Repeated dose oral toxicity of Trivanga Bhasma in Swiss albino mice
Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Repeated dose oral toxicity of Trivanga Bhasma in Swiss albino mice
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.
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Pallavi S. Jamadagni
Shrirang B. Jamadagni
Rajendrakumar Singh
Sudesh N. Gaidhani
Sachchidanand Upadhyay
Jayram Hazra
AYU (Journal of Research in Ayurveda):
(An International Quarterly Journal of Research in Ayurveda)
Full text available for: Repeated dose oral toxicity of Trivanga Bhasma in Swiss albino mice
Year: 2013 | Doi: 10.4103/0974-8520.115449
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Trivanga Bhasma, a metallic preparation containing Bhasmas of Naga (lead), Vanga (tin) and Yashada (zinc), was studied for repeated dose toxicity in Swiss albino mice to estimate No Observed Effect Level (NOEL) or No Observed Adverse Effect Level (NOAEL). A total of 80 Swiss albino mice of either sex with an average body weight of 28-30 g were equally divided into four groups (Group I, II, III, and IV). Group I served as control and was given vehicle (honey: water in 2:3 ratio) Group II, III, and IV received Trivanga Bhasma @ 7.8, 39.5,and 78 mg/kg body weight for 90 consecutive days. The effect of drug was assessed on body weight, feed and water consumption changes, hematological, and histopathological parameters. At the end of the study, all animals were sacrificed and examined for gross pathological changes. Histopathological evaluation was performed for control and high dose group. Trivanga Bhasma was found to be safe. No significant clinical signs were noted in all groups studied. No major alterations were observed during histopathological evaluation. Hence, dose rate of 78 mg/kg body weight was established as NOAEL. It is suggested to carry out a toxicity study at possible higher doses and in a different species so as to establish target organ of toxicity.
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Toxicity studies, Trivanga bhasma, Ayurvedic Drug, Chronic toxicity study, Institutional animal ethics committee, Swiss albino mice, Heavy metal, Body weight change, Toxicity study, Therapeutic dose, No Observed Adverse Effect Level, Long-term toxicity studies, Biological system, Differential Leukocyte Count, Gross pathological examination, Histopathological evaluation, Experimental protocol, Clinical sign.