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Hepatoprotective activity of navayasa curna and hasava combination

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Journal name: Ancient Science of Life
Original article title: Hepatoprotective activity of navayasa curna and hasava combination
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Muzaffer Alam, K.K Shanmuga Dasan, T. Susan, S. Joy


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Hepatoprotective activity of navayasa curna and hasava combination

Year: 1997

Copyright (license): CC BY-NC-SA


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Summary of article contents:

Introduction

The liver plays a pivotal role in numerous metabolic activities and is susceptible to damage from various environmental factors, chemicals, and drugs, leading to the elevation of markers such as alkaline phosphatase and transaminases (GPT and GOT). In traditional Indian medicine, particularly Ayurveda, herbs and formulations are utilized to repair liver damage. This study investigates the hepatoprotective effects of a combination of Navayasa curna and Lohasava against carbon tetrachloride-induced liver injury in albino rats, which serves as a model for studying liver dysfunction.

Mechanism of Hepatoprotection

The research findings indicate that the combination of Navayasa curna and Lohasava significantly mitigates liver damage induced by carbon tetrachloride, evidenced by a reduction in liver weight, alkaline phosphatase, and transaminase levels in both liver and serum. The study reports that the drug mixture does not significantly affect liver and serum proteins or glycogen levels, suggesting that it protects the integrity of cellular membranes and reduces enzyme leakage. The hepatoprotective effect is believed to be linked to the presence of active compounds in the formulations, such as biflavonoids from Phyllanthus emblica and curcumin from Curcuma longa, which have documented anti-hepatotoxic properties. Collectively, these findings underscore the potential of Ayurvedic formulations in preventing chemical-induced liver damage.

Conclusion

The study concludes that the combination of Navayasa curna and Lohasava shows promising hepatoprotective activity against carbon tetrachloride-induced liver injury, highlighting the efficacy of Ayurvedic medicines in liver health management. This research reinforces the notion that traditional formulations can provide therapeutic benefits in mitigating liver damage, suggesting a valuable avenue for further exploration in both alternative and integrative medicine strategies.

FAQ section (important questions/answers):

What is the focus of the study conducted by Muzaffer Alam and colleagues?

The study evaluates the hepatoprotective activity of Navayasa curna mixed with Lohasava against liver injury induced by carbon tetrachloride in albino rats.

What were the primary findings regarding liver enzymes and weight?

The treatment with Navayasa curna in Lohasava significantly reduced liver weight, alkaline phosphatase, GOT, and GPT activities, indicating protection against liver damage.

What effect did the drugs have on serum cholesterol levels?

The combination of Navayasa curna and Lohasava significantly lowered serum cholesterol levels, suggesting a beneficial impact on lipid metabolism in the context of liver injury.

What components of the treatments are noted for their hepatoprotective effects?

Phyllanthus emblica and Curcuma longa, found in Lohasava and Navayasa curna, are recognized for their antihepatotoxic properties, contributing to the protective effects observed in the study.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Hepatoprotective activity of navayasa curna and hasava combination�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Curna (CÅ«rṇa, CurnÄ):
Curna refers to a traditional Ayurvedic powder formulation that is composed of herbal ingredients. In the context of the study, it specifically relates to the preparation method used for Navayasa curna, which is a herbal compound aimed at promoting liver health. Its relevance lies in its mixability and bioavailability when combined with other substances like Lohasava.

2) Navayasacurna (NavÄyasacÅ«rṇa, Navayasa-curna):
Navayasa-curna is an Ayurvedic formulation significant for its hepatoprotective properties. In this research, it is analyzed for its effectiveness against carbon tetrachloride-induced liver injury. The formulation serves as a basis for understanding the synergy of its components and their roles in maintaining liver health.

3) Navayasa (NavÄyasa):
Navayasa is part of the name of a specific Ayurvedic powder (curna) with a focus on liver health. It encompasses a blend of herbal ingredients that contribute to its therapeutic effects. Its relevance is highlighted in the study as a principal factor influencing the observed hepatoprotective activity.

4) Drug:
The term 'drug' in this context refers to the medicinal agents, namely Navayasa curna and Lohasava, utilized in the study to evaluate their protective action on the liver. It underscores the importance of understanding how these compounds interact with biological pathways, particularly those related to liver function and repair.

5) Activity:
Activity in the study refers to the physiological and biochemical responses elicited by the administration of Navayasa curna and Lohasava. The term encompasses the observed healing effects and reductions in liver injury markers following treatment, signifying the preparations' effectiveness in promoting liver health.

6) Medicine:
Medicine describes the broader category of health-related interventions, including Ayurvedic formulations like Navayasa curna and Lohasava. The relevance lies in understanding these formulations as comprehensive systems aimed at disease management, particularly in liver-related afflictions, demonstrating the integration of traditional practices into therapeutic strategies.

7) Curcuma longa:
Curcuma longa, commonly known as turmeric, is an essential herb in Ayurveda known for its anti-inflammatory and antioxidant properties. Its relevance in the study arises from its inclusion in Lohasava, contributing to the formulation's hepatoprotective effects, particularly due to constituents like curcuminoids that support liver function.

8) Discussion:
Discussion refers to the section of the study where findings are interpreted and contextualized within existing research. It elucidates the implications of the results obtained from the experiments, linking them to previous knowledge and highlighting the significance of using Navayasa curna and Lohasava in liver protection.

