Significance of Therapeutic indices
Therapeutic indices serve as a measure of the safety and efficacy of drugs by providing a comparison of effective versus toxic doses. They are particularly important for drugs with narrow therapeutic indices and can help assess the potency of drug analogs developed from natural prototypes. Additionally, therapeutic indices can reveal the range of effects exhibited by medicinal plants, highlighting their efficacy and safety for treating various health conditions.
Synonyms: Therapeutic ratio, Therapeutic window, Safety margin, Dose-response relationship
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The concept of Therapeutic indices in scientific sources
Therapeutic indices are crucial for assessing the safety and efficacy of medications, indicating the effective versus toxic dosage ratios of enantiomers and the effects of medicinal plants in treating specific health conditions.
From: World Journal of Pharmaceutical Research
(1) Ratios that indicate the safety and effectiveness of a drug, providing a measure of its potency when developed as an analog from natural prototypes.[1] (2) A measure of the safety and efficacy of a drug; Atrigel systems are beneficial for drugs with narrow therapeutic indices.[2] (3) The ratios that determine the range of effective dose versus toxic dose provided by different enantiomers.[3]
From: AYU (Journal of Research in Ayurveda)
(1) A range of effects or actions demonstrated by a medicinal plant, indicating its efficacy and safety in treating specific health conditions.[4]