Mesenchymal stem cells as a platform for research on traditional medicine
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Mesenchymal stem cells as a platform for research on traditional medicine
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Ramesh Bhonde, Avinash Sanap, Kalpana Joshi
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Mesenchymal stem cells as a platform for research on traditional medicine
Year: 2021 | Doi: 10.1016/j.jaim.2021.08.012
Copyright (license): CC BY-NC-ND 4.0
Download the PDF file of the original publication
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Mesenchymal stem cells as a platform for research on traditional medicine�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
A table is a systematic arrangement of data, which in this context refers to the organized presentation of experimental results in the study of how traditional medicines interact with human mesenchymal stem cells (hMSCs). These tables provide concise data, fostering clear comparisons and interpretations of various herbal effects on cell behavior, thus supporting evidence-based conclusions.
2) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing diseases. The article discusses the integration of traditional medicines, like Ayurveda and Traditional Chinese Medicine, into clinical practices, emphasizing the need for modern scientific validation to ensure safety, efficacy, and quality in these alternative treatment modalities.
3) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India that emphasizes holistic healing and the balance of bodily systems using natural remedies. It incorporates concepts such as Dosha and Dhatu, guiding the treatment of ailments and promoting overall wellness. The relevance to hMSCs is highlighted in validating Ayurvedic herbs scientifically for therapeutic potential.
4) Line:
In a scientific context, a 'line' often refers to a lineage of cells, specifically to cell lines used in research. The article implies that using human mesenchymal stem cells (hMSCs) instead of traditional animal or immortalized cell lines can provide more relevant results that are translatable to human health care, enhancing the testing of traditional medicines.
5) Science (Scientific):
Scientific implies a structured, evidence-based approach to study. The article advocates for applying scientific methodologies to evaluate traditional medicines like Ayurveda to better understand their efficacy, safety, and mechanisms of action, thereby providing a framework that supports the integration of traditional practices into contemporary medical practices for wound healing and regenerative therapies.
6) Drug:
In pharmacology, a drug is a substance used to diagnose, cure, treat, or prevent disease. The text relates to drugs derived from traditional medicine that must be validated through scientific scrutiny, allowing for established protocols for their safe and effective utilization in clinical settings, thus bridging ancient wisdom with modern therapeutics.
7) Flavonoid:
Flavonoids are a class of bioactive compounds found in many fruits and vegetables, known for their antioxidant properties and role in health promotion. The discussion includes their potential to enhance the proliferation and differentiation of hMSCs, illustrating how these plant-derived substances can contribute to the therapeutic effects of traditional medicines.
8) Toxicity:
Toxicity refers to the degree to which a substance can harm humans or animals. The article stresses the importance of evaluating the cytotoxic effects of traditional medicines on hMSCs, as it helps to ensure that herbal treatments used in Ayurveda and other traditions do not pose risks to health, thereby safeguarding patient care.
9) Study (Studying):
Studying refers to the process of engaging in learning or research. The article emphasizes the importance of studying the effects and mechanisms of traditional medicines on hMSCs, as this research is critical for validating herbal remedies' roles and integrating them into modern medical practices, thereby enhancing therapeutic applications.
10) Activity:
Activity refers to the physiological effects or biological responses elicited by a substance. The article discusses how the activity of various traditional medicinal herbs on hMSCs can be scientifically assessed to determine their therapeutic potential, thus enabling a better understanding of their roles in promoting health and treating diseases.
11) Kashaya (Kasaya):
Kashaya, a traditional Ayurvedic formulation, typically consists of decoctions made from several herbs. The article highlights its potential role in modulating cellular effects and promoting health by impacting hMSC behavior, showcasing the relevance of traditional knowledge in modern scientific inquiry and regenerative medicine practices.
12) Quality:
Quality refers to the standard of something as measured against other things of a similar kind. In the realm of traditional medicine, evaluating the quality of herbal preparations is essential to ensure their safety and effectiveness, emphasizing the need for rigorous scientific assessment of herbs utilized in Ayurveda in comparison to modern pharmaceuticals.
13) Disease:
Disease is a pathological condition of a bodily part, an organism, or system resulting from various causes. The article addresses traditional medicines' applications in disease treatment, specifically chronic conditions that may not respond well to conventional therapies, urging a scientific validation for these remedies' therapeutic value in clinical contexts.
14) Cancer:
Cancer refers to diseases characterized by uncontrolled cell proliferation. The text suggests that traditional medicines, through their interaction with hMSCs, may possess potential anti-cancer properties. It emphasizes the need for thorough investigation of these herbs to identify their roles in cancer treatment and possible regenerative therapies.
