Baliospermum montanum extracts protect against paracetamol hepatotoxicity.
Journal name: Ancient Science of Life
Original article title: Protective effect of extracts of Baliospermum montanum (Willd.) Muell.-Arg. against paracetamol-induced hepatotoxicity-an in vivo and in vitro study
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S. V. Suresh Kumar, S. H. Mishra
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Protective effect of extracts of Baliospermum montanum (Willd.) Muell.-Arg. against paracetamol-induced hepatotoxicity-an in vivo and in vitro study
Year: 2014
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Baliospermum montanum, commonly known as Danthi, is a herbaceous plant from the Euphorbiaceae family, recognized in Ayurveda for its medicinal properties, particularly its potential therapeutic effects on liver-related disorders. The roots of this plant possess various pharmacological benefits, such as being purgative, anthelmintic, and diuretic, making them valuable in treating ailments like jaundice and liver damage. In the study, the hepatoprotective effects of ethyl methyl ketone (EMK) and methanol (MF) sub-fractions derived from the total methanol extract (ME) of B. montanum were evaluated using paracetamol-induced hepatotoxicity models, both in vivo and in vitro.
Protective Effects Against Paracetamol-Induced Hepatotoxicity
The experimental findings highlighted that the methanol sub-fraction (MFMFME) significantly prevented liver damage in rats induced by paracetamol, as evidenced by the restoration of altered biochemical parameters such as serum levels of GOT, GPT, total protein, and albumin. The study demonstrated that doses of 150 mg/kg of MFMFME effectively reduced elevated enzyme levels, comparable to the standard hepatoprotective drug, silymarin. Hepatic tissue examinations also revealed that MFMFME preserved liver architecture and reduced necrosis, confirming its protective properties. Additionally, the in vitro studies displayed that both sub-fractions improved hepatocyte viability and mitigated the toxic effects of paracetamol, signifying their potential role in hepatoprotection.
Conclusion
The research underscores the therapeutic potential of Baliospermum montanum as a natural hepatoprotective agent, supporting traditional Ayurvedic claims regarding its efficacy in managing liver disorders. Both the EMK and MF of the plant exhibited promising results in counteracting paracetamol-induced toxicity in liver cells, showcasing their bioactive components that could play a crucial role in hepatic health. The findings encourage further investigation into isolating the active compounds responsible for these protective effects, thereby enhancing the understanding and application of B. montanum in modern pharmacotherapy for liver-related ailments.
FAQ section (important questions/answers):
What is the aim of the study on Baliospermum montanum?
The study aimed to evaluate the hepatoprotective effect of ethyl methyl ketone and methanol sub-fractions of Baliospermum montanum against paracetamol-induced toxicity in both in vivo and in vitro models.
How was hepatoprotective activity assessed in the study?
Hepatoprotective activity was assessed by measuring serum levels of liver enzymes and conducting histopathological examinations of liver sections in rats treated with paracetamol and the extracts.
What significant results were found regarding the extracts' efficacy?
The methanol sub-fraction showed protective effects by restoring liver enzyme levels and histological structure, comparable to the standard hepatoprotective drug silymarin, indicating its potential therapeutic use.
What conclusion does the study draw about Baliospermum montanum?
The study concludes that Baliospermum montanum possesses significant hepatoprotective properties, supporting traditional claims in Ayurveda for its use in treating liver disorders.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淏aliospermum montanum extracts protect against paracetamol hepatotoxicity.鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of pharmacognosy and phytochemistry, 'activity' refers to the effects or responses observed when testing a substance, particularly its therapeutic effects. Here, it indicates the evaluation of hepatoprotective properties of extracts from Baliospermum montanum against liver damage inflicted by paracetamol, highlighting the efficacy of the tested compounds.
2) Flavonoid:
'Flavonoid' describes a class of polyphenolic compounds found in many plants, recognized for their antioxidant properties. They contribute to many health benefits, including anti-inflammatory and hepatoprotective effects. This study suggests that flavonoids in the extracts from Baliospermum montanum may play a crucial role in sustaining liver function and reducing toxicity.
3) Toxicity:
The term 'toxicity' refers to the degree to which a substance can cause harm to an organism. In this study, paracetamol is used as a hepatotoxin to induce liver damage in test subjects. Understanding toxicity helps evaluate the protective effects of the plant extracts against potential liver injury.
