Lagenaria siceraria powder's effect on sodium oxalate urolithiasis in rats
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Rahul V. Takawale, Vishal R. Mali, Chinmay U. Kapase, Subhash L. Bodhankar
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats
Year: 2012 | Doi: 10.4103/0975-9476.96522
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Lagenaria siceraria powder's effect on sodium oxalate urolithiasis in rats�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
This word refers to the male Wistar rats used in the experiment. Animal models are crucial in biomedical research as they help researchers understand physiological and pathological processes, enabling the assessment of treatment efficacy, side effects, and mechanisms of action for substances being tested, such as Lagenaria siceraria fruit powder in this study.
2) India:
India is the geographical context of the study where Lagenaria siceraria (bottle gourd) is traditionally utilized in medicine. The cultural and historical background of indigenous treatments in India enriches the understanding of natural remedies and their potential applications in modern pharmacotherapy, particularly in the treatment of urolithiasis.
3) Drug:
Drug refers to the substances used for treatment in the experiment, namely Lagenaria siceraria fruit powder and Cystone. Evaluating these compounds contributes to the broader pharmacological understanding of herbal and synthetic remedies in managing health conditions, highlighting the ongoing search for effective therapeutic agents against kidney stones.
4) Table:
This word refers to the structured representation of data in the form of tables within the study. Tables facilitate the clear presentation of experimental results, allowing for easy visualization and comparison of various parameters like urine output, serum levels, and histopathological changes among different treatment groups.
5) Blood:
Blood is significant in the study as it is analyzed for serum parameters, including creatinine and uric acid levels. These measurements are critical for assessing kidney function and overall health of the rats, providing insights into the effectiveness of the treatments being tested against urolithiasis.
6) Pune:
Pune is the location where the study was conducted and where the institutions involved in the research are situated. Being a hub for scientific research, Pune’s resources and expertise contribute to the credibility and advancement of studies related to traditional medicine and pharmacology in India.
7) Powder:
Powder refers to the form in which Lagenaria siceraria is administered in this study. Powdered herbal formulations are common in herbal medicine as they allow for easier dosage and bioavailability. The powder’s preparation impacts its chemical stability, efficacy, and potential therapeutic benefits in treating conditions such as urolithiasis.
8) Swelling:
Swelling pertains to the observation of tubular cell swelling in kidney tissues identified in the histopathological examination. This response indicates renal impairment due to the effects of sodium oxalate. It highlights the physiological changes that can occur during urolithiasis and the importance of preventing such cellular damage.
9) Activity:
Activity in this context refers to the biological effects of LSFP against urolithiasis. Understanding the antiurolithic activity of herbal substances like Lagenaria siceraria is essential in validating their traditional uses and enhancing their acceptance in contemporary medicine as potential alternatives to conventional therapies.
10) Mineral:
Mineral refers to the essential nutrients found in the Lagenaria siceraria fruit. Minerals are vital for various bodily functions, including the maintenance of kidney health and prevention of stone formation. The mineral composition of foods can influence the risk of developing urinary stones and overall metabolic health.
11) Medium:
Medium in this context pertains to the moderate level of crystal deposition observed in the LSFP group during histopathological examinations. Understanding the degree of such deposition aids in evaluating the therapeutic effectiveness of LSFP in comparison to the control and standard treatment groups in mitigating urolithiasis.
12) Water:
Water is a fundamental component in biological systems and is crucial for urine formation. In the context of this study, hydration status might influence the formation of urinary stones. Effective management of urolithiasis often involves adequate fluid intake to dilute urinary constituents and reduce crystallization risk.
13) Study (Studying):
Study refers to the research conducted to evaluate the effects of Lagenaria siceraria on sodium oxalate-induced urolithiasis. Scientific studies are designed to generate evidence-based conclusions that can inform clinical practices, develop new therapies, and enhance understanding of disease mechanisms and treatment interventions.
14) Cage (CÄge):
Cage refers to the metabolic cages used for the individual housing of rats during urine collection. Such specialized cages facilitate accurate measurement of urine output and composition while minimizing stress on the animals, leading to more reliable and valid experimental results during pharmacological assessments.
15) Rubia cordifolia:
Rubia cordifolia is mentioned as a component in Cystone, which is the standard treatment group in the study. Knowledge of individual herbal constituents like Rubia cordifolia can guide research into their specific therapeutic actions in urolithiasis, contributing to the composite efficacy of herbal preparations.
16) Observation:
Observation in this context relates to the assessments made during the study, including changes in urine and serum parameters as well as histopathological evaluations. Systematic observations are foundational to scientific research, allowing for the identification of significant trends, correlations, and treatment outcomes.
17) Measurement:
Measurement pertains to the quantification of various parameters such as urinary oxalate, creatinine, and histopathological changes post-treatment. Accurate measurements are vital in validating experimental findings and drawing meaningful conclusions about the effectiveness and safety of therapeutic agents like LSFP against urolithiasis.
18) Developing:
Developing refers to the context of nations, like India, that continue to face challenges with urolithiasis. Understanding the health issues prevalent in developing regions is crucial for creating targeted interventions and public health strategies to address complications associated with kidney stones and their treatments.
19) Accumulation (Accumulating, Accumulate):
Accumulate refers to the buildup of waste products like creatinine and uric acid in the blood due to impaired renal function caused by urolithiasis. Studying the accumulation of these substances is essential for assessing kidney health and determining the effectiveness of treatments in restoring normal kidney function.
20) Science (Scientific):
Scientific indicates the approach taken in the study, emphasizing the evidence-based methodology and analysis employed. A scientific approach ensures that the findings are credible, reproducible, and can be used to inform medical practices, guiding the integration of traditional remedies into contemporary healthcare.
