Effect of Achyranthes aspera extracts on inflammation in animals.
Journal name: Ancient Science of Life
Original article title: Effect of aqueous extracts of Achyranthes aspera Linn. on experimental animal model for inflammation
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Uma A. Bhosale, Radha Yegnanarayan, Prachi Pophale, Rahul Somani
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Effect of aqueous extracts of Achyranthes aspera Linn. on experimental animal model for inflammation
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Achyranthes aspera Linn., commonly known by various regional names such as Chirchita in Hindi and Apamarga in Sanskrit, is a wild tropical plant recognized for its significant medicinal properties. It has been traditionally employed in Indian folk medicine for treating a variety of ailments, including cough, bronchitis, diabetes, and rheumatism. The current study aimed to investigate the anti-inflammatory activity of aqueous extracts derived from A. aspera (AEAA) using an experimental model of inflammation in albino mice.
Anti-inflammatory Efficacy of Aqueous Extracts
The study utilized two forms of AEAA: aqueous extracts of the leaves and the whole plant. Employing carrageenan-induced edema model in mice, the researchers measured the anti-inflammatory effectiveness of various doses (400 mg/kg and 800 mg/kg). Results demonstrated a noteworthy reduction in paw edema, particularly notable at the 800 mg/kg dosage, which exhibited a significant decrease in inflammation compared to control and standard diclofenac sodium treatments. The presence of phytoconstituents such as flavonoids, alkaloids, saponins, and triterpenoids in the extracts was correlated to the observed anti-inflammatory effects. This indicates potential dual inhibition of the inflammation pathway by the extracts, targeting both early and late phases of the inflammatory response.
Conclusion
The findings of the study suggest that the aqueous extracts of Achyranthes aspera have promising anti-inflammatory properties, primarily attributed to its rich phytochemical composition. The significant anti-inflammatory activity noted in the experimental models highlights the therapeutic potential of A. aspera as a natural treatment option for chronic inflammatory conditions, such as arthritis. Further research is necessary to isolate and purify the specific bioactive compounds within the plant for enhanced efficacy and applicability in medical treatments.
FAQ section (important questions/answers):
What is the main focus of the study on Achyranthes aspera?
The study evaluates the anti-inflammatory activity of aqueous extracts from Achyranthes aspera in experimental animal models, specifically focusing on its effects against carrageenan-induced paw edema in albino mice.
What type of extracts were used in the anti-inflammatory study?
The study used aqueous extracts from the leaves and whole plant of Achyranthes aspera, specifically known as AEAA and its constituents evaluated for their anti-inflammatory properties.
What were the main findings regarding the anti-inflammatory effect?
The aqueous extracts significantly reduced paw edema by 35.71-54.76%, particularly at doses of 400 mg/kg and 800 mg/kg, showing a dose-dependent increase in anti-inflammatory activity compared to the untreated control group.
What phytochemicals were identified in Achyranthes aspera extracts?
The extracts contained flavonoids, alkaloids, saponins, and triterpenoids, with specific components identified through HPTLC analysis, which likely contribute to their anti-inflammatory properties.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of Achyranthes aspera extracts on inflammation in animals.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The study evaluates the anti-inflammatory activity of aqueous extracts from Achyranthes aspera. This activity is significant because it highlights the potential medicinal benefits of the plant, particularly in treating inflammation. The observed activity supports its use in traditional medicine for similar ailments.
2) Edema (Oedema):
Edema refers to the swelling caused by fluid accumulation, which is central to the study. The study measures the degree of paw edema induced by carrageenan to assess the anti-inflammatory effects of the extracts. A reduction in edema indicates effective anti-inflammatory properties.
3) Phytochemical:
Phytochemical analysis reveals the presence of bioactive compounds in Achyranthes aspera extracts. These phytochemicals, such as flavonoids and alkaloids, contribute to the plant’s medicinal properties and the observed anti-inflammatory activity. Understanding phytochemicals is crucial in evaluating plant-based therapies.
4) Flavonoid:
Flavonoids are a class of phytochemicals present in the analyzed extracts, contributing significantly to their anti-inflammatory activity. Their existence in Achyranthes aspera supports the plant's traditional use in medicine. Flavonoids are known for various health benefits, including reducing inflammation.
