Hypoglycemic and anti-hyperglycemic activity of 罢谤颈辫丑补濒腻诲颈 granules in mice
Journal name: Ancient Science of Life
Original article title: Hypoglycemic and anti-hyperglycemic activity of 罢谤颈辫丑补濒腻诲颈 granules in mice
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Ankush Gunjal, Manisha Walunj, Hetal Aghera, Mukesh Nariya, Mandip R. Goyal
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Hypoglycemic and anti-hyperglycemic activity of 罢谤颈辫丑补濒腻诲颈 granules in mice
Year: 2016
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Diabetes mellitus is a prominent global health issue marked by rising prevalence rates, from 171 million cases in 2000 to an anticipated 366 million by 2030. This metabolic disorder results from insufficient insulin secretion or ineffective insulin action, complicating treatment options. While type 1 diabetes is manageable through insulin therapy, type 2 diabetes often involves the use of various pharmacological agents, which may lead to side effects such as hypoglycemia. This has spurred interest in complementary and alternative medicine, particularly traditional herbal formulations. The Ayurvedic formulation, 罢谤颈辫丑补濒腻诲颈 办惫腻迟丑补, is recognized for its application in managing conditions similar to type 2 diabetes. This study aims to convert this formulation into granules and evaluate their hypoglycemic and anti-hyperglycemic effects in albino mice.
Hypoglycemic and Anti-Hyperglycemic Effects of 罢谤颈辫丑补濒腻诲颈 Granules
罢谤颈辫丑补濒腻诲颈 granules were administered to different groups of mice to assess their effects on blood sugar levels. The study found that in normal mice, these granules led to a significant reduction in blood sugar levels after one hour of administration, reducing levels by 27.92% compared to the control group. In hyperglycemic mice, 罢谤颈辫丑补濒腻诲颈 granules effectively lowered blood sugar levels, particularly noted after 120 minutes post-administration. The results highlighted the granules' potential as a viable alternative to conventional diabetes treatments, due to their minimal effect on lowering blood sugar levels in normal subjects while efficiently managing elevated levels in hyperglycemic conditions.
Conclusion
The findings of this research indicate that 罢谤颈辫丑补濒腻诲颈 granules exhibit significant hypoglycemic activity within the normal range and demonstrate a notable anti-hyperglycemic response during elevated blood sugar states in mice. The study suggests that these granules could serve as an alternative adjunct therapy for managing diabetes mellitus, contributing positively to blood glucose control. Given the promising results, further research involving the mechanisms of action and long-term impacts of 罢谤颈辫丑补濒腻诲颈 granules on diabetes management is warranted to substantiate their therapeutic potential.
FAQ section (important questions/answers):
What is the study focused on regarding 罢谤颈辫丑补濒腻诲颈 granules?
This study assesses the hypoglycemic and anti-hyperglycemic activity of 罢谤颈辫丑补濒腻诲颈 granules in albino mice, particularly its effects on lowering blood glucose levels.
What dosage of 罢谤颈辫丑补濒腻诲颈 granules was used in the experiments?
The dosage of 罢谤颈辫丑补濒腻诲颈 granules used in the study was 650 mg/kg administered orally to assess both hypoglycemic and anti-hyperglycemic effects.
What were the main findings regarding blood sugar levels?
罢谤颈辫丑补濒腻诲颈 granules significantly reduced blood sugar levels after one hour in normal mice and showed significant anti-hyperglycemic effects in glucose-loaded mice after two hours.
How do 罢谤颈辫丑补濒腻诲颈 granules contribute to diabetes management?