21) Composite:
Composite refers to the formulation of Cystone, which contains multiple herbal ingredients. Understanding the composite nature of herbal remedies helps in elucidating their synergistic effects, potential benefits, and mechanisms of action, ultimately leading to enhanced treatment options for conditions like urolithiasis.
22) Apamarga (ApÄmÄrga, ApamÄrga):
Apamarga is another herb included in the composition of Cystone. Knowledge of its specific contributions to the formulation provides insight into the collaborative effects of herbal ingredients. This understanding can aid in the development of targeted treatment strategies for managing conditions such as kidney stones.
23) Sahadevi (Saha-devi, Sahadevī):
Sahadevi is included in the Cystone formulation. Understanding its role and effects contributes to the overall efficacy of combined herbal products. Investigating the actions of individual herbs can offer a clearer picture of how they work together to provide therapeutic benefits in urolithiasis treatment.
24) Himalaya (HimÄlaya, Hima-alaya):
Himalaya refers to Himalaya Herbal Healthcare, the manufacturer of Cystone, the standard treatment referenced in the study. The brand's reputation in herbal medicine influences the public's trust in such products, enhancing the need for research to substantiate claims of efficacy and safety in their use.
25) Medicine:
Medicine refers to the broader field of healthcare that encompasses both conventional and traditional practices. The study of Lagenaria siceraria in the context of urolithiasis combines elements of both herbology and modern pharmacology, highlighting the importance of interdisciplinary approaches in advancing healthcare.
26) Relative:
Relative relates to the comparison of results between treatment groups. Assessing relative differences in urinary and serum parameters among different treatment conditions is fundamental in determining the significance of the findings and the effectiveness of LSFP against sodium oxalate-induced urolithiasis.
27) Marathi (MarÄá¹hÄ«, MarÄthi):
Marathi references the local language spoken in Maharashtra, India, where the study takes place. The cultural context informs various aspects of traditional medicine practices, providing a vital link between regional heritage and modern healthcare approaches, especially in the use of indigenous plants for health conditions.
28) Disease:
Disease relates to the medical condition of urolithiasis being studied. Understanding the mechanisms, causes, and treatments of diseases is fundamental in medical research. Identifying effective therapies for diseases like urolithiasis can greatly enhance the quality of life for affected individuals.
29) Bhasma (Bhasman):
Bhasma refers to the processed mineral ash used in traditional Indian medicine, sometimes included in herbal formulations like Cystone. The inclusion of such components emphasizes the blending of ancient practices with modern research, advocating for a deeper understanding of their roles in health and disease treatment.
30) Lauki:
Lauki is another name for Lagenaria siceraria in Hindi. The regional terminology underlines the significance of traditional knowledge in herbal medicine and promotes awareness of local medicinal plants, fostering appreciation for their potential therapeutic uses as alternative treatments within a contemporary clinical context.
31) Ayus (Ä€yus, Ayush):
Ayush refers to the traditional medicine system in India which includes Ayurveda, Yoga, Unani, Siddha, and Homeopathy. The recognition of these systems in research supports the integration of traditional knowledge with scientific validation, providing a more holistic approach to health and wellness, especially in herbal studies.
32) Ulcer:
Ulcer is mentioned as a therapeutic indication for Lagenaria siceraria, showcasing its broad medicinal applications. Researching various uses of this plant may lead to the discovery of new therapeutic properties and further validate its role in health management, expanding the knowledge base around herbal treatments.
33) Hindi (Hiṇá¸Ä«, HiṃdÄ«, Himdi, HindÄ«):
Hindi, the language in which some local names for medicinal plants are expressed, connects the study to its cultural roots. Understanding language and terminology enhances communication and comprehension of access to traditional knowledge regarding herbal medicines employed in local health practices.
34) Fever:
Fever is another condition that Lagenaria siceraria is traditionally used to address. Recognizing its various therapeutic applications validates the plant's usage in traditional medicine and opens avenues for researching its multiple benefits in treating various health issues, including urolithiasis.
35) Beta (BÄ“á¹a, Beá¹a):
Beta potentially refers to beta-carotene, a nutrient found in Lagenaria siceraria. Understanding its nutritional profile helps in appreciating its broader health benefits. Nutrients like beta-carotene may play an essential role in promoting overall health and preventing stone formation in the urinary system.
36) Food:
Food refers to the role of Lagenaria siceraria as a dietary component. Its inclusion emphasizes the nutritional aspects of medicinal plants, highlighting the ways in which diet influences health and the prevention of conditions like urolithiasis, ultimately demonstrating the link between nutrition and medicine.
37) Diet:
Diet signifies the importance of nutrition in health, particularly in preventing diseases like urolithiasis. Researching how certain dietary components influence urinary stone formation can guide effective dietary recommendations and interventions that may reduce the incidence of kidney stones in susceptible populations.
38) Rich (Ṛch):
Rich refers to the abundance of beneficial nutrients in Lagenaria siceraria. Acknowledging the nutrient density of foods and their health impacts can lead to better dietary choices and reinforce the importance of including nutrient-rich foods in the diet to promote health and prevent diseases.
Other Science Concepts:
Discover the significance of concepts within the article: �Lagenaria siceraria powder's effect on sodium oxalate urolithiasis in rats�. Further sources in the context of Science might help you critically compare this page with similair documents:
Surgical operation, Animal Ethics Committee, Renal function, Histopathology analysis, Uric acid level, Serum parameters, Anti-urolithiatic effect, Calcium oxalate crystal, Sodium oxalate, Creatinine level, Urine parameter, Lagenaria siceraria fruit powder, Urinary calculus disease, High-power laser.