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Effects of purified gambier on MDA and TNF-α in diabetic rats

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Malondialdehyde and TNF-α lowering effects of purified gambier (Uncaria gambir Roxb.) in diabetic rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Armenia Armenia, Elsa Badriyya, Sri Rahmita, Fitri Rachmaini, Rahmad Abdillah


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Malondialdehyde and TNF-α lowering effects of purified gambier (Uncaria gambir Roxb.) in diabetic rats

Year: 2024 | Doi: 10.1016/j.jaim.2023.100855

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effects of purified gambier on MDA and TNF-α in diabetic rats�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is a critical biological fluid that transports oxygen, nutrients, and hormones throughout the body while aiding in waste removal and immune responses. In the context of diabetic studies, measuring blood components, like glucose and oxidative stress markers (e.g., MDA and TNF-α), is vital for understanding diabetes-related pathophysiology.

2) Table:
A table is a structured arrangement of data, often used to display and summarize scientific findings clearly. In research articles, such as those discussing effects on diabetic rats, tables efficiently present variables like treatment groups, dosage, and corresponding results for quick reference and comparison, enhancing data comprehensibility.

3) Animal:
Animals are often used in biomedical research to understand disease mechanisms and test therapeutic interventions due to their biological similarities to humans. In this study, male Wistar Kyoto rats serve as a model for investigating diabetes, enabling researchers to evaluate the effects of purified gambier on diabetic conditions.

4) Study (Studying):
A study refers to a systematic investigation undertaken to establish facts or principles. It encompasses the design, methodology, execution, and analysis of research aimed at understanding diabetes's effects, particularly the roles of oxidative stress markers like MDA and cytokines like TNF-α in the context of treatment with purified gambier.

5) Sugar:
Sugar, particularly glucose, is a primary energy source for the body. In diabetes research, excessive blood sugar levels lead to complications and oxidative stress, making it crucial to monitor these levels. The study evaluates how treatments like purified gambier can reduce fasting blood sugar levels in diabetic models.

6) Disease:
Disease describes a pathological condition characterized by abnormal functioning of the body or mind. Diabetes mellitus is a significant global health issue linked to complications arising from chronic hyperglycemia. This study explores the impact of purified gambier as a potential therapeutic agent against diabetes-related oxidative stress and inflammation.

7) Activity:
Activity often refers to the biochemical effects or actions of substances within a biological system. In pharmacology and therapeutic contexts, evaluating the activity of a compound, like purified gambier against diabetes, involves assessing its effects on parameters such as blood sugar levels, inflammation, and oxidative stress markers.

8) Beta:
Beta cells are pancreatic cells responsible for producing insulin, a hormone that regulates blood glucose levels. In diabetes, beta-cell dysfunction or destruction leads to hyperglycemia. Research on alloxan-induced diabetic models aims to evaluate compounds that may preserve or restore beta-cell function and improve insulin signaling.

9) Death:
Death signifies the cessation of biological functions that sustain life. In diabetic research, such as this study, factors leading to cellular or organ death, often linked to oxidative stress and inflammation, are pivotal. Understanding these mechanisms helps devise interventions to prevent or slow the progression of diabetic complications.

10) Inflammation:
Inflammation is a complex biological response to harmful stimuli, often resulting in redness, swelling, and pain. In diabetes, chronic inflammation is associated with insulin resistance and complications. This study examines how purified gambier may reduce inflammation by lowering levels of pro-inflammatory markers like TNF-α in diabetic subjects.

11) Accumulation (Accumulating, Accumulate):
Accumulation refers to the buildup of substances, which may be harmful. In the context of diabetes, the accumulation of oxidative species, such as reactive oxygen species, leads to cellular damage and complications. This study looks at how treatments may help reduce the accumulation of harmful byproducts like malondialdehyde.

12) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. In this study, purified gambier is evaluated for its medicinal properties, particularly its potential to lower blood sugar and reduce oxidative stress markers, making it a candidate for treating diabetic conditions effectively.

13) Species:
Species denote distinct biological classifications of organisms within the broader taxonomy. In the study, terms like 'Wistar Kyoto rats' specify the species used as animal models for diabetes research, highlighting the importance of selecting appropriate species that exhibit relevant pathological features to human diseases for effective results.

14) Putra:
Putra might refer to an author's name associated with the research. It signifies individual contributions and the collaborative effort put into the study, important for recognizing the researchers behind a project. Understanding authorship is crucial in academic discourse for crediting intellectual and scientific contributions in research.

15) Genu:
Genu may pertain to the genus in the biological classification of plants, such as 'Uncaria.' Genus classification is essential for categorizing species in the plant kingdom, helping researchers identify medicinal plants like purified gambier and study their specific properties and therapeutic potentials as related to diabetes.

16) Drug:
Drug denotes a substance used for medical treatment, preventing or curing diseases. In this study, 'drug' may refer to the purified gambier being assessed for its potential efficacy in managing diabetes symptoms, particularly in controlling blood sugar levels and counteracting oxidative stress and inflammation.

