Anti-inflammatory activities of some species of andrographis wall. (acanthaceae)
Journal name: Ancient Science of Life
Original article title: Anti-inflammatory activities of some species of andrographis wall. (acanthaceae)
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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S. Balu, C. Alagesaboopathi
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti-inflammatory activities of some species of andrographis wall. (acanthaceae)
Year: 1993
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study investigates the anti-inflammatory activities of three species of the plant Andrographis Wall., specifically Andrographis alata, A. paniculata, and A. lineate, using a carrageenin-induced rat paw edema model. Inflammation is a natural response characterized by redness, heat, pain, and swelling, which serves as a homeostatic mechanism to address tissue injury. The study aims to evaluate the extracts' efficacy in reducing inflammation phases: the initial response mediated by histamine and kinin systems, and the sustained response involving prostaglandins.
Efficacy of Andrographis Species in Reducing Inflammation
The research revealed significant differences in anti-inflammatory activity among the three tested species. The alcoholic extract of A. alata showed the most substantial inhibitory effect on inflammation, demonstrating a 52.84% reduction in edema during the histamine phase. In comparison, A. paniculata exhibited 39.76% activity, while A. lineate displayed only 12.54% effectiveness during the same phase. While all three extracts demonstrated moderate efficacy in the prostaglandin phase, A. lineate still achieved only 29.18% activity, indicating that A. alata stands out as the most effective species for managing inflammation in this study.
Conclusion
The findings provide compelling evidence supporting the use of Andrographis extracts, particularly A. alata, as potential therapeutic agents in managing inflammation. Given A. alata's superior performance in reducing edema, it could be further investigated for its mechanisms of action and potential clinical applications. Overall, the study highlights the importance of traditional medicinal plants in contemporary pharmacological research, paving the way for future exploration of their properties and benefits in treating inflammatory conditions.
FAQ section (important questions/answers):
What was the purpose of the study on Andrographis species?
The study aimed to investigate the anti-inflammatory activities of alcoholic extracts from three species of Andrographis using a rat model with carrageenin-induced paw edema.
Which species of Andrographis showed the highest anti-inflammatory activity?
Andrographis alata exhibited the highest anti-inflammatory activity, registering 52.84% effectiveness compared to the other species tested.
How were the effects of Andrographis extracts measured in rats?
The effects were measured by injecting carrageenin to induce inflammation and then assessing edema volume using the mercury displacement method at specified time intervals.
Did all Andrographis species show anti-inflammatory effects?
Yes, all three species demonstrated moderate anti-inflammatory effects, especially A. paniculata and A. alata during the histamine phase of inflammation.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-inflammatory activities of some species of andrographis wall. (acanthaceae)�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of this study, 'activity' refers to the degree of anti-inflammatory effects exhibited by different extracts of Andrographis species on induced inflammation in rats. It is quantified as a percentage, highlighting how effectively each extract mitigates inflammation compared to a control or standard drug, like phenylbutazone.
2) Inflammation:
'Inflammation' signifies the body’s response to injury or harmful stimuli, presenting classic signs like redness and swelling. It plays a crucial role in healing but can become problematic if persistent, as in the case studied where Carrageenin-induced inflammation serves as a model for evaluating the extracts' effectiveness in reducing inflammation.
3) Edema (Oedema):
'Edema' refers to the accumulation of fluid in body tissues, which is a key sign of inflammation. In this study, Carrageenin-induced edema in rats was measured to assess the anti-inflammatory properties of the Andrographis extracts. The mangement of edema is pivotal in evaluating treatment efficacy.
4) Drug:
In this context, 'drug' pertains to substances used to treat or alleviate symptoms of diseases or conditions. The study compares the anti-inflammatory activities of herbal extracts from Andrographis spp. with a conventional drug, phenylbutazone, to evaluate their effectiveness and potential as alternative therapeutic agents against inflammation.
5) Swelling:
'Swelling' is a biological response resulting from inflammation where tissues increase in size due to fluid accumulation. In this research, swelling was a primary indicator of the inflammatory response in rats after Carrageenin injection, and it was measured to determine the potential anti-inflammatory effects of the Andrographis extracts.
6) Discussion:
'Discussion' in scientific research serves as a critical section where findings are interpreted, compared with existing literature, and implications are drawn. Here, the discussion likely focuses on the implications of the results from the anti-inflammatory activities of Andrographis extracts and insights into their potential medicinal properties.
7) Science (Scientific):
'Science' embodies a systematic enterprise that builds and organizes knowledge about the universe. This study exemplifies science in action as researchers investigate the medicinal properties of Andrographis species, contributing to a broader understanding of natural remedies and their therapeutic applications in biology and medicine.
8) Botany:
'Botany' is the branch of biology that studies plants, their structure, functions, and interactions with their environment. The research focuses on specific plant species of Andrographis, showcasing the importance of botany in exploring plant-based solutions for health issues, specifically through examining the extracts' medicinal properties.
9) Water:
'Water' serves as a fundamental component in biological processes, acting as a solvent and medium for various biochemical reactions. In this study, the rats were provided with tap water as part of their sustenance, emphasizing the significance of hydration in experimental settings for maintaining the health of test subjects.
Other Science Concepts:
Discover the significance of concepts within the article: �Anti-inflammatory activities of some species of andrographis wall. (acanthaceae)�. Further sources in the context of Science might help you critically compare this page with similair documents:
Acute inflammation, Control group, Anti-inflammatory activity, Anti-inflammatory activities, Soxhlet extraction, Edema volume, Prostaglandin, Andrographis paniculata Nees, Carrageenin-induced inflammation.