Gastroprotective effects of reconstituted red fruit pulp of Citrullus lanatus
Journal name: Ancient Science of Life
Original article title: Gastroprotective activity of reconstituted red fruit pulp concentrate of Citrullus lanatus in rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Swapnil Sharma, Vivek Dave, Sarvesh Paliwal, Jaya Dwivedi, Sonika Jain
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Gastroprotective activity of reconstituted red fruit pulp concentrate of Citrullus lanatus in rats
Year: 2014
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study focuses on the gastroprotective properties of the aqueous fruit pulp concentrate of Citrullus lanatus citroides (commonly known as watermelon) against gastric ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin and through pyloric ligation in Wistar albino rats. Gastrointestinal ulcers are major health concerns, often resulting from factors such as excessive usage of NSAIDs, stress, and infections. Synthetic drugs can offer treatment, but they frequently come with adverse side effects. In recent years, there has been a rising interest in herbal remedies that are often more accessible and have fewer side effects than pharmaceutical options.
Importance of Antioxidant Activity of Citrullus lanatus
One of the significant findings of the study is the antioxidant activity of Citrullus lanatus fruit pulp concentrate, which plays a crucial role in its gastroprotective effect. The research demonstrated that treatment with CLC resulted in a significant reduction in the ulcer index, indicating its effectiveness in healing induced gastric lesions. Additionally, the concentrate displayed a noticeable increase in the levels of enzymatic antioxidants such as superoxide dismutase (SOD) and catalase (CAT). These enzymes work to neutralize free radicals, thus mitigating lipid peroxidation and oxidative stress that contribute to gastric injury. Furthermore, the study highlighted that the presence of phytochemicals including flavonoids, polyphenols, and other antioxidant compounds are likely responsible for these protective effects.
Conclusion
Overall, the findings suggest that the aqueous fruit pulp concentrate of Citrullus lanatus has significant gastroprotective potential, making it a promising candidate for the treatment of gastric ulcers. By demonstrating both cytoprotective and anti-secretory effects, the concentrate aids in restoring gastric mucosal integrity while combating oxidative damage. This research supports the use of herbal medicines as effective alternatives to conventional drug therapies for managing gastric ulcers and encourages further investigation into isolating specific active constituents responsible for its therapeutic properties.
FAQ section (important questions/answers):
What is the aim of the study on Citrullus lanatus?
The study aimed to evaluate the gastroprotective potential of the aqueous fruit pulp concentrate of Citrullus lanatus citroides on pyloric ligation and indomethacin-induced ulcers in Wistar albino rats.
What methods were used to test the gastric protective effect?
The study employed indomethacin-induced ulcer and pyloric ligation models to assess the gastroprotective effects. The effectiveness was measured through ulcer index reduction and changes in gastric juice parameters.
What were the main results of the study?
The results showed that treatment with Citrullus lanatus led to a significant reduction in lesion index and improvement in gastric parameters, indicating its potential as an antiulcer agent against induced ulcers.
What specific components in Citrullus lanatus contribute to its gastroprotective effects?
The gastroprotective effects are attributed to phytochemical constituents such as flavonoids, polyphenols, and other compounds that provide cytoprotection and may help inhibit acid secretion.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淕astroprotective effects of reconstituted red fruit pulp of Citrullus lanatus鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ulcer:
An ulcer is a sore that forms on the lining of the stomach or intestines, often due to the imbalance in protective factors such as mucus and aggressive factors such as stomach acid. Understanding ulcers is crucial in gastroenterology, as they can lead to significant health issues if not treated properly.
2) Water:
Water is a vital element for life and is essential in many biological processes. In the context of the study, water serves as a solvent for extracting the bioactive compounds from the aqueous fruit pulp concentrate of Citrullus lanatus, helping to evaluate its gastroprotective effects on ulcers.
3) Activity:
In pharmacology, 'activity' refers to the effectiveness of a drug or extract in producing a desired therapeutic effect. The study aims to assess the gastroprotective activity of the aqueous fruit pulp concentrate of Citrullus lanatus against ulcers induced in rat models.
