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Liquorice mouth rinse effects on plaque and gingivitis: a trial

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Journal name: Journal of Indian Society of Periodontology
Original article title: Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis � A randomized controlled clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Sakshi Sharma, Girish M. Sogi, Vipin Saini, Tulshi Chakraborty, Jasneet Sudan


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis � A randomized controlled clinical trial

Year: 2022 | Doi: 10.4103/jisp.jisp_517

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The rising global trend towards the use of natural herbal products stems from their affordability, cultural acceptability, compatibility with the human body, and minimal side effects. This study aimed to investigate the effectiveness of liquorice root extract as a mouth rinse in reducing dental plaque and gingivitis, comparing it to the widely used antiseptic chlorhexidine (CHX) gluconate. Through a four-month randomized controlled trial involving 44 healthy volunteers aged 18-30 with moderate gingivitis, the study aimed to provide insights into herbal alternatives for dental care.

Herbal Efficacy: Liquorice vs. Chlorhexidine

Results indicated that both liquorice and CHX mouth rinses produced a statistically significant reduction in plaque and gingival indices after a 15-day follow-up, with the chlorhexidine group showing a more considerable decrease compared to the liquorice group. The antimicrobial properties of liquorice, attributed to its key bioactive compounds like glycyrrhizin, were confirmed through initial in vitro assessments against periodontal pathogens. While both mouth rinses demonstrated effectiveness, the superior performance of CHX was linked to its substantive properties, which prolong its action in the oral cavity. Nonetheless, the study highlighted the potential of liquorice as a promising adjunct for dental hygiene, especially considering the adverse effects associated with long-term CHX use.

Conclusion

The findings advocate for the incorporation of liquorice root extract mouth rinse as an effective self-care strategy in managing plaque and gingivitis while addressing the drawbacks of prolonged chlorhexidine use. The study emphasizes the therapeutic value of herbal preparations in dental health, offering an avenue for preventive care in regions with limited access to chemical formulations. Future research could further establish the long-term effectiveness of liquorice in dental hygiene and explore its applications in various formulations beyond mouthwashes.

FAQ section (important questions/answers):

What natural products were investigated for reducing dental plaque?

This study assessed the effectiveness of liquorice root extract and compared it with 0.2% chlorhexidine gluconate mouth rinse in reducing dental plaque and gingivitis.

What was the duration and design of the clinical trial?

The trial was a double-blind, concurrent parallel randomized controlled clinical trial lasting four months, involving 44 healthy volunteers with moderate gingivitis.

How effective were the mouth rinses in the study?

Both liquorice and chlorhexidine mouth rinses showed statistically significant reductions in plaque and gingival index scores after 15 days of use.

What advantages does liquorice mouth rinse offer compared to chlorhexidine?

Liquorice mouth rinse may be an effective self-care therapy with fewer known side effects than long-term chlorhexidine use, making it a potentially safer alternative.

What were the main findings regarding the mouth rinses' effects?

Both mouth rinses reduced plaque accumulation and gingival inflammation, but chlorhexidine showed a statistically greater effectiveness in reduction compared to liquorice.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Liquorice mouth rinse effects on plaque and gingivitis: a trial�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In scientific literature, tables are critical for presenting data succinctly. They allow researchers to organize results from studies, such as the mean scores of indices used to measure dental hygiene. Tables make it easier for readers to evaluate and compare findings, ultimately aiding in data interpretation and research clarity.

2) Liquorice (Licorice):
Liquorice, or Glycyrrhiza glabra, is a key herbal ingredient studied for its therapeutic properties. It has been used historically in various medicinal practices. Recent research highlights its antibacterial and anti-inflammatory effects, making it relevant in oral health treatments, particularly for plaque control and gingivitis compared to traditional mouth rinses.

3) Study (Studying):
The term 'study' denotes a systematic investigation aimed at acquiring knowledge. In the context provided, the study evaluates the efficacy of liquorice mouth rinse versus chlorhexidine for dental health. This comparative analysis is foundational in informing clinical practices and guiding further research on herbal remedies in oral hygiene.

4) Disease:
In medical terminology, 'disease' refers to a pathological condition affecting the body or mind. The study addresses periodontal diseases, which can lead to tooth loss. Understanding diseases is essential for developing effective treatments, making this research relevant for prevention and management in dental practices and healthcare settings.

5) Inflammation:
Inflammation is the body's response to injury or infection, often causing redness, swelling, and pain. The study investigates gingival inflammation, a common issue in periodontal disease. By analyzing the anti-inflammatory properties of liquorice, researchers aim to understand its potential benefits in reducing gingivitis and promoting oral health.

