Validation of two siddha drugs for antiulcer effect in rats.
Journal name: Ancient Science of Life
Original article title: Pharmacological validation of two siddha drugs(parpams) for antiulcer effect in albinorats: a preliminary study
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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A. Thanga Thirupathi, R. Venkatanarayanan, R. Hemalatha
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Pharmacological validation of two siddha drugs(parpams) for antiulcer effect in albinorats: a preliminary study
Year: 2002
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The Siddha system of medicine, one of India's oldest healing traditions, has faced challenges in recent years due to the rise of modern medical practices and increasing patient dissatisfaction with allopathic approaches. In light of this, there is renewed interest in alternative medicine. The study presented evaluates the antiulcer effects of two specific Siddha formulations鈥擲angu Parpam and Silasathu Parpam鈥攐n albino rats. These formulations have been traditionally used in Siddha medicine for various ailments, including ulcers, although previous research into their pharmacological efficacy in modern scientific terms has been limited.
Pharmacological Validation of Siddha Drugs
The investigation of Sangu Parpam and Silasathu Parpam's effects was conducted using two experimental ulcer models: the Phenylbutazone-induced ulcer model and the Stress-induced ulcer model. In the Phenylbutazone model, rats were administered the drug to induce gastric mucosal damage, and the Siddha formulations and a standard drug (Ranitidine) were given 30 minutes prior to assess their gastroprotective effects. The Stress-induced model involved cold and restraint conditions, reflecting the central nervous system's role in ulcer formation. Through this methodology, the study aimed to evaluate the efficacy of the Siddha drugs compared to standard treatments, with the results suggesting their potential as effective antiulcer agents.
Conclusion
The findings of this preliminary study indicate that both Sangu Parpam and Silasathu Parpam exhibit promising antiulcer properties. This research opens avenues for further exploration into the standardization and toxicological assessment of Siddha medicines. By validating these traditional formulations through scientific methods, there is potential not only to enhance their application but also to integrate alternative medicine effectively into the broader healthcare landscape. The authors emphasize the necessity for additional studies to confirm these results and better understand the mechanisms underlying the observed benefits of these Siddha drugs.
FAQ section (important questions/answers):
What are Sangu Parpam and Silasathu Parpam used for?
Sangu Parpam and Silasathu Parpam are Siddha formulations primarily used as antiulcer agents. They are traditionally utilized for various ailments, including diarrhea, colic, peptic ulcers, asthma, chronic cough, and tuberculosis.
Why is there dissatisfaction with the allopathic medical system?
Dissatisfaction arises from increasing costs, side effects, and the perception of unnecessary treatments. Additionally, the focus on disease rather than holistic health and patient involvement has led many to explore alternative medical systems.
How were the antiulcer effects of the drugs tested in this study?
The antiulcer effects of Sangu Parpam and Silasathu Parpam were evaluated using two models: Phenylbutazone-induced and stress-induced ulcers in albino rats. The drugs were administered prior to inducing ulcers to assess their gastroprotective effects.
What further research is suggested for these Siddha drugs?
Future research should focus on standardizing the drugs, conducting toxicological studies, and evaluating their effects using additional ulcer models that haven't been explored yet, to enhance understanding and credibility.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淰alidation of two siddha drugs for antiulcer effect in rats.鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A substance used to diagnose, cure, or prevent disease or to enhance physical or mental well-being. In the context of Siddha medicine, drugs are derived from natural sources and are utilized for their therapeutic effects. The study focuses on validating the anti-ulcer properties of specifically selected Siddha drugs.
2) Medicine:
The science and practice of the diagnosis, treatment, and prevention of disease, medicine incorporates diverse practices and systems. Siddha medicine, as highlighted in the study, is one of the oldest systems and emphasizes a holistic approach, targeting root causes instead of merely alleviating symptoms.
3) Siddha (Siddh膩):
Siddha refers to an ancient Indian medical system that originated in Tamil Nadu, characterized by a holistic approach to health. This system utilizes natural remedies, rituals, and a balance of body, mind, and spirit. The study investigates the pharmacological validation of Siddha formulations for their potential anti-ulcer effects.
