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Efficacy of Tulsi vs. Oxitard in managing oral submucous fibrosis

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Comparative study on efficacy of tulsi and oxitard in the management of oral submucous fibrosis (osmf)
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Thomas Twinkle and Hegde Sushmini


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Comparative study on efficacy of tulsi and oxitard in the management of oral submucous fibrosis (osmf)

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20241-30753

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Oral submucous fibrosis (OSMF) is a chronic, debilitating condition often associated with areca nut chewing, predominantly affecting populations in South and South East Asia. Characterized by progressive fibrosis and resulting loss of mouth opening, OSMF poses serious health risks, including a potential for malignant transformation. Various medical and herbal treatments have been explored for their efficacy in managing OSMF. This study compares the effectiveness of Tulsi (Ocimum sanctum) and Oxitard, two herbal remedies, in treating patients with clinically diagnosed OSMF.

Efficacy of Tulsi in Managing Symptoms

Tulsi, known for its medicinal properties, was administered to Group I patients in the study at a dosage of 500 mg twice daily for three months. The results showed statistically significant improvements in burning sensation, with patients experiencing a reduced mean score on the Visual Analogue Scale (VAS) from a baseline of 5.60 to 1.77 after 90 days. This suggests that Tulsi is highly effective in alleviating discomfort associated with OSMF, likely due to its analgesic properties attributed to its high eugenol content which inhibits inflammatory mediators.

Impact of Oxitard on Functional Parameters

Oxitard, provided to Group II patients at a similar dosage, showed remarkable improvements in functional parameters of OSMF. After three months, mouth opening, cheek flexibility, and tongue protrusion were assessed, with significant enhancements noted. Specifically, the mean interincisal distance improved from 33.82 mm to 41.58 mm in Group II, indicating a substantial increase in mouth opening. This underscores Oxitard’s role not only in symptom management but also in restoring functional capabilities affected by OSMF.

Comparative Analysis of Treatment Effects

The study reveals that while Tulsi effectively reduces burning sensation, Oxitard is superior in improving functional aspects like mouth opening and tongue movement. Statistically significant differences were noted in the improvement of cheek flexibility and tongue protrusion, with Group II patients exhibiting more pronounced gains. For instance, tongue protrusion improved from 38.89 mm to 42.40 mm in Oxitard patients, highlighting its therapeutic potential in enhancing oral functionality, a crucial aspect of OSMF management.

Conclusion

This comparative study highlights the promising efficacy of both Tulsi and Oxitard in managing OSMF. While Tulsi demonstrates significant benefits in alleviating burning sensations, Oxitard excels in enhancing functional parameters such as mouth opening and tongue mobility. The findings suggest that these herbal treatments can serve as effective, non-invasive alternatives to conventional therapies, warranting further research with larger samples and extended follow-up periods to fully establish their therapeutic roles in OSMF management.

FAQ section (important questions/answers):

What is Oral Submucous Fibrosis (OSMF) and its causes?

OSMF is a chronic condition linked to areca nut chewing, marked by fibrosis and inflammation in the oral cavity. Causes include nutritional deficiencies, genetic factors, and autoimmune reactions.

How was the study on Tulsi and Oxitard conducted?

Ninety OSMF patients were randomly assigned to two groups. One group received Tulsi tablets while the other received Oxitard tablets for three months, with follow-up assessments at intervals.

What were the main findings regarding burning sensation relief?

The study found that Tulsi significantly reduced burning sensation compared to Oxitard, with a marked improvement noted at 90 days in patients taking Tulsi.

Which treatment showed better improvement for mouth opening and flexibility?

Oxitard resulted in significantly better improvements in mouth opening and cheek flexibility, with patients showing greater enhancement in these parameters compared to those taking Tulsi.

What conclusions were drawn about Tulsi and Oxitard's effectiveness?

Both Tulsi and Oxitard were effective in managing OSMF symptoms. Tulsi reduced burning sensations while Oxitard improved mouth opening, cheek flexibility, and tongue protrusion.

What future research does the study suggest?

The study recommends further research with larger sample sizes and extended follow-up periods to better assess the efficacy of Tulsi and Oxitard in treating OSMF.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of Tulsi vs. Oxitard in managing oral submucous fibrosis�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The study signifies the research endeavor aimed at comparing the effects of Tulsi and Oxitard on patients with OSMF. Its findings are instrumental in guiding future treatments and understanding the potential role of herbal remedies in managing this challenging condition.

2) Tulsi:
Tulsi, known as Ocimum sanctum, is a herb extensively used in traditional medicine for its potential therapeutic properties. In this study, Tulsi's efficacy is compared to Oxitard in alleviating symptoms of Oral Submucous Fibrosis, highlighting its relevance in holistic health approaches and promoting natural healing.

3) Burning sensation:
Burning sensation is a common symptom experienced by OSMF patients, often indicating inflammation or irritation within the oral cavity. Assessing changes in burning sensation provides significant insight into treatment efficacy, as it affects patients' quality of life and capacity to perform daily functions without discomfort.