6) India:
India, a country with rich herbal traditions, is the study's geographical focus. The relevance lies in exploring local remedies like liquorice within the modern medical framework. This investigation contributes to the growing interest in herbal medicine and its applications in public health, especially in developing nations.

7) Measurement:
Measurement is central in research for quantifying variables. In this context, it involves the assessment of gingival and plaque indices. Accurate measurement is vital for evaluating treatment efficacy, ensuring the reliability and validity of study findings, and facilitating comparisons across similar trials in dental health research.

8) Rules:
In scientific research, rules refer to established guidelines for conducting studies, including ethical considerations and methodological standards. The study adheres to such rules to ensure reliable results. Compliance with rules enhances the credibility and acceptance of findings in the broader scientific community, guiding future research.

9) Activity:
Activity in this context pertains to the biological actions or effects of substances, such as the antibacterial activity of liquorice extracts against periodontal pathogens. Understanding these activities is crucial for determining the effectiveness of natural remedies in preventing or treating diseases, particularly in dental care.

10) Science (Scientific):
Science is the systematic pursuit of knowledge through observation and experimentation. This study exemplifies scientific inquiry by investigating herbal solutions for dental health. By merging traditional knowledge with contemporary methods, it contributes to the broader application of scientific principles in alternative medicine and oral hygiene practices.

11) Indian:
The term 'Indian' highlights the cultural and historical context of the study. It celebrates the rich heritage of traditional medicine practices in India, such as the use of liquorice. Understanding indigenous practices provides insights into alternative treatments and encourages respect for traditional knowledge in modern healthcare.

12) Karnataka:
Karnataka, a state in India, is the study's operational base. The region's unique biodiversity supports the use of various local plants for medicinal purposes, including liquorice. This contextual relevance emphasizes the importance of regional studies in validating the efficacy of traditional remedies in modern health practices.

13) Container:
In the context of this study, 'container' refers to the amber-colored, sequentially numbered vessels used to hold mouth rinse solutions. Proper containment is crucial for maintaining the integrity and stability of herbal formulations, ensuring they remain unaffected by external factors until administration to participants.

14) Medicine:
Medicine encompasses both the science of diagnosing and treating illnesses and the substances used for healing. The study focuses on herbal medicine, emphasizing the potential of liquorice as a viable alternative treatment for managing dental health issues. This highlights the significance of integrating traditional remedies into contemporary therapeutic regimens.

15) Relative:
The term 'relative' can refer to the comparative effectiveness of liquorice and chlorhexidine in reducing dental plaque and gingivitis. Understanding the relative efficacy is essential for choosing appropriate treatments and guiding future research on herbal alternatives in oral care within both clinical and public health contexts.

16) Samhita:
Samhita refers to ancient texts that compile traditional knowledge, especially in Ayurveda. References to texts like Sushruta Samhita in the study underscore the historical usage of herbs like liquorice. This acknowledgment enriches the research by connecting modern studies with traditional wisdom, validating herbal practices and their relevance today.

17) Hygiene (Hygienic):
Hygiene pertains to practices that promote health through the prevention of disease. The study's focus on oral hygiene emphasizes the importance of effective mouth rinses in controlling plaque and preventing gingivitis. This relevance highlights the need for integrating herbal solutions into routine dental care for improved oral health.

18) Mandal:
Mandal refers to an administrative region in India and is relevant in the study's context by identifying the locality of research. This consideration is important for regional studies as it indicates the cultural and agricultural background where medicinal plants like liquorice are sourced and used in traditional practices.

19) Nature:
Nature encompasses the biological and ecological aspects of the environment from which herbal remedies are derived. The study of liquorice roots highlights the importance of utilizing natural resources sustainably. Recognizing nature's contribution to health promotes the integration of herbal medicine within broader ecological and health frameworks.

20) Powder:
Powder refers to the form in which liquorice extract is prepared for use. The preparation process is critical for ensuring effective comprehension and dosages in studies. Understanding the impact of powdered herbal formulations on efficacy and patient compliance is essential for developing practical therapeutic applications in dentistry.

21) Food:
Food relates to substances consumed for nutritional support, but in this context, it also includes herbal ingredients recognized as safe for dietary use. The FDA's classification of liquorice as GRAS (Generally Recognized As Safe) underlines its potential for incorporation into dietary practices, which can bolster acceptance in herbal medicine.

