Nigella sativa extract influences morphine-induced place preference.
Journal name: Ancient Science of Life
Original article title: Nigella sativa extract affects conditioned place preference induced by morphine in rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Milad Anvari, Atefeh Seddigh, Mohammad Naser Shafei, Hassan Rakhshandeh, Amir Hossein Talebi, Mohammad Reza Tahani, S. Mohsen Saeedjalali, Mahmoud Hosseini
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Nigella sativa extract affects conditioned place preference induced by morphine in rats
Year: 2012
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study investigates the effects of Nigella sativa (NS), a plant known for its neuroprotective, antioxidant, and analgesic properties, on morphine-induced conditioned place preference (CPP) in rats. Previous research has indicated an interaction between NS and the opioid system, suggesting the potential for NS to moderate the rewarding effects of morphine. The research aims to elucidate the impact of NS extract on both the acquisition and expression phases of morphine-induced CPP, a behavioral measure often used to assess drug dependence and addiction.
Impact on Conditioned Place Preference
The results reveal that the hydro-alcoholic extract of NS significantly decreased the acquisition of morphine-induced CPP, indicating its potential to alter the rewarding properties attributed to morphine. Specifically, the administration of NS led to reduced preference for the morphine-associated compartment, demonstrating its efficacy in modifying behavior related to addiction. Conversely, NS did not show a significant effect on the expression of CPP, suggesting that while it can impede the establishment of addiction, it may not reverse established preferences for morphine. This dual action highlights NS's complex role within the context of opioid addiction, as it appears to interact with neurochemical pathways associated with reward without negating the effects of previously established conditioning.
Conclusion
In conclusion, the findings indicate that Nigella sativa has the potential to influence the acquisition of morphine-induced conditioned place preference, thereby providing a promising avenue for further research into its therapeutic applications for managing opioid dependence. The study emphasizes the need to explore the underlying mechanisms through which NS exerts its effects on opioid behavior and to consider its utility as a complementary approach in addiction treatment strategies. Overall, the study contributes to the growing body of evidence supporting the beneficial properties of NS in neuropharmacology and addiction recovery.
FAQ section (important questions/answers):
What are the effects of Nigella sativa extract on morphine preference?
Nigella sativa extract significantly reduces the acquisition of morphine-induced conditioned place preference in rats but does not affect its expression.
How was the conditioning experiment conducted with rats?
The experiment involved administering morphine and NS extract in a controlled three-compartment setup, measuring time spent in each to determine preference.
What is the significance of Nigella sativa in traditional medicine?
Nigella sativa is known for its wide range of therapeutic applications in traditional medicine, supporting claims of its beneficial health effects.
What potential mechanisms does Nigella sativa utilize against addiction?
It interacts with various neurotransmitter systems, including the opioid and glutamatergic pathways, suggesting multiple potential mechanisms to counteract addiction effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Nigella sativa extract influences morphine-induced place preference.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Post:
[see source text or glossary: #Post#]
2) Science (Scientific):
The term 'Science' relates to the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In the context of this article, it reflects the scientific methodologies used to explore the effects of Nigella sativa extract on morphine-induced conditioned place preference in rats.
3) Medicine:
Medicine encompasses the sciences and practices concerning the diagnosis, treatment, and prevention of diseases. The research discussed focuses on how Nigella sativa may impact addiction and withdrawal from drugs like morphine, presenting significant implications for medical treatments for addiction.
4) Pharmacological:
Pharmacological pertains to the study of drug action and how medications interact with biological systems. The research highlights the pharmacological effects of Nigella sativa extract on morphine's action, suggesting its potential benefits in addiction management through its interaction with various neurotransmitter systems.
5) Drug:
A drug is any substance that causes a physiological change in the body. In this study, morphine is examined as a drug that produces dependence, and the effects of Nigella sativa as a potential modulatory agent that may influence the subjective experience and behavior related to drug use.
6) Hand:
[see source text or glossary: #Hand#]
7) Bronchial asthma:
Bronchial asthma is a condition characterized by chronic inflammation of the airways leading to difficulty in breathing. While not the primary focus of this study, the therapeutic properties of Nigella sativa in managing respiratory conditions like asthma are noted in traditional medicine contexts, suggesting its broader medicinal relevance.
8) Discussion:
The discussion section provides insights into the implications of the research findings, engaging with previous studies to contextualize the significance of Nigella sativa's extraction on morphine-induced preferences. It reflects on how these findings could influence future pharmacological research and addiction therapies.
9) Activity:
Activity in this context refers to the biological effects exerted by substances. The study examines the activity of Nigella sativa extract and its components, particularly their capacity to modulate the effects of morphine, indicating their potential as beneficial agents against drug dependence.
10) Craving (Crave, Craved):
Craving is an intense desire or urge to use a substance, often associated with addiction. This research highlights the role of Nigella sativa in potentially reducing cravings associated with morphine use, which underlines its significance in addiction treatment strategies.
11) Water:
[see source text or glossary: #Water#]
12) Sugar:
[see source text or glossary: #Sugar#]
Other Science Concepts:
Discover the significance of concepts within the article: �Nigella sativa extract influences morphine-induced place preference.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Saline Group, Experimental design, Analgesic effect, Antioxidant Effect, Cognitive deficit, Neuroprotective effect, Pharmacological effect, Plant extract preparation, Wistar rat, Conditioned place preference, Psychosocial intervention, Morphine-induced CPP, Opioid system, Morphine group.