Anti � diabetic activity of the seed kernel of syzygium cumini linn
Journal name: Ancient Science of Life
Original article title: Anti � diabetic activity of the seed kernel of syzygium cumini linn
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:
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R. Bhaskaran Nair, G. Santhakumari
Ancient Science of Life:
(A quarterly multi-disciplinary scientific research journal in Ayurveda)
Full text available for: Anti � diabetic activity of the seed kernel of syzygium cumini linn
Year: 1986
Copyright (license): CC BY-NC-SA
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Summary of article contents:
Introduction
The study examines the anti-diabetic activity of the seed kernels of Syzygium cumini Linn, commonly known for its medicinal properties in Ayurvedic medicine. Historically, various parts of this plant, including its fruits, leaves, and seeds, have been utilized for treating ailments, specifically diabetes. Prior research highlighted the presence of a glycoside named jamboline in the seeds, which is believed to contribute to its hypoglycaemic effects. This study aims to assess the hypoglycaemic activity of an aqueous suspension of the dried seed kernels and to compare its efficacy with standard hypoglycaemic agents, Tolbutamide and Phenformin.
Efficacy of Syzygium cumini Seed Kernels
The investigation revealed that an optimal dose of 4 g/kg body weight of the seed kernel resulted in a significant reduction in blood sugar levels in rabbits, with a hypoglycaemic effect of 42.64% observed three hours after administration. This effect is comparable to that of Tolbutamide, which produced a reduction of 52.10% and demonstrated a more prolonged action. Additionally, when tested on alloxan-diabetic rats, the seed kernel produced a noteworthy decrease in blood sugar levels (17.04%), suggesting that it potentially acts through extra pancreatic mechanisms. This finding indicates that the active compounds in the seed kernels can effectively enhance insulin secretion or modulate glucose metabolism.
Conclusion
The research findings underscore the potential of Syzygium cumini seed kernels as a natural therapeutic agent for managing diabetes. Notably, the seeds exhibited a significant hypoglycaemic effect, particularly at the optimum dosage, and demonstrated mechanisms of action that could complement traditional hypoglycaemic medications. Further studies are warranted to fully understand the biochemical pathways involved and to explore the clinical applications of this plant material in diabetes management. The authors express gratitude for the financial support from the Central Council for Research in Ayurveda and Siddha, which facilitated this study.
FAQ section (important questions/answers):
What is the anti-diabetic activity studied in Syzygium cumini seed kernels?
The study evaluated the hypoglycaemic effects of aqueous suspensions of Syzygium cumini seed kernels at various doses, identifying a significant blood sugar reduction, particularly at 4 g/kg body weight.
How does Syzygium cumini compare to standard hypoglycaemic drugs?
The maximum hypoglycaemic effect of Syzygium cumini at 4 g/kg was 42.64%, compared to Tolbutamide's 52.10% and Phenformin's 25%, indicating it can lower blood sugar but not as effectively as the standard drugs.
What was the method used to test the seed kernels' effect?
Adult male rabbits were divided into groups and administered different doses of Syzygium cumini seed kernel aqueous suspension or standard drugs. Blood sugar levels were measured at set intervals after administration.
What were the findings regarding alloxan diabetic rats?
In alloxan diabetic rats, Syzygium cumini demonstrated a 17.04% reduction in blood sugar, indicating it may have an extra pancreatic action, as Tolbutamide did not show significant hypoglycaemic effects in these animals.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti � diabetic activity of the seed kernel of syzygium cumini linn�. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is a vital fluid in the body that carries oxygen, nutrients, and hormones to cells while removing waste products. In the context of the study, measuring blood sugar levels in animals is critical for evaluating the hypoglycemic effects of the tested substances, specifically indicating the efficacy of treatments for diabetes.
2) Sugar:
Sugar refers to simple carbohydrates that provide energy in the body. In this study, blood sugar levels are a primary focus, as they are a crucial indicator of diabetes management. The research examines how the seed kernel of Syzygium cumini affects these levels, revealing its potential as an anti-diabetic agent.
3) Drug:
A drug is a chemical substance used to diagnose, cure, or prevent disease. The study investigates the effects of S. cumini as a hypoglycemic drug compared to established medications like Tolbutamide and Phenformin. Understanding the action of these drugs helps inform treatment protocols for diabetes management.
