Anticonvulsant effect of Cardiospermum halicacabum in rats.
Journal name: Ancient Science of Life
Original article title: Anticonvulsant action of petroleum ether fraction of Cardiospermum halicacabum against electroshock induced Convulsion in rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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T. Vetrichelvan, C. Lakshmi Narasimhan, R. Venkatramani
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anticonvulsant action of petroleum ether fraction of Cardiospermum halicacabum against electroshock induced Convulsion in rats
Year: 2000
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the anticonvulsant properties of the petroleum ether fraction of Cardiospermum halicacabum, a climbing herb found throughout India. This plant has been utilized in traditional medicine for various ailments, including rheumatism, tumors, and nervous disorders. Previous literature highlights its components, such as saponins and amino acids, which may contribute to its therapeutic effects. The research aims to evaluate the effectiveness of this herb against electroshock-induced convulsions in rats, contributing to the understanding of its potential medicinal applications.
Anticonvulsant Action of Cardiospermum Halicacabum
The experimental design involved dividing Wistar albino rats into two groups: one receiving the test drug and the other a control suspension. Administered at a dose of 350 mg/kg body weight, the petroleum ether extract of Cardiospermum halicacabum significantly reduced the duration of extensor and flexor components of tonic convulsions compared to the control group. The statistical analysis revealed a significant difference (p<0.05) in the outcomes, indicating that the plant extract possesses effective anticonvulsant properties when subjected to induced convulsions.
Conclusion
The findings of this study suggest that the petroleum ether fraction of Cardiospermum halicacabum has notable anticonvulsant effects, demonstrating its potential as a therapeutic agent in managing convulsions. The significant reduction in convulsion duration highlights the herb's efficacy and encourages further research into its active constituents and mechanisms. Continued exploration of such indigenous plants may lead to the development of novel treatments for neurological disorders, emphasizing the importance of traditional knowledge in modern pharmacology.
FAQ section (important questions/answers):
What is Cardiospermum halicacabum used for in traditional medicine?
Cardiospermum halicacabum has been traditionally used for treating rheumatism, reducing swelling, and is noted for its potential anticancerous properties, among other uses related to asthma, amenorrhea, and nervous disorders.
What was the purpose of this study on Cardiospermum halicacabum?
The study aimed to evaluate the anticonvulsant effects of the petroleum ether fraction of Cardiospermum halicacabum against electroshock-induced convulsions in rats, highlighting its potential therapeutic benefits.
How was the anticonvulsant activity tested in this study?
Wistar albino rats were divided into two groups, with one group receiving Cardiospermum halicacabum orally. After one hour, convulsions were induced, and the duration of various convulsive phases was recorded and analyzed.
What were the findings regarding the anticonvulsant effects of the extract?
The results showed that the extract of Cardiospermum halicacabum significantly reduced the duration of both extensor and flexor components of tonic convulsions compared to the control group, indicating its anticonvulsant potential.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anticonvulsant effect of Cardiospermum halicacabum in rats.�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of this study, 'Drug' refers to the petroleum ether fraction of Cardiospermum halicacabum, which is evaluated for its anticonvulsant properties against electroshock-induced convulsions in rats. The effectiveness of this plant extract is measured through specific doses, highlighting its potential medicinal applications in treating seizures and related disorders.
2) Water:
Water serves as a critical component in the preparation of the suspension used for administering the extract of Cardiospermum halicacabum to the rats. It ensures the proper dissolution and bioavailability of the extract, thus facilitating accurate dosing and enhancing the reliability of the experimental outcomes in evaluating anticonvulsant action.
3) Discussion:
The 'Discussion' section of a research paper interprets the findings of the study, comparing the results to existing literature and highlighting the significance of the anticonvulsant effects observed. This part critically assesses the implications of the research, the potential for clinical applications, and suggestions for future studies on Cardiospermum halicacabum.
4) Stiffness:
In this study, 'Stiffness' is mentioned in relation to the medicinal properties of Cardiospermum halicacabum, indicating traditional uses to alleviate conditions characterized by muscle tightness and rigidity. This quality suggests broader therapeutic potentials beyond anticonvulsant effects, reinforcing the herb's relevance in holistic and complementary medicine approaches.
5) Swelling:
The term 'Swelling' indicates another medicinal property of Cardiospermum halicacabum, as the plant is noted for its utility in reducing swelling associated with tumors and rheumatism. This anti-inflammatory characteristic adds to its profile as a natural remedy, suggesting it may have multi-faceted therapeutic applications in treating various ailments.
6) Activity:
'Activity' refers specifically to the anticonvulsant activity demonstrated by the petroleum ether fraction of Cardiospermum halicacabum in experimental settings. This term emphasizes the importance of assessing the efficacy and potency of the drug in controlling convulsions, thus contributing valuable knowledge toward the development of alternative treatments for epilepsy and related conditions.
7) Lakshmi (Lakṣmī):
The name 'Lakshmi' refers to one of the authors of the study, who contributed to the research on the anticonvulsant action of Cardiospermum halicacabum. Author citations are crucial in academic research, as they provide credit for work and insights, establishing the reliability and integrity of the findings presented in the study.
8) Science (Scientific):
'Science' encapsulates the systematic investigation and exploration of phenomena, including medicinal properties of plants. In this study, the focus on scientific methods validates the research outcomes, enhancing the credibility of traditional knowledge regarding Cardiospermum halicacabum as a potential anticonvulsant, thus bridging natural and scientific approaches to medicine.
9) Botany:
'Botany,' the study of plants, is relevant here as it provides a foundational understanding of Cardiospermum halicacabum's botanical characteristics, growth, and pharmacological properties. Knowledge from botany informs genetic, ecological, and morphological aspects, which are essential for recognizing the therapeutic potential of this herb and its applications in medicine.
10) Hand:
'Hand' in this context refers to the 'hand homogenizer,' a laboratory instrument used to prepare the suspension of Cardiospermum halicacabum extract. Proper homogenization ensures a uniform distribution of the extract for controlled dosing in the experimental setup, emphasizing the importance of methodological precision in yielding reliable research results.
Other Science Concepts:
Discover the significance of concepts within the article: �Anticonvulsant effect of Cardiospermum halicacabum in rats.�. Further sources in the context of Science might help you critically compare this page with similair documents:
Cardiospermum halicacabum, Medicinal properties, Control group, Statistically Significant, Petroleum ether fraction, Wistar albino rat, Climbing herb, Anticonvulsant action.