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Effect of nano-silver membrane on early wound healing post-surgery

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Effect of nano-crystalline silver membrane on early wound healing after periodontal surgery: A comparative randomized study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Kanika Aggarwal, Shipra Gupta, Shaveta Sood, Sonia Bhonchal Bhardwaj, Savita Prashar, Ashish Jain


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Effect of nano-crystalline silver membrane on early wound healing after periodontal surgery: A comparative randomized study

Year: 2021 | Doi: 10.4103/jisp.jisp_17

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study focuses on the use of periodontal dressings following surgical procedures such as flap surgeries for chronic periodontitis. These dressings serve various purposes, including protecting the wound, minimizing pain, and preventing infection. Traditional dressings can lead to plaque accumulation, resulting in inflammation and bacterial growth. This has prompted the exploration of alternative dressings, such as nano-crystalline silver membranes, which have demonstrated antimicrobial properties and the potential to enhance wound healing. The present research aims to evaluate the effectiveness of a nano-crystalline silver dressing compared to a non-eugenol dressing, analyzing both clinical and microbiological parameters post-surgery.

Enhanced Wound Healing with Nano-Crystalline Silver

One significant finding from the study is the superior healing index observed in patients using the nano-crystalline silver dressing compared to those with the conventional non-eugenol dressing. At both the 7th and 14th days post-surgery, the test group displayed a significantly higher healing score, indicating that the silver dressing not only facilitates faster wound recovery but also reduces microbial colonization in the area. The research measured various factors, including the plaque index and levels of vascular endothelial growth factor (VEGF), which also showed significant increases in the test group, suggesting that the silver dressing may promote a more favorable healing environment by enhancing tissue repair processes and reducing inflammation.

Conclusion

In conclusion, the study effectively demonstrates the advantageous role of nano-crystalline silver as a periodontal dressing. It not only decreases microbial load but also fosters improved healing outcomes following periodontal surgery, making it a promising alternative to traditional dressings. These findings underline the potential of incorporating silver nanoparticles into clinical practice to enhance postoperative recovery in periodontal procedures. Future research with larger sample sizes is warranted to further explore and validate these benefits in diverse patient populations.

FAQ section (important questions/answers):

What is the purpose of using periodontal dressings post-surgery?

Periodontal dressings are used to protect surgical wounds, minimize postoperative pain, prevent infection, and support healing by stabilizing flaps or grafts.

How does nano-silver contribute to wound healing in periodontal surgery?

Nano-silver particles promote wound healing through their anti-inflammatory and antimicrobial properties, reducing microbial colonization and enhancing tissue healing after surgery.

What were the main findings regarding the healing index in the study?

The study found that the healing index was significantly higher in the test group using nano-silver dressing compared to the control group at both 7 and 14 days post-surgery.

How did microbial levels change after using the nano-silver dressing?

The use of nano-silver dressing significantly reduced colony-forming units/ml of bacteria in the test group compared to the pre-surgery levels, showing its effectiveness in controlling microbial growth.

What factors were considered in the inclusion criteria for the study?

Patients with chronic periodontitis who were systemically healthy, aged 25 to 60 years, and without allergies to silver or active infections were included in the study.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effect of nano-silver membrane on early wound healing post-surgery�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table in a research context is a structured arrangement of data relevant to the study's outcomes, results, or metrics. Tables concisely present quantitative or qualitative data, allowing for comparison and visualization of findings. In the study referenced, tables were utilized to detail statistics such as healing indices and microbiological counts, facilitating easier interpretation of the results.

2) Silver:
Silver is a metallic element known for its antimicrobial properties, particularly its ability to inhibit bacterial growth. In this study, nano-crystalline silver was employed as a dressing material. This dosage is crucial in enhancing wound healing through its antibacterial action, which reduces the risk of postoperative infections and promotes a quicker recovery.

3) Dressing:
A dressing is a protective covering placed on a wound to promote healing and prevent infection. In periodontal surgery, various types of dressings serve different functions, such as maintaining flap stability, controlling bleeding, and providing comfort. The incorporation of nano-silver into the dressing within this study highlights the innovation in enhancing healing effectiveness while minimizing microbial colonization.

4) Study (Studying):
The study represents systematic research aimed at exploring the efficacy of nano-crystalline silver as an antibacterial dressing in periodontal surgery. It includes controlled experimentation, data collection, analysis, and interpretation of outcomes. The results provide insights into improved clinical methods for managing wound healing and enhancing patient comfort and safety.

5) Surface:
Surface refers to the outer layer or boundary of a tissue or materials utilized in the study, particularly concerning the gingival area. The text discusses how the silver dressing interacts with this surface, influencing microbial attachment and subsequent inflammation, which can impact healing dynamics and patient outcomes in periodontal procedures.

