Efficacy of Achyranthes aspera on Lipid Profile in Rats Fed Sesame Oil
Journal name: Ancient Science of Life
Original article title: Hypolipidemic Efficacy of Achyranthes aspera on Lipid Profile in Sesame oil fed Rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Dr S. Krishnakumari, K. Priya
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Hypolipidemic Efficacy of Achyranthes aspera on Lipid Profile in Sesame oil fed Rats
Year: 2006
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study conducted by Dr. S. Krishnakumari and Priya K. focuses on the antihyperlipidemic effects of Achyranthes aspera in rats fed a diet rich in sesame oil. Hyperlipidemia, characterized by elevated levels of cholesterol and triglycerides in the blood, is a significant risk factor for various cardiovascular diseases, including atherosclerosis and heart attacks. The research aims to evaluate the impact of Achyranthes aspera on lipid profiles, specifically looking at serum and tissue cholesterol, triglycerides, phospholipids, free fatty acids, and lipoproteins such as HDL, LDL, and VLDL in experimental rats.
Impact on Lipid Profile
One important concept highlighted in the study is the significant effect of Achyranthes aspera on lipid profiles in rats subjected to a high-fat diet. The results show that the atherogenic diet led to increased levels of cholesterol, triglycerides, and other lipids in both serum and tissues of the rats. However, when treated with Achyranthes aspera, there was a marked reduction in these lipid levels, particularly in serum cholesterol and triglycerides, along with a significant increase in HDL levels. This suggests that Achyranthes aspera might aid in the management of hyperlipidemia by reducing harmful lipoproteins (LDL and VLDL) while promoting beneficial ones (HDL). This dual action potentially helps in mitigating risks associated with vascular diseases and supports cardiovascular health.
Conclusion
In conclusion, the study demonstrates that Acheranthes aspera possesses noteworthy antihyperlipidemic properties that can effectively counteract the adverse effects of diets high in sesame oil. This herbal treatment appears to normalize lipid profiles by decreasing harmful lipid levels while increasing protective HDL, thereby highlighting the plant's therapeutic potential in managing hypercholesterolemia and its related complications. Further research is recommended to isolate the active antihyperlipidemic components of Achyranthes aspera, which could lead to new opportunities for dietary or supplemental interventions aimed at improving cardiovascular health.
FAQ section (important questions/answers):
What is the purpose of the study on Achyranthes aspera?
The study aimed to evaluate the antihyperlipidemic effect of Achyranthes aspera on lipid profiles in rats fed a high-sesame oil diet, assessing various lipid parameters.
How was the plant extract of Achyranthes aspera prepared?
The aqueous extract was prepared by grinding fresh Achyranthes aspera seeds with water in a ratio of 1:10, allowing for the effective extraction of its beneficial properties.
What were the main findings regarding serum lipid profiles?
The study found that Achyranthes aspera treatment significantly reduced cholesterol, triglycerides, and the atherogenic index, improving lipid profiles in the experimental rats compared to control and oil-treated groups.
What is the significance of HDL and LDL levels in the study?
Higher HDL levels are desirable for reducing cardiovascular disease risk, while increased LDL levels indicate a higher risk. Achyranthes aspera treatment improved HDL and decreased LDL, suggesting its potential for heart health.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淓fficacy of Achyranthes aspera on Lipid Profile in Rats Fed Sesame Oil鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Anjali (A帽jali, A帽jal墨, 膧帽jali, Amjali):
Anjali refers to one of the locally available and widely used brands of sesame oil in the study. The use of specific oil brands is relevant to understanding the source of dietary fats that may influence the lipid profiles of the experimental rats during the research on the hypolipidemic efficacy of Achyranthes aspera.
2) Blood:
Blood is essential for transporting nutrients, gases, and waste throughout the body. In this study, blood samples were collected from the rats to analyze the lipid profile, providing insights into how the Achyranthes aspera treatment affected cholesterol and other lipids associated with hyperlipidemia in the context of dietary influences.
3) Diet:
Diet refers to the specific nutritional regimen provided to the experimental rats, which included sesame oil and atherogenic components. The type of diet is fundamental in assessing how different fats influence lipid metabolism, and how the inclusion of Achyranthes aspera can potentially reverse hyperlipidemic conditions as observed in the study.