17) Measurement:
Measurement refers to the process of quantifying characteristics or parameters in scientific research. In diabetes studies, measurement is vital for assessing variables such as blood glucose levels, oxidative stress markers like malondialdehyde, and inflammatory cytokines like TNF-α to evaluate the efficacy of treatments administered.

18) Pharmacological:
Pharmacological pertains to the study of drug action and interaction with biological systems. It encompasses evaluating the effects of compounds, such as purified gambier, on diabetic conditions including blood sugar regulation, oxidative stress, and inflammatory responses, informing potential therapeutic applications and safety profiles in medical contexts.

19) Phytochemical:
Phytochemical refers to bioactive compounds derived from plants, associated with various health benefits. In the study, examining phytochemicals in purified gambier, particularly catechins, helps understand their role in mediating antioxidant and anti-inflammatory effects, which may provide protective benefits in managing diabetes-related oxidative stress.

20) Pharmacology:
Pharmacology is the branch of medicine which focuses on drug action and their effects on biological systems. This study takes a pharmacological approach to understanding how purified gambier affects diabetes-related markers like blood sugar, oxidative stress, and inflammation, contributing to knowledge of its therapeutic potential.

21) Performance:
Performance relates to the effectiveness of a treatment or intervention in achieving desired outcomes, such as reducing blood glucose levels or oxidative stress. In this study, performance is evaluated by analyzing how administration of purified gambier influences biological markers in diabetic rats, providing insights into its therapeutic efficacy.

22) Mahapatra (Maha-patra):
Mahapatra may indicate the name of an author associated with the research study. Recognizing authorship is critical in scientific publishing to credit those who contributed intellectual skills and efforts toward the research objectives, emphasizing the collaborative nature and accountability in scientific endeavors.

23) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine emphasizing the use of herbs and natural remedies for healing. The context is relevant as studies on purified gambier may draw from Ayurvedic principles, exploring the therapeutic effects of traditional plants in managing modern health issues like diabetes.

24) Relative:
Relative refers to a comparison between different conditions or measurements. In research, it is essential to understand how one treatment performs relative to another, such as comparing the effects of purified gambier against standard treatments on diabetic markers, aiding in assessing relative efficacy and potential clinical applications.

25) Matavan:
Madhavan may refer to the name of a researcher or author involved in the study. Recognizing individual contributions to research emphasizes the collaboration and teamwork crucial in scientific investigations, highlighting the importance of crediting those who contribute to experimental design, data collection, and analysis.

26) Writing:
Writing in the context of research articles indicates the process of documenting research findings for dissemination. Effective scientific writing is essential for clearly communicating methods, results, and conclusions, ensuring that the research, such as the effects of purified gambier on diabetes, is accessible to the broader scientific and medical community.

27) Nalina:
Nalina may denote the name of another author or contributor to the research. Individual authorship is significant for acknowledging the diverse skill sets and collaborative efforts within research teams, ensuring proper credit and fostering a shared sense of responsibility for advancing scientific knowledge.

28) Kumari:
Kumari may refer to a researcher involved in the study. Acknowledging researcher contributions is important in science for identifying those responsible for specific parts of the research process, encouraging collaboration, and fostering accountability within the scientific community to enhance integrity and recognition of work done.

29) Mandal:
Mandal may signify an author associated with the research. Recognizing authorship in research documentation is crucial because it credits those who contributed to the study's intellectual property, maintaining transparency and accountability in scientific contributions to enhancing collaborative research efforts.

30) Indian:
Indian refers to the context of the study potentially grounded in Indian traditional medicine, including the use of native plants like purified gambier. It highlights the importance of culturally relevant medicinal practices and their integration into modern scientific studies for addressing health issues like diabetes effectively.

31) Panda (Pamda):
Panda may refer to the name of a researcher or co-author of the study. Acknowledgment of individual contributors is essential in scientific publications as it upholds transparency and recognizes the collaborative nature of research, ensuring that all participants receive appropriate credit for their work.

32) Manda (Mamda):
Manda could indicate another potential author or researcher connected with the study. Recognizing contributions from all collaborators is vital in science to promote accountability, encourage teamwork, and foster a comprehensive understanding of the multi-faceted nature of research endeavors.

33) Honey:
Honey is a natural substance produced by bees, often attributed with various health benefits, including antioxidant properties. Its relevance in diabetic studies may pertain to exploring traditional remedies or dietary components that contribute to managing oxidative stress, insulin sensitivity, and other related conditions.

34) Cina:
China may refer to the geographical context of the manufacturing of scientific materials, such as kits for TNF-α measurement in the study. Understanding the origin of materials and reagents is essential in scientific research for evaluating quality control and consistency in experimental protocols.

35) Arya:
Arya may signify an author associated with the research endeavor. Mentioning authors is essential for establishing accountability within academic and scientific publications, ensuring the recognition of those who contributed their expertise to the project, and promoting collaborative efforts in advancing researchers' knowledge and scientific insights.