4) Burning (Burn, Burned, Burnt):
The term 'Burning' relates specifically to the unpleasant and painful sensation reported by patients suffering from OSMF. It serves as a vital parameter in clinical assessments, where any reduction post-treatment can signify improvement, thereby validating the efficacy of the therapeutic interventions being studied.

5) Medicine:
In this study, 'Medicines' denote both conventional and herbal treatments evaluated for their effectiveness in managing OSMF. Investigating different types of medicines emphasizes the importance of diverse therapeutic approaches in addressing complex medical conditions.

6) Table:
Tables within the study present vital data, including statistical comparisons between treatment groups and baseline metrics. These organized formats aid in visual comparisons and allow for clear communication of results regarding patient outcomes and treatment efficacy over time.

7) Disease:
Diseases in this context refer to a range of pathological conditions, with OSMF being a highlighted concern. Understanding the broader spectrum of diseases helps contextualize OSMF within public health and treatment strategies.

8) Male:
The term 'Male' highlights the gender distribution in the study, where a significant majority of subjects were men. This demographic information is crucial for establishing patterns in disease prevalence and tailoring future interventions that consider gender-specific factors in health.

9) Samtosha (Samtosa, Santosa, Santosha, Santosh):
Santosh is one of the researchers whose findings are referenced in the study, contributing to the broader literature on OSMF and herbal treatments. His work reinforces the reliability of the current study by establishing a context within previous research outcomes.

10) Patil:
Patil is another researcher cited in the context of various treatment interventions for OSMF. His contributions and studies provide foundational support for the exploration of herbal remedies and reinforce ongoing research efforts in this area of oral medicine.

11) Indian:
Indians refers to the population group predominantly affected by OSMF, signifying the need for targeted research in this demographic context. Recognizing population-specific health issues ensures that treatment approaches are culturally and regionally relevant.

12) Ocimum sanctum:
Ocimum sanctum, commonly known as Tulsi, is a key subject of this study. It is explored for its herbal properties that may alleviate symptoms of OSMF, underlining the significance of traditional medicine in contemporary therapeutic settings.

13) Palani (Pazhani):
Palani is mentioned as a contributing researcher in the field of OSMF treatment. His work adds credibility to the ongoing discourse around managing oral fibrous conditions and exploring effective treatment modalities, especially those involving herbal medicines.

14) Sharman (Sarma, Sarman, Sharma):
The name Sharma refers to one of the authors whose research findings support the efficacy of herbal treatments for OSMF. Incorporating various researchers� work enriches the study's background, offering comprehensive insights into potential therapeutic approaches.

15) Cancer:
Cancer is highlighted in relation to OSMF's malignant potential, where the disease can progress to oral cancer. Understanding this relationship emphasizes the urgency of effective management strategies and the critical nature of timely intervention in disease prevention.

16) India:
India is the primary geographic focus of this study, given its higher prevalence of OSMF among the population. The local context underscores the significance of researching culturally relevant treatments, promoting health initiatives specific to regional oral health challenges.

17) Kumar:
Kumar is referenced as a researcher contributing background information and previous findings related to OSMF and its treatments. Acknowledging various contributors helps validate the study’s premise and reinforces the importance of collaborative research in this domain.

18) Blood:
The term 'Blood' may refer to the implications of vascular health in OSMF. Understanding how blood flow and microcirculation affect healing in fibrotic tissues is essential for developing therapeutic measures that promote better outcomes for patients.

19) Sign:
In the context of health, 'Sign' refers to observable indicators of a disease or condition. In this study, signs may include clinical symptoms assessed during patient evaluations, which help gauge treatment efficacy and monitor disease progression.

20) Reason:
The term 'Reason' highlights the rationale behind the study's investigations into OSMF treatments. Understanding the motivations for exploring herbal medicinal options is crucial for addressing effective healthcare needs in affected populations.

21) Queen:
The repetitive mention of the term 'Queen,' particularly in reference to Tulsi as 'the queen of herbs,' emphasizes its preeminent place in herbal medicine. This characterization fosters appreciation for its therapeutic value in managing OSMF.

22) Transformation (Transform, Transforming):
Transformation pertains to the progression of OSMF, which can lead to debilitating changes in the oral cavity. The study examines ways to prevent or reverse this transformation through effective herbal treatments, highlighting the importance of timely intervention.

23) Pharmacology:
Pharmacology is relevant in understanding how herbal treatments, such as Tulsi and Oxitard, interact within the body to exert therapeutic effects on OSMF. This knowledge can improve treatment efficiency and promote safe use of herbal remedies.

24) Inflammation:
Inflammation is a key factor in OSMF and is associated with discomfort among patients. Evaluating treatments for their anti-inflammatory effects helps determine their efficacy in reducing symptoms and improving patients' quality of life during management.

25) Discussion:
The Discussion section of the study consolidates findings and connects them to existing literature, highlighting the implications of the research. It provides an opportunity to interpret the results critically and formulate future directions for studies in OSMF treatment.

26) Toxicology:
Toxicology examines the safety profile of substances, including herbal remedies. Understanding potential toxicities is essential in evaluating the use of Tulsi and Oxitard in clinical settings, ensuring that treatments are both effective and safe for patient use.