6) Antibiotic (Antibacterial):
Antibacterial properties denote the capability of a substance to inhibit bacterial growth or kill bacteria. In the context of this study, silver's known antibacterial activity is vital for reducing infection risks in surgical wounds, illustrating how advanced materials can enhance periodontal healing by preventing microbial colonization beneath dressing materials.

7) Post:
Post refers to the period after an event, specifically postoperative conditions in this context. Understanding post-operative outcomes such as healing indices and infection rates is crucial for assessing the effectiveness of treatments. Post-surgery evaluations provide data that guide further clinical decisions and inform future research in periodontal care.

8) Bleeding:
Bleeding is a significant concern in surgical procedures, including periodontal surgeries. The ability of a dressing to minimize bleeding contributes to the overall success of the surgery. This study highlights the role of antimicrobial dressings not only in protecting the surgical site but also in reducing the risk of excessive bleeding during recovery.

9) Incision:
An incision is a surgical cut made in the skin or tissue. Proper healing of incisions is critical to prevent complications such as infections and scarring. In periodontal surgeries, controlling the incision healing process through the use of beneficial materials like silver ions can significantly improve patient outcomes and comfort.

10) Disease:
The term disease refers to pathological conditions affecting health, such as chronic periodontitis. Understanding the disease process is fundamental in developing effective treatment strategies, including the application of novel antimicrobial dressings. The study emphasizes the role of silver in combatting disease progression and promoting healthier healing environments post-surgery.

11) Observation:
Observation is a pivotal aspect of research methodologies, enabling the collection of data regarding clinical outcomes or phenomena. In this study, systematic observations regarding healing indices, microbial counts, and inflammatory markers were performed to assess the effectiveness of the silver dressing, thereby contributing to the scientific understanding of periodontal treatment advancements.

12) Species:
In microbiology, species refers to groups of microorganisms characterized by similar traits. The study's examination of bacterial species before and after surgery was essential to understand the impact of the silver dressing on microbial shifts, which in turn affects healing dynamics and the potential for wound reinfection.

13) Rules:
Rules in a scientific context often refer to established guidelines or protocols governing research design and data interpretation. In this study, adherence to ethical rules and methodological rigor ensures the reliability and validity of results, serving as a foundation for evidence-based conclusions regarding silver's efficacy in periodontal applications.

14) Pur:
The term poor highlights suboptimal results or conditions, such as poor healing outcomes related to periodontal procedures. In the context of this study, understanding poor healing metrics is crucial as comparing them against improved outcomes with nano-crystalline silver dressing can elucidate the benefits of advanced materials in enhancing surgical recovery.

15) Inflammation:
Inflammation is a biological response to injury or infection, often associated with redness, swelling, and pain. In periodontal healing, managing inflammation is crucial as excessive inflammation can impede recovery and increase the risk of complications. The study indicates that silver's anti-inflammatory properties help mitigate this response, thereby enhancing healing.

16) Aureus:
Staphylococcus aureus, commonly referred to as aureus, is a type of bacterium that can cause infections, particularly after surgical interventions. Its presence and behavior in the context of wound healing is significant, influencing decisions around treatment strategies aimed at reducing infection risk, as highlighted in the study's microbiological findings.

17) Repair:
Repair refers to the biological processes that restore tissue integrity following injury or surgery. In the context of this study, evaluating the mechanisms promoting repair via silver dressings speaks to broader implications for improving surgical outcomes and patient recovery, emphasizing the importance of innovative materials in tissue regeneration.

18) India:
India serves as the context for the research, providing a geographical and cultural framework for understanding healthcare practices and their implications. The conducted study, approved by local ethics committees, reflects the integration of global scientific advancements in specific regional settings, thus contributing to the body of knowledge in periodontal therapeutic strategies.

19) Kumar:
Kumar likely refers to a researcher or author associated with the study or related literature. Such references are significant for tracing the contributions of various individuals to the field of periodontal research, highlighting the collaborative nature of scientific inquiry and advancing knowledge regarding the utilization of novel treatments in dentistry.

20) Glass:
Glass is mentioned in the context of utilizing sterile glass surfaces for the mixing of materials like eugenol-free pastes for dressings. This attention to sterility and proper handling of materials is critical in dental and surgical procedures to prevent contamination and ensure patient safety during treatment.

21) Accumulation (Accumulating, Accumulate):
Accumulation refers to the build-up of substances, such as dental plaque, which can lead to complications in periodontal health post-surgery. Understanding bacterial accumulation patterns is vital for assessing the effectiveness of dressings in controlling infection and promoting healing, ultimately guiding improved treatment protocols.

22) Discussion:
Discussion sections in research provide the opportunity to interpret findings and relate them to existing knowledge. In this study, the discussion emphasizes the implications of the results regarding silver’s role in wound healing and infection prevention, allowing researchers to contextualize their findings within broader scientific conversations and future research directions.