22) Drug:
The term 'drug' pertains to any substance used for therapeutic purposes, including natural products like liquorice. The study explores the effectiveness of liquorice as a mouth rinse, framing it as a potential therapeutic drug alternative for oral health, and examining its broader implications in the pharmacological field.

23) Glycyrrhiza glabra:
Glycyrrhiza glabra is the botanical name for liquorice, the subject of the study. Understanding its scientific classification is crucial for recognizing its medicinal properties. This specificity allows for deeper exploration into its applications and benefits in traditional and modern medicine, fostering further research and potential therapeutic development.

24) Burning sensation:
Burning sensation refers to a common side effect experienced during the use of certain mouth rinses. In the study, participants were monitored for any adverse effects, including this sensation. Understanding such experiences is essential for evaluating the comfort and tolerability of herbal versus chemical treatments, influencing patient compliance.

25) Acacia catechu:
Acacia catechu is another herb noted for its medicinal applications in traditional practices. Mentioning it in the study contextualizes the exploration of various herbal treatments for oral diseases. Comparative references to different herbal remedies enrich the discourse on the effectiveness and safety of natural products in dental health.

26) Ocimum sanctum:
Ocimum sanctum, also known as holy basil or tulsi, is recognized for its therapeutic properties and relevance in traditional medicine. Its mention in the study broadens the context of herbal treatments for oral health by highlighting a range of plants with potential antibacterial properties beneficial for dental hygiene.

27) Human body:
The human body is the biological context in which the study operates. By examining how liquorice and CHX mouth rinses interact with the human body, the research contributes to understanding herbal remedies' safety and effectiveness. This relevance emphasizes the importance of integrating herbal medicine into health practices for humans.

28) Sushruta-samhita (Susruta-samhita):
Sushruta-samhita is an ancient Indian surgical text that outlines traditional medical knowledge. Its mention in this study underscores the historical significance of herbal treatments, including liquorice, and highlights the intersection between ancient practices and contemporary research, validating the ongoing relevance of traditional knowledge in modern healthcare.

29) Punica granatum:
Punica granatum, commonly known as pomegranate, is referenced in discussions about herbal efficacy. Its inclusion signifies the broader exploration of natural ingredients in oral health research. By comparing various herbal constituents, the study aims to establish the benefits and roles of different plants in preventing periodontal diseases.

30) Antibiotic (Antibacterial):
Antibiotic refers to substances used to kill bacteria or inhibit their growth. While the study evaluates liquorice as a natural alternative to traditional antiplaque treatments like chlorhexidine, the understanding of antibiotic properties in herbal remedies can broaden the scope of natural treatments available for infection management and oral health.

31) Announcement:
An announcement signifies the communication of important information, often made to recruit participants for the study. Clear announcements ensure transparency and engagement, facilitating diverse participation. Effective communication of the research's objectives allows for accurate understanding and helps build trust among potential participants in clinical trials.

32) Accumulation (Accumulating, Accumulate):
Accumulation in this context refers to the buildup of dental plaque, which is a primary concern addressed by the study. The focus on reducing accumulation emphasizes the need for effective oral hygiene solutions. Understanding plaque accumulation mechanisms is essential for developing strategies to prevent periodontal disease and enhance oral health.

33) Atharvaveda (Atharva-Veda):
Atharvaveda is one of the ancient Indian texts that includes knowledge on medicinal plants. Its mention in the study connects modern research to traditional practices, demonstrating the historical use of herbs like liquorice in the treatment of ailments. This bridging of ancient wisdom with current studies enhances the credibility of herbal applications.

34) Discussion:
Discussion refers to the analytical section of the study where findings are interpreted. It synthesizes results, compares them with existing literature, and draws conclusions. This part is vital for understanding the implications of the research, exploring future directions, and providing context about how findings contribute to existing knowledge in dental health.

35) Developing:
Developing refers to the context in which the study is conducted, particularly in a country like India that may have limited healthcare resources. Focusing on affordable and accessible treatments, such as herbal mouth rinses, highlights the relevance of integrating traditional medicine into modern healthcare systems in developing regions for better health outcomes.

36) Swallowing:
Swallowing refers to the action of ingesting, which can influence the effectiveness of mouth rinses. The sweet taste of liquorice may encourage faster swallowing, potentially reducing its contact time on oral tissues. Understanding swallowing dynamics is crucial for assessing the efficacy and patient experience when using herbal mouth rinses.