4) Drug:
A drug is a substance used for medical treatment. The study compares the effects of traditional remedies, such as the fruit pulp concentrate of watermelon, with synthetic drugs like ranitidine, highlighting the potential of natural products in treating conditions like gastric ulcers.
5) Sharman (Sarma, Sharma, Sarman):
Swapnil Sharma is one of the authors and researchers associated with the study. His work focuses on evaluating the therapeutic properties of natural extracts. The collaboration between researchers assures the credibility of the findings, providing valuable insights into natural remedies against gastric ulcers.
6) Phytochemical:
Phytochemicals are bioactive compounds derived from plants that contribute to their beneficial health effects. The study involves analyzing the phytochemical composition of the fruit pulp concentrate of Citrullus lanatus, aiming to correlate specific phytochemicals with observed gastroprotective activities against ulcers.
7) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant properties and potential health benefits. In the study, the presence of flavonoids in the aqueous fruit pulp concentrate is thought to play a significant role in exerting gastroprotective effects against chemically induced ulcers.
8) Jaya:
Jaya Dwivedi is an author in the study, contributing to the research focused on the gastroprotective effects of Citrullus lanatus. Her involvement, alongside other researchers, indicates a collaborative effort aimed at revealing the potential benefits of natural products in medicine.
9) Pharmacological:
Pharmacological studies investigate the effects of substances on biological systems. This research analyzes the pharmacological properties of Citrullus lanatus fruit pulp, exploring its potential medicinal applications, particularly in treating gastric ulcers through its anti-ulcer activity.
10) Glass:
In laboratory settings, glassware is commonly used for experiments, including mixing, heating, and analyzing substances. The term 'glass' may refer to the laboratory glassware used for various assays and measurements in the study involving the fruit pulp concentrate and its effects.
11) Blood:
Blood plays a crucial role in delivering nutrients and oxygen to organs and tissues. In the context of ulcer research, blood supply is essential for mucosal repair and integrity, and the study indirectly addresses how treatments might improve blood flow to gastric tissues.
12) Accumulation (Accumulating, Accumulate):
Accumulation refers to the build-up of substances within tissues or systems. In the study, it highlights how certain components, such as reactive oxygen species or anti-ulcer compounds, can accumulate and affect cellular health, influencing the progression of gastric ulcers.
13) Discussion:
The discussion in academic research evaluates findings, comparing them with prior studies and theories. In this study, the discussion section addresses how the observed effects of Citrullus lanatus on ulcers correlate with existing knowledge on phytochemicals and their pharmacological properties.
14) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine from India that emphasizes natural remedies and holistic healing. The study references Ayurvedic beliefs regarding Citrullus lanatus for digestive health, showcasing the integration of traditional wisdom in modern scientific research.
15) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing ailments. The study contributes to the field of medicine by exploring alternative treatments, such as natural extracts, specifically their efficacy against gastric ulcers, warranting further investigation into their clinical applications.
16) Science (Scientific):
Science is the systematic study of the natural world, encompassing various disciplines, including biology and pharmacology. This research exemplifies scientific inquiry by investigating the gastroprotective properties of a natural substance, contributing empirical evidence to the field of medicinal plants.
17) Madhya:
Madhya refers to Madhya Pradesh, India, where certain research activities or medicinal plants may be sourced. The geographical context can influence the accessibility, study, and application of various natural remedies, such as Citrullus lanatus, within specific cultural and ethnic medical practices.
18) Botany:
Botany is the branch of biology that deals with plant life. The reference to botany in the study signifies the importance of understanding plant characteristics and constituents, which is crucial for evaluating the pharmacological potential of herbal remedies like Citrullus lanatus.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Gastroprotective effects of reconstituted red fruit pulp of Citrullus lanatus鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Citrullus lanatus, Gastric juice, Herbal medicine, Gastrointestinal Tract, Phytochemical analysis, Reactive oxygen species, Institutional Animal Ethical committee, Total acidity, Lipid peroxide, Pyloric ligation, Antiulcer activity, Gastroprotective Activity, Spectrophotometer, Indomethacin induced ulcer, Gastroprotective effect, Department of Pharmacy, Enzymic antioxidants, Cytoprotective potential, Wistar albino rat, Alkaloids, flavonoids, polyphenols.