23) Developing:
Developing refers to the process of growth or evolution, often in the context of treatments or health conditions. In this study, developing an innovative therapeutic approach that incorporates silver nanoparticles is central to addressing periodontal disease and enhancing healing processes, representing an important stride in dental medicine.

24) Toxicity:
Toxicity relates to the degree of harm a substance can cause to biological tissues. In periodontal treatments, understanding the low systemic toxicity profile of silver is crucial, as it informs clinicians about the safety and efficacy of its application, ensuring that patient care is prioritized while minimizing adverse outcomes.

25) Activity:
Activity in a biomedical context can refer to the biological effects or mechanisms of action of a substance. The study investigates the antimicrobial activity of silver in periodontal dressings, aiming to elucidate its effects on wound healing and infection control, thereby advancing our comprehension of materials used in dental surgery.

26) Hygiene (Hygienic):
Hygiene pertains to practices that promote health and prevent disease, particularly important in dental care. This study underscores the importance of maintaining proper hygiene in conjunction with effective surgical materials, as good hygiene practices before and after surgery can enhance the healing process and prevent infections.

27) Allergy:
Allergy refers to an adverse immune response to substances like medications or materials. The study's exclusion criteria for patients with allergies to silver emphasize the importance of patient safety and the need for careful patient selection when implementing new treatment modalities in clinical settings.

28) Science (Scientific):
Science pertains to the systematic study of the natural world through observation and experimentation. The research discussed contributes to the scientific understanding of antimicrobial agents like silver in tissue healing, showcasing how scientific exploration can lead to innovative practices in healthcare and improved patient outcomes.

29) Animal:
Animal studies are often pivotal in biomedical research, helping to illuminate biological responses before human applications. In the context of this study, references to animal studies might underscore the foundational evidence supporting the use of silver in wound healing, motivating its clinical translation into dental practice.

30) Cotton:
Cotton is often utilized in laboratory settings for its absorbent properties and sterility. In the study, cotton swabs were used for sample collection, highlighting the emphasis on cleanliness and appropriate lab techniques to ensure that microbial analyses were accurately performed and reliable results were obtained.

31) Water:
Water is essential for many biological processes, including the activation of silver nanoparticles. The study highlights the significance of utilizing sterile water in activating dressing materials, emphasizing its role in ensuring the efficacy of treatments while preventing the risks associated with contaminating surgical environments.

32) Lata:
Lata may refer to a researcher or contributor involved in the statistical analysis of the study's data. Recognizing individuals who contribute to research enhances transparency and acknowledges the collaborative nature of scientific investigations, which often require diverse expertise to draw valid conclusions from complex datasets.

33) Genu:
Genu, potentially a misspelling or context-specific term, is not explicitly defined within the study context provided. However, in broader scientific discussions, it could refer to anatomical terms relevant to the study's subjects or surgical outcomes, signifying the detailed anatomical considerations necessary in periodontal research and surgery.

34) Sign:
A sign in medical terminology often denotes an observable indication of a condition or outcome. The study examines various signs associated with healing and inflammation in postoperative assessments, allowing researchers and clinicians to draw conclusions about treatment effectiveness and the healing process.

35) Pain:
Pain is a critical symptom often addressed in postoperative care. Understanding pain management strategies is essential for optimizing patient comfort and recovery. The study suggests that improved healing induced by silver dressings may correlate with reduced pain levels, therefore crucially impacting the quality of patient care.

36) Salt (Salty):
Salt can refer to various compounds, including those used in medical applications, such as drug delivery mechanisms. While not explicitly detailed in the study, understanding the role of specific salts in medical treatments or the preparation of dressings could be relevant in tailoring effective therapeutic strategies in periodontal surgery.

37) Drug:
A drug is a substance used for medical purposes, often to treat or prevent disease. Within this study, the focus on drug-loaded dressings signifies the innovative confluence of pharmacology and surgical techniques, addressing how medications can be integrated into wound management strategies to enhance healing.

38) Male:
Male describes the gender of subjects in the study, representing half of the patient population analyzed. Attention to gender-related differences in healing responses or treatment effectiveness may be vital for understanding the broader implications of clinical research and tailoring individualized treatment approaches.

Other Science Concepts:

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Discover the significance of concepts within the article: �Effect of nano-silver membrane on early wound healing post-surgery�. Further sources in the context of Science might help you critically compare this page with similair documents:

Local anesthesia, Plaque index, Surgical Procedure, Vascular endothelial growth factor, Microbiological analysis, Microbial colonization, Colony forming unit, Sterile conditions, Gingival crevicular fluid, Healing Index, Periodontal flap surgery, Periodontal dressing, Peri-implant infection.

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