9) Pandu (PÄṇá¸u, Paṇá¸u, PandÅ«, Pamdu, Pamde):
Pandu, a term used in Ayurveda, refers to a specific condition characterized by anemia or jaundice. Its relevance to this study lies in the relationship between the liver's health and these conditions, emphasizing how Navayasa curna and Lohasava can potentially influence these health issues through their treatment.

10) Water:
Water is a fundamental solvent involved in the preparation of Ayurvedic formulations, acting as a medium for dissolving and combining herbal ingredients. In this study, it is integral as part of the liver homogenization process, enabling proper analysis of the biochemical parameters relevant to liver health.

11) Phyllanthus emblica:
Phyllanthus emblica, or amla, is a medicinal plant recognized for its liver-protective qualities. In the context of this study, its inclusion in Lohasava is pertinent, as it contributes to the hepatoprotective action demonstrated by the combination with Navayasa curna in mitigating liver injury.

12) Ayurveda (Ä€yurveda, Ayus-veda):
Ayurveda is a holistic medicinal system originating from India, emphasizing balance and natural healing. Its relevance is significant in the study as it frames the conceptual basis for the use of Navayasa curna and Lohasava, reflecting traditional practices targeting liver health and overall well-being.

13) Shvayathu (Åšvayathu, Svayathu):
Svayathu, in Ayurvedic terminology, is often related to disorders affecting digestion and metabolic processes. Its inclusion in the context of the study aligns with the focus on liver health, indicating the holistic view of treatment approaches targeting interconnected bodily functions through formulations like Navayasa curna and Lohasava.

14) Prameha:
Prameha denotes a group of metabolic disorders within Ayurvedic medicine, particularly relating to diabetes and its complications. Its relevance to the study persists in understanding how liver health impacts such conditions, noting the broader implications of using hepatic support formulations like Navayasa curna and Lohasava.

15) Jathara (Jaá¹­hara, JÄá¹­hara):
Jathara refers to the digestive system in Ayurveda, signifying its connection to overall metabolic functions. In the study, Jathara's relevance underscores the importance of liver health within digestive processes, displaying how Ayurvedic formulations can impact these interconnected systems, particularly in the context of Navayasa and Lohasava.

16) Science (Scientific):
Science refers to the systematic study and empirical investigation of phenomena. In this context, it highlights the methodological approach of the research, emphasizing the need for rigorous scientific validation of traditional Ayurvedic preparations like Navayasa curna and Lohasava in addressing liver-related ailments.

17) Kamala (KamalÄ, KÄmalÄ, KÄmÄla, Kama-la):
Kamala is an Ayurvedic term that translates to jaundice, a condition closely associated with liver function. Its relevance connects the study to liver health management, showcasing how formulations like Navayasa curna are advocated in treating such conditions through enhancing liver protective mechanisms.

18) Pidaka (PÄ«á¸aka):
Pidaka relates to swellings or lumps in Ayurvedic terminology and indicates imbalances in bodily humors. Its relevance to the study lies in its classification within Ayurvedic conditions, suggesting that formulations like Navayasa curna may play a role in balancing bodily functions and mitigating liver-related issues.

19) Repair:
Repair signifies the restoration processes within the body, particularly in terms of organ health. In this study, it is relevant in the context of the hepatoprotective effects of Navayasa curna and Lohasava, emphasizing their roles in promoting the healing and recovery of liver function following injury.

20) Gulma:
Gulma refers to abdominal masses or growths recognized in Ayurvedic medicine. Its relevance in the context of the study pertains to understanding how the health of the liver impacts gastrointestinal conditions, pointing out the significance of using targeted therapies like Navayasa curna and Lohasava for therapeutic effects.

21) Glass:
Glass, in this context, relates to the laboratory equipment used for blood collection and serum separation within the study. It emphasizes the importance of using appropriate materials to ensure accurate measurement and observance of biochemical parameters critical to assessing the effects of the formulations.

22) Dasa (DÄsa, DaÅ›Ä, DasÄ, DaÅ›a, DÄÅ›a, DaÅ›an, Dasha, Dashan):
Dasan refers to K.K. Shanmuga Dasan, one of the authors contributing to the research. The relevance of the author's input is crucial, as it combines expertise and knowledge that lend credibility to the study, enhancing the understanding of the efficacy of Navayasa curna and Lohasava.

23) Blood:
Blood is a vital fluid in the body that carries nutrients and waste products. In the context of the study, blood samples were used to assess serum biochemical parameters, enabling the evaluation of the liver's functional state and the impact of Navayasa curna and Lohasava on liver health.

24) Loha:
Loha, meaning iron in Sanskrit, is an essential mineral used in traditional Ayurvedic formulations. In this study, Loha plays a pivotal role as part of Lohasava, emphasizing its importance for liver health and how it is effectively utilized alongside Navayasa curna to enhance therapeutic outcomes.

Other Science Concepts:

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Discover the significance of concepts within the article: �Hepatoprotective activity of navayasa curna and hasava combination�. Further sources in the context of Science might help you critically compare this page with similair documents:

Curcuma longa, Phyllanthus emblica, Statistical analysis, Control group, Experimental design, Serum cholesterol, Hepatoprotective activity, Ayurvedic Drug, Protein content, Glycogen content, Alkaline phosphatase activity, Biochemical parameter, Glutamate transaminase, Albino rat.

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