15) Joshi (Josi):
Joshi is the surname of one of the contributing authors, Kalpana Joshi, highlighting individual contributions to the article's research and conceptual development. This acknowledgment underscores collaborative efforts in scientific inquiry and the importance of diverse perspectives in validating traditional practices through modern research frameworks.
16) India:
India is the country of origin for Ayurveda and many traditional medicines, emphasizing its rich history of herbal and holistic treatments. The article discusses integrating traditional knowledge from India into contemporary scientific methodologies, showcasing the nation's essential role in influencing global health paradigms and natural product research for regenerative therapies.
17) Phytochemical:
Phytochemicals are naturally occurring compounds found in plants that contribute to their color, flavor, and disease resistance. They hold health benefits, potentially influencing hMSC behavior. The text suggests that these bioactive compounds from traditional medicines can enhance research on their therapeutic applications and interactions in regenerative medicine and beyond.
18) Animal:
The term 'animal' is commonly associated with research models used to study biological processes. However, the article stresses the importance of human mesenchymal stem cells over animal models for more accurate and relevant results in testing traditional medicines, thus bridging historical practices with contemporary medicine practices, especially in safety assessments.
19) Water:
Water is a vital solvent used in the preparation of many traditional herbal remedies, including those in Ayurveda. The article outlines its role in extracting bioactive components from herbs and highlights the challenge of solubility of certain herbal medicines, which can affect their efficacy when investigated in hMSCs.
20) Rules:
Rules refer to established guidelines or protocols that govern scientific research and practices. The context of the article implies adherence to these rules is necessary to ensure the validity and reliability of results when assessing traditional medicines, ultimately leading to their proper integration into clinical practice via validated pathways.
21) Sah:
Shah is another contributor's surname, representative of collaborative authorship within the research. It highlights the importance of teamwork in advancing knowledge related to traditional medicine practices, validation efforts, and the unification of scientific methodologies to modernize and authenticate Ayurvedic treatments along with their scientific implications.
22) Sign:
In this context, 'sign' refers to indications observed in scientific studies, particularly concerning the effects of traditional medications on hMSCs or disease models. The article emphasizes the significance of these signs in understanding herbal compounds' efficacy, guiding future research directions and therapeutic applications.
23) Ter:
Ther likely refers to a misspelling of 'therapeutic,' indicating the health benefits or treatment outcomes derived from herbal substances. The article focuses on traditional medicines as therapeutic agents and their capacity to provide efficacy in clinical settings through empirical evidence gained from hMSC studies and traditional remedies.
24) Chan:
Chan is likely a reference to one of the authors or researchers contributing to the research article, emphasizing collaborative efforts in integrating traditional medicines with scientific approaches. This underscores the significance of interdisciplinary collaboration in validating and understanding the potential of Ayurvedic practices within modern medical research.
25) Tinospora cordifolia:
Tinospora cordifolia, known as 'Giloy,' is a significant herb used in Ayurveda for its medicinal properties, including immune-boosting effects. The article highlights its use in studies on hMSCs, demonstrating how herbal compounds can influence cellular behavior and contribute to therapeutic applications in regenerative medicine.
26) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as licorice, is a widely recognized herb in traditional medicine with anti-inflammatory and antioxidant properties. The article discusses its potential effects on hMSCs, suggesting its role in enhancing cell proliferation and differentiation, thus providing a basis for integrating this herb into therapeutic practices.
27) Withania somnifera:
Withania somnifera, or ashwagandha, is an important herb in Ayurvedic medicine known for its adaptogenic and stress-reducing properties. The article evaluates its role in promoting hMSC proliferation and differentiation, paving the way for traditional treatments to align with modern scientific validation in regenerative therapies and health improvement.
28) Curcuma longa:
Curcuma longa, commonly known as turmeric, is recognized for its active compound curcumin, which possesses anti-inflammatory and antioxidant properties. The article explores its effects on hMSCs, demonstrating its potential to enhance cellular functions and support traditional medicine's integration into holistic health practices and clinical applications.
29) Piper longum:
Piper longum, known for its medicinal qualities, is often used in Ayurveda to promote respiratory health and digestion. Its relevance in the study emphasizes its potential effects on hMSCs, encouraging research on how this herbal remedy can enhance therapeutic outcomes when incorporated into modern medical frameworks.
30) Knowledge:
Knowledge refers to the information and understanding derived from research, particularly in integrating traditional medicine with modern science. The article underscores the importance of accumulating knowledge through rigorous studies to validate Ayurvedic practices, ensuring that traditional remedies are effective, safe, and applicable in contemporary health care systems.