4) Ulcer:
A sore that develops on the lining of the stomach or intestine, ulcers can cause significant pain and digestive issues. The study specifically explores the anti-ulcer effects of chosen Siddha drugs on albino rats, aiming to establish their efficacy compared to standard treatments like ranitidine.
5) Water:
An essential solvent and medium for life, water is critical in biological processes and is used in various medical formulations. In the study, it serves as a solvent for administering Phenylbutazone and reflects the importance of hydration for the health and maintenance of experimental animals.
6) Pharmacological:
Relating to the study of drugs and their effects on living systems, pharmacological validation is crucial in substantiating traditional treatments. This study aims to apply pharmacological principles to evaluate the effectiveness of Siddha drugs against ulcers, bringing scientific rigor to traditional medical practices.
7) Pharmacology:
The branch of medicine that explores drug action, pharmacology encompasses the study of drug composition, effects, and therapeutic efficacy. The study on Siddha formulations utilizes pharmacological methods to assess their anti-ulcer properties, highlighting the need for scientific evidence in alternative medicine.
8) Tuberculosis:
A potentially serious infectious disease primarily affecting the lungs, tuberculosis is treated with specific antibiotics. In the context of Siddha medicine, the referenced formulations are used for various ailments, including tuberculosis, suggesting their broad therapeutic applications beyond just anti-ulcer effects.
9) Knowledge:
In the medical field, knowledge encompasses the understanding of diseases, treatments, and the mechanisms of action of drugs. The Siddha system, though ancient, offers wisdom that researchers aim to validate through modern scientific methods, thus bridging traditional and contemporary healthcare.
10) Quality:
Quality signifies the degree of excellence and standardization in pharmaceuticals. The study discusses the lack of quality control in Siddha formulations and emphasizes the necessity for proper standardization and validation to ensure the safety and efficacy of these traditional medicines.
11) Science (Scientific):
A systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe, science is foundational in validating medicinal claims. The study applies scientific methods to assess Siddha medicine, aiming to integrate ancient practices with modern scientific validation.
12) Bhasma (Bhasman):
A Sanskrit term signifying ash or calcined substances, Bhasma represents a category of Ayurvedic medicine used for its therapeutic properties. The Siddha drugs in the study, termed 'Parpam,' are analogous to Bhasma and are prepared through calcination processes, enhancing their medicinal effectiveness.
13) Tanka (峁琣峁卥a, Ta峁卥a, 峁琣峁僰a, 峁琣nka, Tamka, T膩峁卥膩, 峁琣nk膩):
Referring to A. Thanga Thirupathi, one of the authors of the study, the inclusion of individuals in research highlights the collaborative effort required to undertake pharmacological evaluations. Individual contributions are pivotal in advancing the understanding and validation of traditional medicinal practices.
14) Diet:
The customary food and drink consumed by living organisms, diet plays a significant role in overall health and can influence medical conditions. In the study, the rats are provided with a standard diet, ensuring controlled conditions for evaluating the anti-ulcer effects of Siddha drugs.
15) Ghi (Gh墨, Ghee):
A clarified butter commonly used in Indian cooking and traditional medicine, ghee serves as a solvent for certain formulations in Siddha medicine. In the study, the use of ghee reiterates the traditional practices of preparing medicated formulations for improved absorption and efficacy.
16) Milk:
A nutrient-rich liquid produced by mammals, milk plays various roles in nutrition and traditional medicine. In the specific context of the study, milk is referenced as a source for ghee, illustrating the utilization of dairy products in the preparation of medicinal remedies.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Validation of two siddha drugs for antiulcer effect in rats.鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Curative medicine, Standardization and quality control, Siddha system of medicine, Ancient Science of life, Toxicological studies, Experimental data, Stress induced ulcer model, Gastroprotective effect, Siddha drug, Antiulcer effect, Ulcer score, Pharmacological validation.