The study suggests that 罢谤颈辫丑补濒腻诲颈 granules could serve as an alternative adjuvant therapy for managing blood glucose levels in diabetic individuals, as they demonstrate both hypoglycemic and anti-hyperglycemic activities.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淗ypoglycemic and anti-hyperglycemic activity of 罢谤颈辫丑补濒腻诲颈 granules in mice鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Triphaladi (Triphala-adi):
罢谤颈辫丑补濒腻诲颈 is an Ayurvedic formulation renowned for its use in managing Prameha, a condition akin to type 2 diabetes mellitus. It consists of three fruits, each chosen for their medicinal properties. The formulation is prepared as granules to enhance taste and shelf life while maintaining its hypoglycemic effects, making it suitable for diabetic patients.
2) Blood:
In the context of diabetes and the discussed study, blood refers to the bodily fluid essential for transporting nutrients and oxygen. The regulation of blood glucose levels is critical in diabetes management. Monitoring blood sugar levels helps evaluate the effectiveness of treatments like 罢谤颈辫丑补濒腻诲颈 granules in maintaining metabolic balance.
3) Drug:
A drug is any substance used to diagnose, cure, treat, or prevent disease. In the study, drugs such as 罢谤颈辫丑补濒腻诲颈 granules and glibenclamide are administered to mice to observe their hypoglycemic and anti-hyperglycemic effects. The exploration of herbal drugs offers alternatives to conventional medicine for managing conditions like diabetes.
4) Activity:
In this text, activity primarily refers to the pharmacological effects of 罢谤颈辫丑补濒腻诲颈 granules on blood sugar regulation. Assessing these activities helps determine the efficacy of the granules in hypoglycemic and anti-hyperglycemic contexts, providing insights into their potential therapeutic roles in diabetes management.
5) Sugar:
Sugar, or glucose, is a critical energy source for the body. In diabetes research, managing blood sugar levels is vital for preventing complications. The study examines the effects of 罢谤颈辫丑补濒腻诲颈 granules on blood sugar, highlighting the importance of controlling hyperglycemia and ensuring that patients maintain balanced glucose levels.
6) Water:
Water is essential for life and is a crucial solvent in various biological and pharmaceutical processes. In the study, water is used to create the decoction, 办惫腻迟丑补, from herbal ingredients. Proper hydration is also significant in bodily functions, particularly in regulating blood sugar levels and supporting overall health.
7) Kvatha:
碍惫腻迟丑补 is a traditional Ayurvedic decoction made by boiling herbal materials in water. It serves as a potent medium for extracting the therapeutic properties of the ingredients. In this study, 办惫腻迟丑补 is transformed into granules, enhancing its usability, effectiveness, and shelf life, particularly in diabetic care.
8) Pharmacology:
Pharmacology is the study of drugs, their mechanisms of action, side effects, and therapeutic uses. Understanding the pharmacological properties of ingredients in 罢谤颈辫丑补濒腻诲颈 granules aids in evaluating their potential effectiveness in treating diabetes. This scientific discipline helps bridge traditional herbal medicine with modern therapeutic practices.
9) Ghana:
Ghana refers to the concentrated solid extract derived from 办惫腻迟丑补, achieved by reducing the decoction to a semi-solid state. This process enhances the therapeutic potency of the formulation. In the study, Ghana is mixed with other powders to create 罢谤颈辫丑补濒腻诲颈 granules, making them more effective for hypoglycemic activity.
10) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is an ancient Ayurvedic science focused on alchemy and preparations of medicinal herbs to enhance their properties. It involves processing metals and minerals for therapeutic purposes. Understanding Rasashastra is crucial in Ayurveda, as it guides the formulation and preparation of medicines like 罢谤颈辫丑补濒腻诲颈 for effective treatment.
11) Bhaishajya (Bhaisajya):
Bhaishajya translates to 'medicine' in Ayurveda, encompassing the wide array of herbal therapies available for diverse health issues. The study鈥檚 reference to Bhaishajya highlights the vital role of traditional herbal formulations like 罢谤颈辫丑补濒腻诲颈 granules in managing diseases like diabetes, thereby illustrating the integration of ancient wisdom in contemporary healthcare.