4) Substance:
'Substance' is a broad term encompassing any material, chemical, or compound being investigated for its properties. In this study, it refers to the extracts and fractions derived from Baliospermum montanum, which were tested for their hepatoprotective activity against paracetamol-induced toxicity in vivo and in vitro.
5) Mishra (Misra):
'Mishra' refers to S. H. Mishra, one of the authors of the study. The inclusion of authors' names is vital for attributing research contributions. Mishra's involvement signifies collaboration in exploring the medicinal properties of Baliospermum montanum, emphasizing the academic effort behind the findings presented.
6) Ayurveda (Ayus-veda):
'Ayurveda' is a traditional Indian system of medicine that emphasizes natural healing and the use of herbs for treating ailments. This study invokes Ayurvedic claims regarding the benefits of Baliospermum montanum in liver disorders, thereby connecting traditional knowledge with contemporary scientific research on herbal remedies.
7) Water:
'Water' as a term serves as a fundamental element in biological and biochemical processes. In pharmacological studies, the solvent in which substances are diluted and administered, like the vehicle for in vivo tests, is crucial in determining the efficacy of the extracts being tested against liver toxicity.
8) Blood:
'Blood' refers to the vital fluid in organisms that carries nutrients and waste, indicative in liver function assessments through serum analysis. The study measures various biomarker levels in blood to evaluate liver damage and concurrent healing effects post-extraction treatment, demonstrating the physiological connection between liver health and bloodstream markers.
9) Drug:
'Drug' pertains to any substance used for medicinal purposes. In this study, silymarin is identified as a standard hepatoprotective drug for comparative analysis with the plant extracts, showcasing the relevance of existing treatments when assessing new herbal medicines for potential liver protection.
10) Inflammation:
'Inflammation' is a biological response to harmful stimuli or injury, often underlying many liver diseases. The study highlights the importance of investigating hepatoprotective properties of plant extracts in managing inflammation due to paracetamol-induced liver damage, offering insights towards therapeutic approaches in combating liver inflammation.
11) Discussion:
'Discussion' in scientific literature refers to the section where researchers interpret findings, compare results to existing knowledge, and propose new hypotheses. This section is vital as it enriches the understanding of Baliospermum montanum's effects, contextualizing findings within broader pharmacological research while also drawing potential conclusions and implications for future studies.
12) Science (Scientific):
'Science' encompasses systematic studies aimed at understanding nature through observation and experimentation. This research integrates traditional medicinal knowledge with scientific inquiry to validate the hepatoprotective claims of Baliospermum montanum, thus bridging the gap between empirical evidence and historical herbal uses in health management.
13) Vaidya:
'Vaidya' refers to a practitioner of Ayurveda, emphasizing expertise in herbal medicine. The mention aligns the research with traditional perspectives on health and healing. The role of Vaidya strengthens the cultural and theoretical basis underlying the use of Baliospermum montanum in liver disorder treatments as claimed in Ayurvedic practices.
14) Cancer:
'Cancer' refers to a range of diseases involving abnormal cell growth. The study mentions potential applications of Baliospermum montanum against various diseases, including cancer, positioning its extracts as noteworthy candidates for developing natural treatments, hence calling attention to the broader implications of hepatoprotection in oncological health.
15) Repair:
'Repair' denotes the biological processes through which tissues recover from damage. The study illustrates how the extracts from Baliospermum montanum can assist in restoring liver function and integrity following paracetamol-induced injury, underscoring the need for therapeutic agents that promote tissue regeneration and recovery in liver diseases.
16) Shala (Sala):
'Sala' refers to the Arya Vaidya Sala, a renowned institution for traditional medicine in India. The mention of Arya Vaidya Sala connects the research to a respected source of Ayurvedic knowledge and herbal medicine, indicating the authenticity and tradition behind the medicinal use of Baliospermum montanum.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Baliospermum montanum extracts protect against paracetamol hepatotoxicity.鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Acute Toxicity Studies, Dimethyl sulfoxide, Hepatoprotective activity, Lipid peroxidation, Histopathological examination, Alkaline phosphatase, Albumin, Total protein, Silymarin, Paracetamol induced hepatotoxicity, Total bilirubin, Biochemical parameter, Serum level, Trypan blue exclusion method, Wistar albino rat, Glutamic oxaloacetic transaminase, Percentage viability.