37) Substance:
Substance refers to any material with distinct properties. In this study, substances encompass both herbal extracts and chemical formulations. Understanding the properties and interactions of various substances is crucial for evaluating their efficacy, safety, and suitability for use in treatments within dental and broader medical contexts.

38) Flavonoid:
Flavonoid is a class of bioactive compounds found in many plants known for their health benefits, including anti-inflammatory and antioxidant properties. The study touches on the presence of flavonoids in liquorice, highlighting their role in potentially mitigating dental issues. Understanding flavonoids paves ways for further research into functional foods and natural remedies.

39) Burning (Burn, Burned, Burnt):
Burning, often related to discomfort caused by mouth rinses, is a significant aspect to monitor in clinical trials. Any burning sensation experienced by participants can affect adherence and overall satisfaction with the treatment. Addressing patient-reported outcomes, including burning sensations, is essential for evaluating the clinical relevance of herbal mouth rinses.

40) Allergy:
Allergy refers to adverse reactions triggered by the body's immune response to a substance. Assessing potential allergies to liquorice or other ingredients is crucial for ensuring participant safety in the study. The consideration of allergies helps mitigate risks and enhances the ethical standards of conducting clinical research.

41) Forest:
Forest refers to the natural habitat where various medicinal plants grow, including liquorice. The importance of forests in biodiversity and herbal medicine underscores the potential of sustainably sourced ingredients in research. Encouraging conservation practices supports the utilization of natural resources for health benefits while promoting ecological sustainability.

42) Syria (Syrian):
Syrian refers to the historical context of herbal medicine and its regional applications, including plants used in ancient Syrian practices. Understanding the broader historical significance of herbal treatments connects globally recognized methods to local practices. This context enriches the discussion of herbal efficacy and cultural practices across different civilizations.

43) Reason:
Reason indicates justification or rationale behind the study's objectives and methodologies. In research, clearly stating the reason for investigating liquorice as a mouth rinse helps contextualize its relevance. It directs attention to the importance of exploring alternatives to traditional treatments, particularly in light of known side effects of mainstream medications.

44) Botany:
Botany is the scientific study of plants, encompassing their biology and ecology. This discipline forms the foundation for understanding herbal medicine, including the study of liquorice. Knowledge in botany aids in the identification, cultivation, and sustainable use of plants for medicinal purposes, highlighting its relevance in traditional and modern medicine.

45) Roman (Roma):
Roman indicates historical practices in herbal medicine that inform current understanding and usage of plants. Knowledge from Roman herbal texts and traditions adds depth to the study of liquorice, showcasing how historical practices influence contemporary research and the integration of ancient wisdom into modern therapeutic approaches.

46) Candy:
Candy refers to sweet confections, and the mention in the context of liquorice indicates its usability in alternative forms, such as lozenges or candies. Evaluating the effectiveness of liquorice in various formats emphasizes the importance of patient compliance, particularly for those seeking more palatable options in oral care treatments.

47) Water:
Water is a fundamental solvent in which herbal extracts are often prepared. Its role in dissolving active compounds from plants like liquorice for mouth rinses highlights its importance in formulating effective treatments. Understanding the impact of water quality and quantity on extraction processes is vital for ensuring therapeutic efficacy.

48) Ulcer:
Ulcer refers to a sore that develops on the skin or mucous membranes. Investigating the effects of liquorice in treating oral ulcers highlights its therapeutic potential. Understanding how herbal remedies can alleviate symptoms associated with conditions like ulcers enriches the discussion on their applicability in dental health practices.

49) Visit:
Visit refers to the scheduled appointments participants have during the study for evaluations and data collection. Structured visits are essential to ensure proper monitoring of treatment effects and participant adherence. The methodical approach to visits is crucial for maintaining study integrity and assessing the outcomes effectively.

50) Male:
Male refers to one of the demographics involved in the study's participant pool. Understanding gender differences is relevant in healthcare research as it may influence health outcomes and treatment efficacy. Including diverse genders in studies enhances the representativeness and applicability of findings to the broader population.

Other Science Concepts:

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Discover the significance of concepts within the article: �Liquorice mouth rinse effects on plaque and gingivitis: a trial�. Further sources in the context of Science might help you critically compare this page with similair documents:

Randomized controlled clinical trial, Gingival inflammation, Gingival index, In vitro, Minimum inhibitory concentration, Dental plaque, Periodontal pathogens, Minimum bactericidal concentration, Clinical trial registration, Oral hygiene practice, Cultural acceptability, Natural herbal product, Bioactive ingredient.

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