4) Water:
Water is a universal solvent essential for life and often used as a control in experimental studies. Here, it serves as a baseline for comparing the effectiveness of the aqueous suspension of S. cumini seed kernels. Accurate water controls ensure reliable results by maintaining consistency in experimental conditions.
5) Activity:
Activity in a scientific context often refers to the biological or chemical effects a substance has. This study assesses the anti-diabetic activity of S. cumini seed kernels by measuring their impact on blood sugar levels, thus evaluating their potential therapeutic application for managing diabetes.
6) Syzygium cumini:
Syzygium cumini, also known as jambolan, is a medicinal plant whose seeds are studied for their hypoglycemic properties. The research focuses on its active components, including jamboline, and their effects on blood sugar regulation, thereby providing insight into traditional uses and potential health benefits.
7) Ayurveda (Ä€yurveda, Ayus-veda):
Ayurveda is an ancient system of medicine from India that promotes holistic health through natural remedies. The study references Ayurvedic practices, highlighting the traditional use of S. cumini for diabetes treatment, bridging historical practices with contemporary scientific investigation into its efficacy.
8) Gupta (GuptÄ):
Gupta refers to a researcher mentioned in the study, contributing to the body of knowledge regarding Syzygium cumini. This highlights the collaborative nature of scientific inquiry where multiple studies build upon each other to validate and expand understanding of medicinal plants and their pharmacological effects.
9) Pharmacological:
Pharmacological pertains to the study of drugs and their interactions with biological systems. This research is pharmacological in nature as it investigates how S. cumini kernel affects blood sugar levels in laboratory animals, contributing to the understanding of how plant-based substances can influence health.
10) Discussion:
Discussion in a research context involves interpreting the results, linking findings to previous research, and suggesting potential implications. In this study, the discussion section examines the significance of the results obtained and posits hypotheses about mechanisms of action, thereby placing findings in a broader context.
11) Himalaya (HimÄlaya, Hima-alaya):
The Himalaya refers to a major mountain range in Asia, significant for its biodiversity and medicinal plants. The reference to this region emphasizes the traditional ecological knowledge surrounding plants like S. cumini and the geographic sources of such herbal remedies used in Ayurvedic practices.
12) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing disease. This study contributes to the field of medicine by exploring the effects of traditional herbal remedies on diabetes treatment, aiming to integrate indigenous knowledge with modern scientific methods for improved health outcomes.
13) Shankara (Saá¹…kÄra, Saá¹…kara, ÅšÄṃkara, Åšaá¹…kara, Åšaṃkara, ÅšÄá¹…kara, SaṃkÄra, Saṃkara, Sham-kara):
Sankara likely refers to another contributing researcher cited in the study. This illustrates the importance of scholarly collaboration in health research, where diverse contributions can lead to comprehensive insights into the efficacy and mechanisms of herbal treatments in managing conditions like diabetes.
14) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge through testable explanations and predictions. This research combines traditional medicinal knowledge with scientific scrutiny, highlighting the importance of empirical studies in validating claims made about the therapeutic benefits of plants like S. cumini.
15) Siddha (SiddhÄ):
Siddha is another traditional system of medicine from South India, similar to Ayurveda, that utilizes a variety of medicinal plants. The reference to Siddha emphasizes the intersection of traditional healing practices with scientific research, illustrating a holistic approach to health and wellness through plant-based remedies.
16) Thirst:
Thirst refers to a physical sensation that indicates a need for hydration. In the context of diabetes, excessive thirst is a common symptom. The study's exploration of S. cumini aims to address this symptom, suggesting that effective management of blood sugar levels can alleviate such distressing manifestations.
17) Renu (Reṇu):
Renu refers to one of the researchers involved in the study, indicating the collaborative nature of scientific inquiry. The mention of Renu highlights the contribution of different individuals towards advancing the understanding of the medicinal properties of S. cumini and its practical applications in diabetes management.
Other Science Concepts:
Discover the significance of concepts within the article: �Anti � diabetic activity of the seed kernel of syzygium cumini linn�. Further sources in the context of Science might help you critically compare this page with similair documents:
Syzygium cumini, Therapeutic application, Ayurvedic medicine, Diabetes mellitus, Control group, Blood sugar level, Anti-diabetic activity, Hypoglycaemic effect, Insulin release, Chemical constituent, Alloxan-diabetic rats, Aqueous suspension, Diabetic animals.