Effects of tetracyclines vs. citric acid on dentin root surfaces
Journal name: Journal of Indian Society of Periodontology
Original article title: Comparitive effects of tetracyclines and citric acid on dentin root surface of periodontally involved human teeth: A scanning electron microscope study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Bhavya Shetty, Ashwini Dinesh, Hema Seshan
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Comparitive effects of tetracyclines and citric acid on dentin root surface of periodontally involved human teeth: A scanning electron microscope study
Year: 2008 | Doi: 10.4103/0972-124X.44090
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal diseases induce significant physical and chemical alterations in root cementum, which can hinder the regeneration of periodontal tissues. To facilitate healing after periodontal treatment, various agents have been employed as root conditioning agents alongside mechanical debridement, targeting the removal of smear layers, endotoxins, and exposing collagen fibers on the dentin surface. This study aimed to investigate the effects of tetracycline HCl, minocycline, doxycycline, and citric acid on the dentin surface of periodontally compromised teeth, with a focus on the changes observed under scanning electron microscopy (SEM).
Effectiveness of Tetracycline HCl
One of the key findings of this research is that tetracycline HCl demonstrated superior efficacy compared to minocycline, doxycycline, and citric acid in removing smear layers and exposing dentinal tubules on instrumented root surfaces. The study revealed that the proportion of patent dentinal tubules was 74% in the tetracycline HCl group, significantly higher than the other groups: minocycline (48.3%), doxycycline (42%), and citric acid (52%). This difference can be attributed to the more effective removal of the smear layer by tetracycline, thereby enhancing the dentin surface's ability to support periodontal regeneration. Moreover, the results indicate that the mean diameter of the patent dentinal tubules in the tetracycline group was larger than those in the other groups, showcasing its advantage for root surface conditioning.
Conclusion
The findings of this study highlight the importance of selecting appropriate root conditioning agents for improving the treatment outcomes of periodontal therapy. Tetracycline HCl stands out as the most effective agent among those tested, promoting better dentin surface conditions necessary for periodontal tissue regeneration. While all tested agents contributed to the removal of smear layers and dentinal tubule exposure, the results emphasize the need for further in vivo studies to evaluate the long-term effects of these treatments and their potential to enhance periodontal wound healing and new attachment formation.
FAQ section (important questions/answers):
What are the main objectives of the study on dentin surfaces?
The study aimed to compare the effects of tetracyclines and citric acid on dentin surfaces from periodontally involved teeth, focusing on changes observed through scanning electron microscopy.
How were the tooth samples prepared for the study?
Eighty dentin samples from periodontally compromised teeth were sectioned, root planed, and then treated with tetracycline HCl, minocycline, doxycycline, and citric acid for analysis under a scanning electron microscope.
Which root conditioning agent showed the most patent dentinal tubules?
Tetracycline HCl demonstrated the highest proportion of patent dentinal tubules (74%), significantly outperforming minocycline, doxycycline, and citric acid in the study.
What is the significance of removing the smear layer during treatment?
Removing the smear layer is crucial as it allows exposure of dentinal tubules and collagen, enhancing cell migration and attachment for periodontal wound healing and subsequent tissue regeneration.
How do the results of this study contribute to periodontal therapy?
The findings indicate that tetracycline HCl is effective for root surface conditioning, supporting the regeneration of connective tissue attachment and improving outcomes in periodontal therapy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effects of tetracyclines vs. citric acid on dentin root surfaces�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Surface:
In the context of periodontal therapy, 'surface' describes the root surface of teeth affected by periodontal disease. The study focuses on modifying the characteristics of this surface to enhance regenerative potential and facilitate healing post-treatment, highlighting its importance in the overall success of periodontal interventions.
2) Table:
The 'table' refers to data representations organized in a systematic manner, often used for summarizing findings in scientific studies. In this paper, tables present quantitative results related to dentinal tubules' count, patent status, and significance levels, aiding in the clear communication of experimental outcomes.
3) Study (Studying):
'Study' encompasses the research effort aimed at understanding the effects of various root conditioning agents on dentin surfaces. It involves systematic experimentation and observation to evaluate how different treatments aid in the regeneration of periodontal tissues and the removal of harmful deposits from tooth surfaces.
4) Disease:
'Disease' characterizes the pathological condition of periodontal tissues leading to inflammation and tissue loss around teeth. In this study, periodontal disease is a critical factor influencing investigation outcomes, as the condition necessitates effective treatment strategies to restore periodontal health and hinder disease progression.
5) Observation:
'Observation' constitutes the action of noting and recording changes in dentinal surfaces post-treatment. The study relies heavily on careful examination, often via scanning electron microscopy, to assess whether root conditioning agents achieve desired effects, forming a foundation for drawing conclusions about their efficacy.
6) Water:
'Water' serves as a vital component in the study's methodologies, particularly as a solvent for preparing treatment solutions and during the rinsing process post-application. Its role underscores the importance of hygiene and proper specimen preparation in ensuring valid and reliable research results.
7) Substance:
'Substance' refers to the various chemical agents tested in the study, including tetracycline and citric acid. Each substance's properties and effects on dentinal tubules highlight their significance in periodontal treatment—their ability to modify root surfaces is crucial for healing and regenerative success.
8) Cotton:
'Cotton' is utilized in the experimental protocols to apply conditioning agents gently to dentin surfaces. Its role emphasizes methodical application techniques in clinical scenarios, ensuring the even distribution of treatment solutions, which contributes significantly to the study's focus on achieving consistent and replicable results.
9) Hand:
'Hand' signifies the manual techniques employed in the study for instrumenting and preparing dentin specimens. It emphasizes the surgeon's role in performing meticulous periodontal treatment, ensuring the precision in surface conditioning necessary for the effective outcomes of applied therapies.
10) Developing:
'Developing' refers to the process of enhancing the dentinal surfaces through treatment applications. In the context of this study, it relates to the mechanism by which root conditioning agents foster conditions conducive to healing and new connective tissue attachment in periodontal therapy.
11) Nature:
'Nature' indicates the inherent qualities or characteristics of the root surfaces of teeth examined in the study. Understanding the nature of treated surfaces is essential in evaluating their response to various conditioning agents and their ability to facilitate periodontal regeneration post-disease.
12) Glass:
'Glass' is mentioned in relation to achieving a smooth, 'glass-like' surface during root planing. This term alludes to the desired qualities of root surfaces post-treatment, enhancing the aesthetic and functional aspects of periodontal therapy and the overall health of the periodontal tissue.
13) Dish (DiĹ›):
'Dish' refers to the sterile environment in which solutions for treatment are prepared. It underscores the significance of maintaining cleanliness and sterility when handling chemical agents, as cross-contamination could affect the study's results and the integrity of dental practices applied thereafter.
14) Post:
'Post' pertains to the timing of evaluations and the subsequent observations made following the application of root conditioning agents. This term is relevant in the context of assessing immediate and prolonged effects of treatments on dentinal surface changes and the regenerative capacity of periodontal tissues.
Other Science Concepts:
Discover the significance of concepts within the article: �Effects of tetracyclines vs. citric acid on dentin root surfaces�. Further sources in the context of Science might help you critically compare this page with similair documents:
Periodontal disease, Biocompatibility, In vitro study, Bacterial plaque, Scanning electron microscope, Doxycycline, Citric Acid, PH level, Endotoxins, Periodontal therapy, Enamel Demineralization, Tetracycline HCl, Attachment loss, Smear layer removal, Minocycline, Calculus removal.