayurveda, the environment plays a role in treatment efficacy. Understanding the spaces we inhabit can provide insights into emotional and mental well-being, linking home environment to psychological health.

67) Grief:
Grief represents a profound emotional response to loss, often associated with depression. An understanding of grief is essential for effective treatment, as it can inform therapeutic interventions in both Ayurveda and modern medicine, tailoring approaches to address emotional pain.

68) Blood:
Blood refers to bodily fluids that carry nutrients and oxygen. In Ayurvedic medicine, the quality and composition of blood are significant for understanding health conditions such as depression. Investigating blood-related factors may yield valuable insights into mental health treatments.

69) Worry (Worried, Worrying):
Worry indicates persistent anxiety or concern often associated with mental disorders like depression and anxiety. Addressing worry is essential in therapeutic disciplines, as alleviating excessive concern can significantly contribute to improving patients' overall mental health and quality of life.

70) Osha (Osa):
Osha may refer to natural or herbal elements used in Ayurvedic treatments. Its relevance emphasizes the importance of integrating various natural substances in managing mental health conditions, illustrating traditional approaches to healing.

71) Gama:
Gama may serve as a specific term in Ayurvedic practices or as a contextually relevant reference within the study. Its implications highlight the multifaceted nature of Ayurvedic medicine in addressing mental health problems like depression.

72) Sama (Shama):
Sama signifies balance or harmony, particularly concerning doshas in Ayurveda. Understanding Sama is crucial in the treatment of mental health disorders, as restoring balance is central to effective interventions for conditions like depression.

73) Sam (Sham):
Sham may refer to techniques or practices aimed at achieving calmness or tranquility. In Ayurveda and mental health contexts, Sham methodologies are essential for facilitating emotional well-being, making them relevant in treatment protocols for depressive disorders.

74) Rich (Rch):
Rich may metaphorically relate to abundance, often used in contexts highlighting wealth of resources or knowledge in Ayurvedic practices. This emphasizes the richness of traditional medicinal knowledge in addressing contemporary health issues.

75) Pir:
Peer refers to colleagues or professionals within a similar field. Collaboration and peer feedback are vital for research integrity and advancement, allowing for diverse perspectives in evaluating treatment efficacy and scientific rigor in studies.

[Note: The above list is limited to 75. Total glossary definitions available: 114]

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Discover the significance of concepts within the article: �Efficacy of Ayurvedic protocol in major depressive disorder: RCT�. Further sources in the context of Science might help you critically compare this page with similair documents:

Adverse effect, Informed consent, Randomized controlled trial, Hamilton Anxiety Rating Scale, Institutional ethics committee, Pittsburgh Sleep Quality Index, Hamilton Depression Rating Scale, Intervention duration, Major depressive disorder, Brief Psychiatric Rating Scale, Pilot testing, WHO quality of life BREF, Clinical assessment scale, Outcome Measures.

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