Clinical evaluation of terminalia belerica in diarrhoea
Journal name: Ancient Science of Life
Original article title: Clinical evaluation of terminalia belerica in diarrhoea
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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Bhushan Patwardhan, K.K. Bhutani, P.S. Patki, S.V. Dange, D.V. Gore, D.I. Borole, R.B. Shirolkar, P.V. Paranjpe
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Clinical evaluation of terminalia belerica in diarrhoea
Year: 1990
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
Terminalia belerica, known as Behada, is a traditional Ayurvedic remedy recognized for its effectiveness against various ailments, particularly dysentery and diarrhoea. This study aimed to clinically evaluate the fruit of T. belerica for its therapeutic potential against infections caused by E. histolytica and other bacteria associated with intestinal distress. Conducted by a team of medical practitioners in Pune, the research focused on a cohort of 25 patients to assess the clinical efficacy of a bioactive fraction derived from the fruit. The findings indicate promising results that warrant further investigation into its use as an alternative treatment.
Efficacy of Terminalia Belerica
The study involved a controlled trial where patients received either the bioactive fraction (BAF) or a placebo. The treatment, administered at a dosage of 150 mg three times a day for a maximum period of 14 days, demonstrated significant results. Out of the 25 patients, 12 received BAF, with an impressive 11 responding positively to the treatment within two days. Improvements were observed in symptoms, stool consistency, and laboratory outcomes, with patients requiring an average of twelve tablets for recovery. Those treated with BAF showing negative tests for amoebic cysts and other pathogens, whereas the placebo group exhibited no such improvements, highlighting the effectiveness of T. belerica in managing diarrhoeal diseases.
Conclusion
This evaluation of Terminalia belerica underscores its potential as a novel therapeutic agent against dysentery and diarrhoea, particularly due to its efficacy and absence of side effects. The rapid improvement in patient symptoms within days reflects the promising nature of this Ayurvedic treatment amidst concerns regarding drug resistance in conventional therapies. Nevertheless, further studies are necessary to explore the active chemical constituents and their mechanisms of action to fully establish T. belerica's role in modern medicine as a viable alternative to existing antibacterial drugs.
FAQ section (important questions/answers):
What is Terminalia belerica and its traditional uses?
Terminalia belerica, known as Behada, is commonly used in Ayurveda for various ailments, particularly in treating dysentery and diarrhea.
What was the purpose of the study on Terminalia belerica?
The study aimed to evaluate the clinical efficacy of Terminalia belerica in treating acute and chronic cases of diarrhea and dysentery among patients.
What were the key findings of the clinical evaluation?
The study found that 11 out of 12 patients responded positively to the treatment, requiring an average of twelve tablets for recovery, with no observed side effects.
How did the treatment with BAF compare to the placebo?
Patients receiving the bioactive fraction (BAF) showed significant improvement in symptoms within 2-3 days, while the placebo group had ongoing symptoms, indicating BAF's effectiveness.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for 鈥淐linical evaluation of terminalia belerica in diarrhoea鈥�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' in the context of this study refers to Terminalia belerica, specifically its bioactive fraction, which is being evaluated for therapeutic efficacy against diarrhoea and dysentery caused by E. histolytica and various bacteria. The study investigates its potential as a safer alternative to traditional pharmaceutical drugs associated with adverse effects.
2) Activity:
In this study, 'Activity' pertains to the pharmacological effects of the bioactive fraction of Terminalia belerica. The documented amoebicidal and bactericidal actions demonstrate its capacity to inhibit pathogenic organisms responsible for dysentery. The successful clinical outcomes following treatment highlight the relevance of this activity in managing diarrheal diseases.
3) Behada (B膿ha岣嵞�, Beha岣嵞�):
Behada refers to the fruit of Terminalia belerica, a significant medicinal plant widely used in traditional Ayurvedic medicine. Its relevance lies in its historical use for treating ailments such as dysentery and diarrhoea, supporting the study's premise of exploring natural alternatives to contemporary pharmaceuticals for gastrointestinal issues.
4) Pharmacology:
Pharmacology in this context relates to the study of how Terminalia belerica's bioactive fraction interacts with biological systems to exert therapeutic effects. Understanding its pharmacological properties is crucial for justifying its use in clinical settings, assessing efficacy, and ensuring safety without the side effects commonly associated with synthetic drugs.
5) Discussion:
The 'Discussion' section provides critical analysis and interpretation of study findings. It addresses the implications of the observed results, compares them with established treatments, and suggests the potential for further research on Terminalia belerica's efficacy. The discussion underscores the importance of developing alternative treatments for chronic illnesses like amoebic dysentery.
6) Bibhitaka (Bibh墨taka):
Bibhitaka is another name for Terminalia belerica, emphasizing its cultural significance in Ayurvedic medicine. By using this nomenclature, the study acknowledges the plant's traditional usage and integrates ethnobotanical knowledge, enriching the understanding of its medicinal properties and applications alongside its scientific evaluation in clinical trials.
7) Triphala (Triphal膩, Tri-phala):
Triphala is a well-known Ayurvedic formulation consisting of three fruits, including Terminalia belerica. The reference to Triphala underscores the importance of Behada in traditional medicine, linking its individual therapeutic benefits to a broader legacy of herbal healing practices. This context adds value to the study's search for natural interventions.
8) Medicine:
Medicine in this study encompasses both conventional and alternative approaches to treating diarrhoea and dysentery. It highlights the interdisciplinary focus of the research, combining traditional practices with scientific evaluation, thus promoting a more holistic understanding of health care options available for gastrointestinal disorders.
9) Science (Scientific):
The term 'Science' signifies the application of rigorous research methodologies to validate the efficacy of Terminalia belerica as a treatment option. It underscores the study's reliance on empirical evidence, from clinical evaluations to biochemical assessments, aiming to bridge the gap between traditional knowledge and modern scientific inquiry.
10) Reason:
Reason in this context refers to the justification behind selecting Terminalia belerica for clinical evaluation. The initial identification of its medicinal properties through in vitro studies provided a scientific basis for exploring its therapeutic potential in addressing diarrhoea, enhancing understanding of the rationale behind its use in patient treatment.
11) Sugar:
In this study, 'Sugar' alludes to the biochemical components isolated from Terminalia belerica, contributing to its pharmacological profile. The presence of free sugars in the extract may play a role in its therapeutic effects. Understanding these components can be crucial for evaluating the overall efficacy and mechanism of action of the bioactive fraction.
Other Science Concepts:
Discover the significance of concepts within the article: 鈥�Clinical evaluation of terminalia belerica in diarrhoea鈥�. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic effect, Tropical diseases, Ayurvedic medicine, Inclusion criteria, Exclusion criteria, Clinical trial, Clinical evaluation, Placebo group, In vitro studies, Pathological investigations, Amoebic Dysentery, Bioactive fraction, Oral rehydration therapy, Patient compliance, Dysentery and Diarrhoea, Terminalia Belerica.