31) Writing:
Writing is the process of documenting research findings and ideas. It is fundamental for communicating scientific knowledge and advancing understanding in medicine. The article’s authors emphasize the importance of clear writing in disseminating results that validate traditional medicine, fostering a dialogue between ancient practices and current scientific evidence.
32) Repair:
Repair in the context of this article refers to the regenerative capabilities of hMSCs, which can differentiate into various cell types that aid in tissue regeneration and healing. The significance lies in harnessing traditional medicines that may enhance these repair mechanisms, thus bridging ayurvedic concepts with modern regenerative medicine.
33) Patil:
Patil is likely another contributor to the research, underscoring the collaborative nature of scientific endeavors. The inclusion of multiple perspectives enriches discussions surrounding traditional medicine practices and their scientific validation, further promoting the acceptance of integrative health strategies in modern medical sciences.
34) Developing:
Developing refers to the process of creating or improving something. In the context of the article, it describes the ongoing research efforts to better understand and validate the efficacy of traditional medicines, highlighting the need for innovative approaches to integrate these practices into modern healthcare systems effectively.
35) Harvesting (Harvest):
Harvesting refers to the collection and extraction of bioactive compounds from plants. The article discusses the importance of harvesting strategies for traditional medicinal plants, emphasizing that proper techniques can maximize the health benefits of these herbs when tested on hMSCs, ultimately contributing to their therapeutic applications.
36) Liquorice (Licorice):
Licorice, scientifically known as Glycyrrhiza glabra, is a well-known herb in traditional medicine with many health benefits. The article explores licorice's potential effects on hMSCs, demonstrating how it can enhance treatment strategies in modern medicine while validating its historical use in herbal remedies for various ailments.
37) Species:
Species refer to the basic unit of biological classification and a group of organisms capable of interbreeding. The article touches upon various plant species used in traditional medicine, such as those investigated for their effects on hMSCs, opening avenues for understanding the specific contributions of each plant to health treatments.
38) Sandra (Samdra):
Sandra most likely references one of the authors of the study, pointing to individual contributions to the article. This signifies the collaborative nature of scientific inquiry, where diverse expertise helps bridge traditional knowledge and modern practices, especially in the validation of herbal medicinal therapies.
39) Indian:
Indian pertains to the cultural, historical, and medicinal practices originating from India, particularly Ayurveda. The article emphasizes India's contribution to traditional medicine and the need for scientific validation to integrate these practices into modern health systems effectively, highlighting its rich biodiversity as a source of medicinal herbs.
40) Harita:
Harida generally refers to 'Haritaki,' a well-known medicinal plant in traditional Indian medicine, which has various health benefits. The mention here contextually relates to the exploration of traditional herbal remedies and their validation through modern scientific research, implicating their role in health promoting activities and therapies.
41) Mitra:
Mitra here may refer to one of the authors or researchers contributing to the article's findings. This indicates the collaborative nature of research in traditional medicine studies, which relies on collective expertise to validate and modernize ancient medicinal practices through scientific inquiry.
42) Nayak:
Nayak is likely a reference to one of the contributing authors, emphasizing the teamwork involved in scientific research. It highlights the collaborative effort necessary for advancing the understanding of traditional medicines, aiding in bridging the gaps between ancient practices and modern medical applications through validated research efforts.
43) Doubt:
Doubt implies uncertainty or lack of conviction about certain beliefs or findings. In the context of the article, it suggests an ongoing need for rigorous scientific validation of traditional medicine practices to alleviate skepticism associated with their efficacy and safety, promoting trustworthy integration into modern healthcare paradigms.
44) Blood:
Blood is essential for transporting oxygen and nutrients throughout the body, as well as for immune responses. The article emphasizes utilizing human mesenchymal stem cells in research, which may involve various blood-related applications, including potential therapies for diseases affecting hematological functions through traditional medicine inquiries.
45) Cina:
China represents the origin of Traditional Chinese Medicine, a counterpart to Ayurveda that also utilizes herbal remedies and holistic practices for health. The article compares these traditional systems, underscoring the need for a scientific grounding to validate ancient practices, facilitating their acceptance in global healthcare practices alongside modern approaches.
46) Utta:
Utta is likely one of the contributing authors, representing a collective effort in the research project. The emphasis on authorship reflects the interdisciplinary collaboration necessary in studies bridging traditional and modern medicine, showcasing the importance of collaborative perspectives in making advancements in health-related research fields.