5) Toxicity:
Toxicity assessments ensure the safety of the extracts at different dosages. The study confirms the toxicity threshold for Achyranthes aspera extracts, highlighting that the toxic dose exceeds 2000 mg/kg. This understanding is essential for therapeutic application of natural products.
6) Pharmacology:
Pharmacology plays a crucial role in evaluating Achyranthes aspera's effects on inflammation. The study provides insights into how the extracts mediate biological activities, contributing to the pharmacological knowledge of traditional medicinal plants and their potential integration into modern medicine.
7) Inflammation:
Inflammation is the primary condition being studied, wherein the aqueous extracts of Achyranthes aspera are tested for their ability to reduce inflammatory responses, as seen in carrageenan-induced edema. This relevance underscores the plant's potential in treating inflammatory disorders.
8) Water:
Water is the solvent used for extracting phytochemicals from Achyranthes aspera. The extraction process is critical for dissolving active components, thereby allowing the study to assess their biological activity in the context of inflammation.
9) Drug:
In the context of the study, a drug refers to substances like the aqueous extracts from Achyranthes aspera that can potentially be used in treating conditions like inflammation. Understanding the drug-like properties of these extracts is essential for their therapeutic application.
10) Apamarga:
Apamarga is one of the traditional names for Achyranthes aspera, reflecting its cultural and medicinal significance in various regions. It emphasizes the plant’s historical use in Indian medicine and its relevance in phytotherapy and herbal remedies.
11) Nayurivi:
Nayurivi is another traditional name for Achyranthes aspera within local herbal medicine systems. Recognizing such names contextualizes the plant's use across different cultures and emphasizes its importance in traditional practices.
12) Medicine:
The study highlights Achyranthes aspera's importance in indigenous medicine systems such as Ayurveda, showcasing its potential as an alternative therapeutic option for treating inflammation and other health issues.
13) Antibiotic (Antibacterial):
Antibacterial properties, although not the primary focus of this study, indicate the potential additional applications of Achyranthes aspera beyond inflammation. If confirmed, this aspect could enhance the therapeutic profile of the plant in pharmacology.
14) Discussion:
The discussion section of the study elaborates on the significance and implications of the findings regarding Achyranthes aspera's anti-inflammatory activity. It connects results with existing literature and posits future research directions.
15) Substance:
The term substance is relevant as it refers to the active components extracted from Achyranthes aspera. Identifying these substances is essential for understanding their roles in pharmacological activity and potential medicinal benefits.
16) Obsession:
Obsession here relates to the modern focus on exploring traditional medicine, indicating a growing interest in ancient healing systems as alternatives to synthetic drugs, particularly in dealing with chronic conditions such as inflammation.
17) Ayurveda (Ayus-veda):
Ayurveda, a traditional Indian system of medicine, is highly relevant to the study as it incorporates plants like Achyranthes aspera for treating various ailments, including inflammation, thus rooting the research in traditional therapeutic knowledge.
18) Allergy:
The potential of Achyranthes aspera extracts to address inflammation has implications for allergy treatment due to their ability to modulate inflammatory responses. This connection opens avenues for further research into managing allergy symptoms through traditional methods.
19) Science (Scientific):
The scientific exploration of Achyranthes aspera underscores the importance of rigorous testing and validation of traditional medicines. The study employs methods grounded in scientific research to assess the plant's medicinal properties.
20) Siddha:
Siddha is another ancient healing tradition from India that uses herbal remedies, including those from Achyranthes aspera. Its inclusion emphasizes the plant's broad relevance in traditional therapeutic systems.
21) Vijaya:
Vijaya refers to a researcher who previously studied the anti-inflammatory effects of Achyranthes aspera, providing a basis for comparison with current findings and supporting the ongoing exploration of the plant's medicinal qualities.
22) Reason:
The reason for this study is to evaluate the anti-inflammatory potential of Achyranthes aspera extracts scientifically. Validating such traditional uses through research provides a compelling rationale for their continued use in modern medicine.
Other Science Concepts:
Discover the significance of concepts within the article: �Effect of Achyranthes aspera extracts on inflammation in animals.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Achyranthes aspera, Statistical analysis, Different name, Anti-inflammatory activity, Experimental study, Traditional systems of medicine, Aqueous extract, Acute toxicity study, Institutional animal ethics committee, High performance thin layer chromatogram, Carrageenan-induced edema, Department of Pharmacology, Experimental Animal Model, Open access article.