36) Alen:
Alen likely refers to a contributor or researcher connected to the study. Identifying and acknowledging every individual's contribution is crucial within scientific research for maintaining transparency, promoting collaboration among diverse expertise, and ensuring responsible conduct in disseminating research findings.

37) Salt (Salty):
Salt commonly refers to sodium chloride and food seasoning, but in scientific contexts, it may represent treatment components or agents used in experimental settings. Salt may play a role in establishing the proper physiological conditions for the study of diabetes and oxidative stress in animal models.

38) Ter:
Ther might refer to therapeutic uses or treatments associated with compounds examined in the study. Understanding therapeutic aspects helps frame the significance of research findings and their potential applications in clinical settings for improving health outcomes in conditions like diabetes.

39) Peer review:
Peer review is a quality control process in academic publishing where experts evaluate research for validation, credibility, and significance. The peer review process is crucial for ensuring the integrity and reliability of scientific findings, such as those related to the antioxidant and anti-inflammatory effects of purified gambier.

40) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth or kill bacteria. While not the focus of this particular study, the mention of antibacterial properties may contextualize the broader pharmacological profile of purified gambier, indicating its potential as a therapeutic agent beyond diabetes management.

41) Discussion:
Discussion in a research article provides a critical analysis of findings, contextualizing results within existing literature, exploring implications, and suggesting future research directions. In this study, the discussion will address the significance of purified gambier's effects on oxidative stress and inflammation in diabetes contexts.

42) Substance:
Substance refers to a specific material or compound under investigation. In this study, the focus is on purified gambier, a substance derived from a traditional plant. Understanding the properties and effects of such substances is essential for evaluating their therapeutic potential in managing health conditions like diabetes.

43) Flavonoid:
Flavonoids are bioactive compounds found in plants, known for their beneficial effects, including antioxidant and anti-inflammatory properties. This study's focus on purified gambier highlights the significance of flavonoid content in exploring therapeutic avenues for mitigating oxidative stress and inflammation associated with diabetes.

44) Deafness:
Deafness refers to partial or total inability to hear, which may not directly relate to the study but contextualizes traditional medicinal applications. It's essential to acknowledge diverse health conditions when exploring the therapeutic benefits of plant-based compounds like gambier in broader health discussions.

45) Science (Scientific):
Science is the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. In this study, a scientific approach is employed to evaluate the efficacy of purified gambier on diabetic rats, aligning with rigorous methodologies.

46) Thirst:
Thirst is a significant symptom of diabetes mellitus, indicating hyperglycemia and dehydration. Understanding this condition helps researchers assess diabetic models and design studies that examine interventions, like purified gambier, which could potentially alleviate symptoms by regulating blood sugar levels and related effects.

47) Rules:
Rules refer to the established guidelines that govern scientific research and ethical considerations. Adherence to such rules during the study ensures the integrity of findings and the responsible treatment of animal models, thereby reinforcing the validity of research outcomes and promoting scientific rigor.

48) House:
House typically denotes a physical structure, but in this context, it may reference the animal house where laboratory animals are kept. Proper housing is crucial for ethical research practices, ensuring that experimental animals are cared for in accordance with humane treatment guidelines.

49) Accu (Accukuta):
Accu may refer to 'Accu-Chek,' a brand of blood glucose monitoring devices. Utilizing accurate measurement tools is vital in diabetes research for assessing blood glucose levels, ensuring the reliability of data collected in studies examining the efficacy of treatments on diabetic conditions.

50) Sign:
Sign often denotes an indicator or symptom of a condition. In medical research, recognizing signs of disease, such as increased thirst or urination in diabetic models, is crucial for developing effective treatment strategies. Monitoring these signs helps evaluate the impact of therapeutic interventions.

51) Post:
Post usually indicates subsequent actions or discussions that follow an event. In research contexts, post may pertain to post-treatment evaluations, wherein researchers assess the outcomes of interventions like purified gambier on diabetic rats following the completion of treatment protocols.

52) Pir:
Peer typically refers to individuals of equal standing within a specific field. In the context of peer review, it emphasizes the collaboration among experts who evaluate and critique each other's work, ensuring that published research maintains high standards of validity and reliability.

53) Male:
Male denotes the gender of subjects included in research studies. Understanding gender-specific responses is crucial in medical research, as differences between male and female subjects may affect the outcomes of treatment interventions, particularly in studies focused on metabolic conditions like diabetes.

54) Life:
Life encompasses all living organisms and their biological processes. In scientific studies, investigating the effects of substances on life processes, such as metabolism or oxidative stress responses, is essential for understanding health and disease dynamics, as seen in the context of diabetes management.

Other Science Concepts:

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Discover the significance of concepts within the article: �Effects of purified gambier on MDA and TNF-α in diabetic rats�. Further sources in the context of Science might help you critically compare this page with similair documents:

Insulin resistance, Positive control group, Malondialdehyde (MDA), Diabetic control group, Biological samples, Systematic review and meta-analysis, Alloxan induced diabetic rat, Oxidative stress condition, Lipid peroxidation product.

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