47) Shila (Sila):
Sila potentially refers to a contributor to the research, underscoring collaborative efforts. It illustrates the communal aspect of scientific inquiry, where diverse backgrounds help achieve comprehensive knowledge on integrating traditional medicinal practices with contemporary therapeutic strategies, emphasizing the value of teamwork in research advancements.
48) Aran:
Aran could refer to one of the authors or researchers involved in the article, demonstrating the significance of collaboration within the scientific community. Highlighting contributions from various individuals signifies the necessary teamwork in validating traditional medicines and advancing understanding in integrative health practices across various disciplines.
49) Pune:
Pune is a city in India known for its educational institutions and research centers. Reference to Pune in the article underscores the location's importance in academic discourse surrounding traditional and modern medical practices, emphasizing the convergence of historical knowledge and contemporary scientific inquiry within the Indian subcontinent.
50) Food:
Food encompasses various substances that provide nutritional support to organisms. The article emphasizes evaluating the dietary components of traditional medicines and their potential health benefits, suggesting that some herbs used in culinary practices may also have therapeutic properties, reinforcing the link between nutrition and medicinal practices in health care.
51) Jang:
Jang likely refers to one of the contributors to the research article, indicating the collaborative nature of scientific work. Acknowledging diverse authors emphasizes the importance of teamwork in exploring and validating traditional medicine practices, allowing multiple perspectives to inform health knowledge and therapeutic strategies.
52) Post:
Post refers to something occurring after a certain event. In scientific writing, it may relate to post-experimental analysis or results interpretation. The context suggests evaluating outcomes after employing hMSCs in therapeutic applications pertaining to traditional medicines, emphasizing a rigorous approach to assessing the efficacy of herbal compounds in scientific studies.
53) Sho (So):
Shao likely designates one of the authors, indicative of the collaborative nature of research. Including multiple authors highlights the interdisciplinary effort essential for validating traditional medicines, ensuring comprehensive insights are captured in studies aimed at integrating old practices into modern medical frameworks and practices through scientific validation.
54) Life:
Life refers to the condition distinguishing animals and plants from inanimate matter, characterized by growth, reproduction, functional activity, and continual change. The article relates to stem cell research, aiming to understand how traditional medicines can influence life processes at the cellular level, particularly concerning regenerative medicine and health improvement strategies.
55) Peer review:
Peer review is a process where experts evaluate a manuscript before publication to ensure its validity, significance, and originality. The article mentions peer review to exemplify rigorous scientific methodology, highlighting that studies on traditional medicine undergo critical assessment to validate their findings and promote integrative practices in healthcare delivery.
56) New Delhi:
New Delhi is the capital of India and a prominent center for research and education. Referencing New Delhi emphasizes its role in fostering scientific inquiry and advancement in traditional medicine, highlighting the intersection of ancient knowledge systems with contemporary scientific research being conducted in significant Indian academic institutions.
57) Terminalia bellirica:
Terminalia bellirica, also known as Baheda, is an important herb in Ayurveda recognized for its numerous health benefits. The article emphasizes its relevance in studying the effects of traditional medicines, suggesting potential therapeutic implications when assessed within the framework of hMSC research, thereby enhancing the validation of Ayurvedic practices.
58) Civilization:
Civilization refers to an advanced stage of human social development marked by the practice of agriculture, the establishment of cities, and advanced cultural practices. The article contextualizes Ayurvedic practices as part of early civilizations, underscoring the need to bridge the historical context of medicine with modern scientific validation.
59) Transformation (Transform, Transforming):
Transformed indicates a change in form or structure. In the context of the article, it relates to the transforming effects of certain traditional herbs on hMSC activity, underscoring how phytochemicals can modulate cellular functions and behaviors, thereby integrating traditional medicinal knowledge with scientific insights into structure-function relationships.
60) Anti-aging:
Anti-aging refers to efforts to slow down the aging process, often through the use of medicine or other therapies. The article discusses traditional herbs known for their anti-aging properties, specifically relating to hMSCs and how these remedies can improve cellular senescence, enhancing their longevity and therapeutic effectiveness in regenerative medicine.
61) Substance:
A substance refers to a particular kind of matter with uniform properties. The article focuses on herbal substances and phytochemicals derived from traditional medicines, assessing their potential effects on hMSCs, indicating their importance as therapeutic agents and laying the groundwork for evidence-based applications in healthcare.
62) Rasayana (Rasa-ayana):
Rasayana refers to a category of Ayurvedic herbs and treatments aimed at rejuvenation and promoting longevity. The article highlights how Rasayana therapies can enhance stem cell functions, suggesting their importance in evidence-based approaches to traditional medicine that offer potential health benefits and support regenerative medicine initiatives.