27) Substance:
The term 'Substance' may refer broadly to any material used in treatment protocols. Clarifying which substances are effective for OSMF is essential for establishing credible and reliable treatment guidelines in future healthcare practices.

28) Education:
Education plays a crucial role in informing patients about OSMF, its risks, and management strategies. The study emphasizes counseling patients about lifestyle modifications, helping them understand health implications and promoting proactive management of the disease.

29) Swallowed:
The term 'Swallowed' refers to the actions of patients regarding their consumption of areca nut, which links to the disease's development. Understanding patients' habits is vital for addressing root causes and promoting behavioral changes in treatment plans.

30) Sindhuja (Sindhu-ja, Simdhuja):
Sindhuja is mentioned as a researcher contributing to the field of herbal treatments in oral health. Identifying diverse contributions from various researchers lends credibility and depth to the study’s findings and interpretations regarding treatment efficacy.

31) Pregnant:
Pregnant individuals are identified in the exclusion criteria of the study, acknowledging specific health considerations when evaluating treatments for OSMF. Ensuring safety for vulnerable populations is paramount in designing any health intervention or clinical trial.

32) Science (Scientific):
Science constitutes the empirical approach taken in this study, emphasizing the importance of evidence-based research in investigating herbal remedies and their potential effectiveness in treating oral health conditions like OSMF.

33) Tulasi:
Tulasi, another name for Tulsi, underscores its cultural significance in Indian traditional medicine. This term highlights the herbal remedy's role in managing OSMF while acknowledging its historical and medicinal importance in local practices.

34) Mathura (Mathur):
Mathur is cited as a researcher who has contributed to understanding cheek flexibility measurements in the study of OSMF. His work provides context and credibility to the methods used in evaluating treatment efficacy in this particular condition.

35) Nagesha (Nagesa, Nagesh, Naga-isha):
Nagesh is referenced as part of the methodology in assessing cheek flexibility and oral health metrics. Citing Nagesh's research supports the robustness of the study's findings and emphasizes standardized methods in clinically evaluating OSMF treatments.

36) Visit:
Visit refers to the in-clinic consultations that are part of the study's design. These visits allow researchers to gather data on treatment effects over time, offering insight into the ongoing management of OSMF and patient experiences.

37) Thomas:
Thomas is among the authors conducting the study. His contributions help shape the research's direction and signify collaboration among professionals to advance knowledge of effective treatments for OSMF.

38) Banda (Bamda):
Banda is mentioned in the context of previous studies concerning the treatment of OSMF. Acknowledging multiple researchers fosters a comprehensive understanding of the treatment landscape and highlights gaps the current study aims to address.

39) Drug:
Drug signifies any therapeutic agent used in the management of diseases, including both conventional and herbal formulations. Understanding the mechanisms and efficacy of different drugs broadens the scope of treatment possibilities in managing OSMF.

40) Giri:
Giri is referenced as a researcher involved in the exploration of therapeutic agents for OSMF. Acknowledging his contributions enriches the study, demonstrating collaborative efforts in advancing knowledge on herbal treatments and their implications.

41) Atri (Atr, Attr, Attri):
Atri is mentioned in relation to broader pharmacological discussions surrounding herbal remedies. Citing Atri's research reinforces the credibility of the textual references about herbal medicines in the context of treating conditions like OSMF.

42) Devi:
Devi is mentioned as a contributor to the body of research surrounding herbal applications in medicine. Including her perspective emphasizes the collaborative nature of research in this field while enhancing understanding of OSMF treatments.

43) Natu (Nate):
Natu references an author whose research may underline studies on the integration of herbal remedies within conventional medicine. Recognizing contributions from various individuals lends authenticity to the study's findings on effective treatments for OSMF.

44) Alam (Ala�):
Alam's mention underscores contributions to understanding the therapeutic benefits of herbal remedies in clinical practice, particularly regarding OSMF treatment. Acknowledging diverse authors broadens the perspective on findings and enhances the study's credibility.

45) Sah:
Shah is noted in the context of contributing research that supports the understanding of treatments for OSMF. His work provides valuable insights reinforcing the need for diverse approaches in managing oral health conditions.

46) Line:
Line may refer to the specific methodology or guidelines outlined in the study. Emphasizing adherence to established practices is vital for ensuring research integrity and fostering reliable outcomes in clinical studies.

47) Milk:
Milk can refer to dietary considerations or adjunct therapies mentioned in the context of managing OSMF. Exploring various substances that contribute to overall health and recovery is pertinent for developing comprehensive treatment plans.

Other Science Concepts:

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Discover the significance of concepts within the article: �Efficacy of Tulsi vs. Oxitard in managing oral submucous fibrosis�. Further sources in the context of Science might help you critically compare this page with similair documents:

Burning sensation, Treatment modalities, Supportive treatment, Herbal medicine, Informed consent, Follow-up, Age-group, Sample size, Statistically Significant, Inclusion and exclusion criteria, Visual analogue scale, Research article, Herbal Medication, Clinical improvement, Interincisal distance, Oral submucous fibrosis, Mean age, Chronic debilitating condition, Eating habit, Tongue protrusion.

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