4) Science (Scientific):
Science, in this context, encompasses the systematic study and experimentation involved in understanding the effects of Achyranthes aspera on lipid profiles in rats. The scientific approach taken in this research aims to establish empirical evidence for the hypolipidemic properties of this plant, contributing to nutritional and pharmacological knowledge.
5) Water:
Water is a critical component in the preparation of the aqueous extract of Achyranthes aspera, which was administered to the experimental rats. The solvent's role is crucial for extracting the active compounds from the plant, thus influencing the efficacy of the treatment and its potential hypolipidemic activity.
6) Drug:
Drug refers to any substance used in the treatment, prevention, or diagnosis of a disease. In this study, Achyranthes aspera is being investigated for its potential as a natural drug or treatment for hyperlipidemia, based on its traditional medicinal uses and scientific evaluation of its lipid-lowering effects.
7) Medicine:
Medicine encompasses both the practice and substances used for the diagnosis and treatment of diseases. This research highlights how Achyranthes aspera may offer a medicinal solution to hyperlipidemia, illustrating the intersection of traditional medicine and modern scientific research in addressing health issues related to lipid metabolism.
8) Activity:
Activity in this study refers to the biological effects and the specific hypolipidemic actions of Achyranthes aspera on lipid profiles. The term is important for demonstrating the plant's efficacy in laboratory settings, leading to a better understanding of how natural substances can influence health positively.
9) Sesamum indicum:
Sesamum indicum is the scientific name for sesame, the seeds of which were used to prepare the oil fed to the rats. The nutritional profile of sesame oil is relevant to the study as its fatty acid composition can significantly affect lipid metabolism and is integral for understanding the context surrounding hyperlipidemia.
10) Discussion:
Discussion is a critical section of the study that interprets and analyzes the results obtained from the experiments. It provides insight into how Achyranthes aspera shows promise as a treatment for hyperlipidemia, placing the findings in a broader framework of existing research and highlighting implications for future studies.
11) Knowledge:
Knowledge refers to the understanding gained through research and experience. In this context, knowledge regarding the hypolipidemic effects of Achyranthes aspera contributes to the existing body of information on natural products in medicine and nutrition, ultimately informing potential therapeutic approaches for managing hyperlipidemia.
12) Substance:
Substance refers to any material with a definite composition, such as the extract of Achyranthes aspera used in this study. Understanding the biochemical properties of this substance is crucial for evaluating its hypolipidemic effects on lipid profiles, aiding in the development of plant-based therapies in modern medicine.
13) Incision:
Incision refers to the surgical cut made to collect blood samples from the experimental rats. This procedure is necessary for obtaining serum to analyze lipid profiles. The methodical approach in making incisions ensures that the samples are collected properly, reducing stress on the animals and increasing data reliability.
14) Botany:
Botany is the scientific study of plants. This discipline is relevant to the research as it ensures the correct identification and understanding of Achyranthes aspera, allowing researchers to analyze its medicinal properties systematically. A robust botanical foundation is necessary for tapping into the therapeutic potential of plant species.
15) Priya (Priy膩):
Priya refers to one of the researchers involved in the study of Achyranthes aspera. The inclusion of researchers signifies collaboration and expertise, which are crucial in ensuring the scientific rigor and credibility of the findings presented in the study related to lipid profiles and hyperlipidemia.
16) Milk:
Milk is an ingredient included in the atherogenic diet given to the experimental rats. Its relevance lies in its nutritional composition, which may influence the overall lipid profile when combined with sesame oil and other components, thereby providing context on dietary impacts on hyperlipidemia in the study.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Efficacy of Achyranthes aspera on Lipid Profile in Rats Fed Sesame Oil鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Achyranthes aspera, Sesame oil, Research Scholar, Traditional medicine, Statistical analysis, Cholesterol, Lipid profile, Free fatty acid, Experimental rats, Atherogenic Index, High-fat diet, Hypercholesterolemia, Analytical Procedure, Triglyceride, Plant Extract, Lipoproteins, Atherogenic Diet, Cholesterol absorption, Department of Biochemistry, Hypolipidemic drug, Animal breeding, Arteriosclerosis, Biochemical variables.