63) Relative:
Relative often refers to the concept of comparing or relating something to another entity. In the article, it can imply the necessity of comparative studies within traditional medicine frameworks against contemporary scientific findings to ensure the relevance and effectiveness of treatments derived from historical knowledge systems in modern healthcare.
64) Kalpana:
Kalpana is likely a reference to one of the authors of the article, acknowledging their contribution to the research. This reflects the collaborative nature of scientific inquiry, demonstrating the importance of diverse perspectives in exploring the efficacy of traditional medicinal practices and their potential integration into contemporary healthcare frameworks.
65) Mineral:
Minerals are naturally occurring inorganic substances that are vital for various physiological processes. The article focuses on the role of medicinal herbs containing minerals that may support the health and functioning of hMSCs, suggesting how traditional practices can incorporate mineral-rich plants for enhanced therapeutic effects and cellular benefits.
66) Surface:
Surface refers to the outermost layer of something. In a cellular context, it is particularly relevant in studying the surface markers of hMSCs that dictate their behavior and potential for use in therapeutic applications. The article relates to how understanding these markers can aid in validating traditional medicines scientifically.
67) Nature:
Nature refers to the inherent qualities of the physical world and its phenomena. The article discusses leveraging natural substances obtained from traditional medicines to influence hMSC behavior, emphasizing the importance of understanding nature’s offerings in developing effective therapeutic strategies that resonate with both traditional and modern medical ideology.
68) Dosha (Dosa):
Dosha is a key concept in Ayurveda representing specific energies believed to govern physiological functions. The article connects Dosha to the therapeutic application of traditional herbs, underscoring its relevance in balancing health and exploring how traditional knowledge informs modern approaches toward integrating Ayurvedic practices into healthcare frameworks.
69) Pitta:
Pitta is one of the three doshas in Ayurveda, associated with metabolism, transformation, and energy production. The article may reference Pitta to contextualize how traditional herbal formulations can be targeted to balance bodily functions, highlighting the connection of Ayurvedic principles to modern medicinal practices and the potential for scientific validation.
70) Kapha:
Kapha is another dosha in Ayurveda related to structure, growth, and lubrication. The article implies the role of Kapha in understanding individual constitutions within traditional medicine, suggesting a nuanced approach to using herbal treatments based on dosha imbalances, thus integrating holistic healthcare principles with empirical evidence from modern research.
71) Asava (Ashava):
Asava refers to fermented herbal preparations in Ayurveda taken for their therapeutic properties. The article emphasizes the significance of studying such formulations to validate their health benefits scientifically and draw connections between traditional practices and their potential applications in contemporary medicinal contexts, particularly related to hMSCs and regenerative medicine.
72) Dhatu:
Dhatu refers to the seven bodily tissues in Ayurveda, pivotal for understanding health and disease. The article links Dhatu nourishment to the efficacy of traditional medicines, advocating for scientific exploration of herbal remedies to understand their effects on these fundamental biological systems and their relevance in promoting health.
73) Delhi:
Delhi, as the capital of India, serves as a central hub for research and healthcare innovation. The mention of Delhi in the article underscores its significance in facilitating the integration of traditional medicine practices like Ayurveda into mainstream scientific discourse, fostering advancements in health and therapeutics across diverse populations.
74) Glass:
Glass can refer to laboratory equipment used in biological research, including cell culture dishes or instruments crucial in hMSC studies. The importance of glassware is generally implied in the context of maintaining sterile environments and proper experimental conditions while illustrating the modern tools used in the exploration of traditional medicine applications.
75) Field:
Field typically denotes a specific area of study or practice. In this context, it refers to the field of regenerative medicine, wherein hMSCs are employed to explore the effects of traditional therapies. The article emphasizes the interdisciplinary nature of this research, bridging traditional knowledge with scientific methodologies in biomedical applications.
[Note: The above list is limited to 75. Total glossary definitions available: 82]
Other Science Concepts:
Discover the significance of concepts within the article: �Mesenchymal stem cells as a platform for research on traditional medicine�. Further sources in the context of Science might help you critically compare this page with similair documents:
Ayurveda, Traditional medicine, Traditional Chinese medicine, Regenerative medicine, Mode of action, Standardization, Traditional Knowledge System, Scientific evidence, Ayurvedic compound, Cell proliferation, Bioactive compound, Cytotoxicity screening, Tissue homeostasis, Plant derived chemicals, Ethical issue, Translational research, Regenerative potential, Human mesenchymal stem cells, Senescence, Differentiation potential.