12) Prameha:
Prameha is a term used in Ayurveda denoting various conditions related to abnormal urination, particularly diabetes mellitus. The formulation of 罢谤颈辫丑补濒腻诲颈 granules is specifically aimed at managing this condition, making it relevant for individuals suffering from type 2 diabetes, and showcasing the efficacy of Ayurvedic treatments in contemporary medicine.
13) Kalpana:
Kalpana means 'preparation' in Ayurveda, referring to the various forms herbal medicines can take. In this context, Kalpana relates to the transformation of 罢谤颈辫丑补濒腻诲颈 into granules. This preparation enhances its usability and effectiveness, bridging ancient practices with modern therapeutic needs for addressing diabetes and its symptoms.
14) Pharmacological:
Pharmacological pertains to the study of the effects and mechanisms of drugs. In this article, pharmacological investigations of 罢谤颈辫丑补濒腻诲颈 granules reveal their potential hypoglycemic and anti-hyperglycemic activities. Understanding these pharmacological properties is crucial for validating herbal treatments in the framework of evidence-based medicine.
15) Discussion:
Discussion in scientific literature refers to the section where findings are interpreted and analyzed concerning existing knowledge. This section highlights the implications of the study's results, providing a platform for evaluating the therapeutic potential of 罢谤颈辫丑补濒腻诲颈 granules while suggesting future research paths and understanding complex mechanisms at play.
16) Rasakriya (Rasa-kriya):
搁补蝉补办谤颈测腻 is an Ayurvedic process involving the preparation and transformation of herbal decoctions. This technique is essential for enhancing the extraction of active compounds. In this context, 搁补蝉补办谤颈测腻 describes the methodology used to create 罢谤颈辫丑补濒腻诲颈 granules, emphasizing traditional practices that ensure the efficacy of herbal formulations in diabetes management.
17) Flavonoid:
Flavonoids are a group of phytochemicals known for their antioxidant and anti-inflammatory properties. Found in many herbal medications, including ingredients in 罢谤颈辫丑补濒腻诲颈, flavonoids may contribute to blood sugar regulation and overall health. Their presence enables traditional medicines to offer additional health benefits, particularly in managing chronic conditions like diabetes.
18) Medicine:
Medicine encompasses a broad range of practices aimed at improving health and treating diseases. In this context, it refers to both conventional pharmaceuticals and traditional remedies like 罢谤颈辫丑补濒腻诲颈 granules. Understanding medicine's evolving nature facilitates the integration of ancient practices with modern science, ultimately enhancing patient care.
19) Science (Scientific):
Science represents the systematic study of the natural world through observation and experimentation. In the context of this study, science validates the efficacy of Ayurvedic treatments like 罢谤颈辫丑补濒腻诲颈 granules through empirical research, fostering a bridge between traditional knowledge and contemporary medical understanding to ensure effective diabetes management.
20) Diet:
Diet refers to the food and drink consumed by individuals, playing a crucial role in diabetes management. In this study, diet is considered alongside pharmacological interventions. Healthy dietary practices promote better health outcomes when combined with herbal treatments like 罢谤颈辫丑补濒腻诲颈 granules, reinforcing their effects on blood sugar regulation.
21) Post:
Post refers to the time period following an event or intervention. In this context, it pertains to measuring blood sugar levels after administering 罢谤颈辫丑补濒腻诲颈 granules or glucose overload. Monitoring post-administration effects is critical for understanding the timing and effectiveness of diabetes treatments in managing blood sugar levels.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Hypoglycemic and anti-hyperglycemic activity of Triphaladi granules in mice鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Diabetes mellitus, Complementary and alternative medicine, Shelf life, Hypoglycemic activity, Ayurvedic practice, Institutional animal ethics committee, Pharmacological studies, Significant decrease, Blood sugar level, Anti-hyperglycemic activity, Dose fixation, Hyperglycemic Study, Non-Significant Decrease.