HPTLC and antibacterial analysis of extracts of Cressa cretica Linn
Journal name: Ancient Science of Life
Original article title: HPTLC and antibacterial analysis of extracts of Cressa cretica Linn
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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G. Suganthi, Shubashini K. Sripathy, K. Manian
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: HPTLC and antibacterial analysis of extracts of Cressa cretica Linn
Year: 2008
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Cressa cretica L., known as Rudanti in traditional Indian medicine, is recognized for its various therapeutic properties, including antibilious, antitubercular, and expectorant effects. It has been traditionally utilized in treating conditions such as constipation, leprosy, asthma, and urinary disorders. Despite its extensive use, there has been limited research on the antibacterial properties of this plant. The present study aims to investigate the phytochemical constituents of C. cretica through HPTLC analysis and assess its antibacterial activity against various pathogens, building upon existing literature that highlights its antifungal activities.
Phytochemical Screening and Antibacterial Activity
The study involved the extraction of phytoconstituents from air-dried, powdered C. cretica using solvents such as hexane, chloroform, ethyl acetate, and ether. The extracts underwent HPTLC analysis to identify the number and type of compounds present, revealing various Rf values corresponding to 11 compounds, particularly in the chloroform extract. Furthermore, the antibacterial activity of these extracts was tested against four microorganisms, including Escherichia coli and Staphylococcus aureus. Results indicated that all extracts, except for the hexane extract, exhibited significant antibacterial activity, particularly effective against Proteus spp., compared to the control.
Conclusion
The findings of this investigation underscore the potential of Cressa cretica as a source of bioactive compounds with antibacterial properties. The presence of multiple phytochemical constituents and their demonstrated antibacterial effects provide a scientific basis for the traditional use of this plant in herbal medicine. Given the increasing emergence of antibiotic-resistant strains of bacteria, further research and development of plant-derived antibiotics like those from C. cretica could contribute significantly to modern pharmacology and the treatment of infectious diseases.
FAQ section (important questions/answers):
What are the traditional medicinal uses of Cressa cretica?
Cressa cretica is used traditionally for its antibilious, antitubercular, and expectorant properties. It's also utilized for treating constipation, leprosy, asthma, and urinary issues, and is known as Rudanti in Ayurvedic medicine.
What phytoconstituents are found in Cressa cretica?
Phytochemical screening has identified the presence of alkaloids, coumarins, and steroids in Cressa cretica. Previous studies have also indicated its antifungal activity against various fungi.
How was the antibacterial activity of Cressa cretica tested?
The antibacterial activity was tested by measuring the zone of inhibition against four microorganisms using various extracts of Cressa cretica. Results showed considerable antibacterial activity, particularly against E. coli and Staphylococcus aureus.
What extraction methods were used for Cressa cretica?
The air-dried powdered plant was extracted successively using hexane, chloroform, ethyl acetate, and ether through a Soxhlet extraction method. Alkaloid extraction was also performed, followed by HPTLC analysis of the extracts.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “HPTLC and antibacterial analysis of extracts of Cressa cretica Linn�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the ability of a substance or extract to elicit a biological response, particularly in terms of therapeutic effects. In the context of this study, it pertains to the antibacterial activity of extracts from Cressa cretica L. that demonstrate efficacy against various pathogens.
2) Antibiotic (Antibacterial):
Anti-bacterial is synonymous with antibacterial and denotes substances that combat bacterial growth. The term underlines the focus of the research on Cressa cretica's extracts, assessing their capacity to act against specific bacterial strains, highlighting the plant's medicinal value in traditional healing practices.
3) Phytochemical:
Phytochemical refers to compounds produced by plants, often leading to various health benefits. In the context of this study, phytochemicals from Cressa cretica are examined for their biological activities, particularly their antibacterial properties, contributing to the understanding of their potential in drug development.
4) Rudanti (Rudamti):
Rudanti is the name attributed to Cressa cretica in traditional Indian medicine, indicating its significance and historical context in Ayurvedic healing. Its mention emphasizes the cultural and medicinal relevance of the plant as a natural remedy for various ailments in local practices.
5) Substance:
Substance refers to any form of matter with a specific composition. In this study, it relates to the various extracts and chemical compounds derived from Cressa cretica, which are analyzed for their biological activity, underpinning the research's goal to identify effective medicinal agents.
6) Flavonoid:
Flavonoid is a class of phytochemicals widely recognized for their health benefits, including antioxidant and antibacterial properties. Their mention in the context of Cressa cretica suggests that this plant may be a potential source of flavonoids, highlighting its importance in traditional medicine and pharmacological research.
7) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing disease. This term encapsulates the aim of the research—to investigate Cressa cretica for its medicinal properties and explore its potential in developing new treatments for infectious diseases from natural sources.
8) Leprosy:
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Its inclusion in the discussion of Cressa cretica highlights the plant's traditional use in treating serious illnesses and underlines the relevance of exploring natural remedies in the context of contemporary medical research.
9) Science (Scientific):
Science refers to the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In this study, the term signifies the scientific methods employed to analyze Cressa cretica's extracts, validating traditional knowledge with empirical evidence.
10) Blood:
Blood is a vital fluid that delivers necessary substances to the body's cells while transporting waste products away. Its mention in relation to Cressa cretica signifies the plant's role in traditional remedies that claim to enrich or purify the blood, reflecting its cultural significance.
11) Ashan (Asan, Asan):
Asan appears to refer to a state or quality, possibly linked to traditional practices or beliefs in natural healing. Though less prominent in the study's focus, its inclusion suggests the cultural and holistic perspectives surrounding the use of Cressa cretica in indigenous medicine.
Other Science Concepts:
Discover the significance of concepts within the article: �HPTLC and antibacterial analysis of extracts of Cressa cretica Linn�. Further sources in the context of Science might help you critically compare this page with similair documents:
Chronic disease, Traditional medicine, Herbal medicine, Antibacterial activity, Phytochemical screening, Zone of inhibition, HPTLC analysis, Diuretic, Ethanol extract, Leaf decoction, Bioactive compound, Phytoconstituent, Microorganisms tested, Soxhlet extraction procedure, Alkaloid extraction, Synthetic substances.