Quality, fatty acid profile, and umbelliferone in grahaṇimihira tailam.
Journal name: Ancient Science of Life
Original article title: Quality parameters, fatty acid profiling and estimation of umbelliferone in grahaṇimihira tailam: An ayurvedic oil preparation
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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M. Deepak, Prakash U. Kumar, B. Nitha, Indira Balachandran, A B Rema Shree
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Quality parameters, fatty acid profiling and estimation of umbelliferone in grahaṇimihira tailam: An ayurvedic oil preparation
Year: 2013
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Grahaṇimihira tailam, an ayurvedic oil preparation featuring 34 ingredients with a sesame oil base, is recognized for its diverse therapeutic applications, including treatment for gastrointestinal ailments, respiratory issues, and skin conditions. Despite its traditional significance, there has been limited research on establishing standardization parameters for this formulation. The authors aimed to develop a comprehensive set of standards through multidimensional analysis, addressing the need for quality control in ayurvedic products.
Fatty Acid Profiling and Umbelliferone Quantification
The study implemented high-performance thin layer chromatography (HPTLC) for the quantification of umbelliferone, an active compound known for its antioxidant properties, while gas chromatography-mass spectrometry (GC-MS) was employed to profile fatty acids present in the formulation. The research revealed umbelliferone content ranging from 0.88% to 0.98% (w/w) across different batches and identified a total of 14 fatty acids, predominantly linoleic acid (43%) followed by palmitic acid (20.6%). Additional evaluations ensured that the formulation was free from microbial contamination, aflatoxins, and mineral oils, confirming its purity and quality.
Conclusion
The findings from this study present a systematic approach for the standardization of Grahaṇimihira tailam, including established protocols for umbelliferone quantification and fatty acid profiling. The developed methods and documented physico-chemical properties are essential for ensuring product quality and consistency, paving the way for further research and potentially greater recognition of this traditional ayurvedic medicine. Additionally, the absence of harmful contaminants affirms the safety and efficacy of the formulation, contributing to its clinical validation and acceptance.
FAQ section (important questions/answers):
What is Grahaṇimihira Tailam and its primary uses?
Grahaṇimihira Tailam is an Ayurvedic oil preparation with 34 ingredients. It treats conditions like diarrhea, asthma, jaundice, and promotes overall wellness. Its efficacy is attributed to its traditional formulation and active compounds.
How was umbelliferone quantified in the study?
Umbelliferone was quantified using a validated High Performance Thin Layer Chromatography (HPTLC) method. Samples were extracted with methanol, and the analysis was performed at 325 nm to determine its concentration in the tailam.
Which fatty acids were identified in Grahaṇimihira Tailam?
The study identified 14 fatty acids, with linoleic acid (43%) being the most abundant. Other significant fatty acids included palmitic acid (20.6%) and myristic acid (8.9%), contributing to the oil's nutritional profile.
What safety assessments were conducted on Grahaṇimihira Tailam?
The formulation was tested for microbiological contamination, aflatoxins, and mineral oils. Results showed no contamination with harmful microbes or aflatoxins, indicating the safety and quality of the tailam.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Quality, fatty acid profile, and umbelliferone in grahaṇimihira tailam.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Vaidya:
Vaidya refers to a practitioner of Ayurveda, the traditional system of medicine from India. They are knowledgeable in herbal remedies, therapies, and medicinal preparations. In the context of the study, Vaidya reflects the expertise involved in creating and standardizing Ayurvedic formulations like grahaṇimihira tailam, ensuring efficacy and safety.
2) Shala (Sala):
Sala is a term often associated with institutions or organizations focused on promoting health and wellness. In this context, Arya Vaidya Sala refers to a renowned Ayurvedic institution in Kerala, India, dedicated to the practice and research of traditional medicine, including the preparation and analysis of herbal oils.
3) Quality:
Quality refers to the inherent characteristics of a product, including its reliability and performance. In the study, establishing quality parameters is crucial for standardizing grahaṇimihira tailam, ensuring it meets specific morphological, chemical, and biological specifications, thereby facilitating its acceptance in both traditional and modern medicinal contexts.
4) Drug:
A drug is any substance used for the diagnosis, cure, treatment, or prevention of disease. In the study, the Ayurvedic formulation grahaṇimihira tailam is evaluated for its medicinal properties, safety, and effectiveness, showcasing its potential use as a therapeutic agent within integrative medicine.
5) Medicine:
Medicine encompasses the art and science of healing. It includes various disciplines and practices aimed at preserving and restoring health. The study emphasizes the significance of Ayurvedic medicine, particularly through the standardization of its formulations, ensuring they are effective, safe, and widely recognized in health care.
6) Shri (Sri, Sr):
Shree is a respectful honorific used in Indian culture, often denoting honor, prosperity, or reverence. In the context of this article, it is part of Dr. A B Rema Shree's name, highlighting her position and respect within the research community, as she contributes to Ayurvedic drug standardization.
7) Water:
Water is a fundamental solvent and an essential component in many chemical reactions, including those in herbal preparations. In the study, water is used for the extraction of compounds from the grahaṇimihira tailam formulation, demonstrating its importance in the preparation and analysis of Ayurvedic medicines.
8) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their medicinal properties. The study focuses on identifying these compounds in grahaṇimihira tailam, as understanding their presence and concentration is essential for establishing quality parameters and therapeutic efficacy in Ayurvedic formulations.
9) Ayus (Ayush):
Ayush stands for Ayurveda, Yoga, Unani, Siddha, and Homeopathy. It represents the traditional systems of medicine in India. The study's relevance to Ayush includes its aim to standardize Ayurvedic formulations, aligning them with national health policies and promoting holistic health practices within the Indian health care system.
10) Discussion:
Discussion refers to the analysis and interpretation of study results. In this article, discussions are centered around the findings from quality assessments of grahaṇimihira tailam, comparing them to established standards, facilitating a deeper understanding of the formulation's properties and its potential for broader medicinal use.
11) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant properties and potential health benefits. The study investigates the presence of flavonoids in grahaṇimihira tailam as part of evaluating its therapeutic value, contributing to understanding the formulation's effects on health conditions.
12) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine that originated in India, focusing on holistic wellness and natural healing. This study underscores its significance by exploring the quality and efficacy of Ayurvedic formulations, promoting their validation and recognition in the modern health sector.
13) Vertigo:
Vertigo is a medical condition characterized by a sensation of spinning or dizziness. The study mentions it among the ailments treated by grahaṇimihira tailam, illustrating the formulation's therapeutic applications and signifying its importance in addressing various health issues as part of Ayurvedic practice.
14) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. The study employs scientific methods to evaluate and standardize the Ayurvedic formulation, applying rigorous analytical techniques to ensure the formulation's quality, safety, and effectiveness in medicinal use.
15) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth. The study discusses the potential role of compounds like umbelliferone in cancer prevention, highlighting the importance of traditional remedies in modern therapeutic strategies and their contribution to cancer research and management.
16) Edema (Oedema):
Edema refers to the swelling caused by excess fluid trapped in the body's tissues. It is mentioned in the context of ailments treated with grahaṇimihira tailam. Understanding its therapeutic effects helps to validate the formulation's applications in traditional medicine, addressing common health concerns.
Other Science Concepts:
Discover the significance of concepts within the article: �Quality, fatty acid profile, and umbelliferone in grahanimihira tailam.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Physico-chemical parameters, High performance thin layer chromatography, Microbial Contamination, Gas Chromatography Mass Spectrometry, Standardization parameter, Phyto-constituent, Aflatoxin assay, Batch-to-batch variation.