Significance of Teratogenic effect
The teratogenic effect refers to the adverse impacts on fetal development caused by certain drugs, substances, or environmental factors during pregnancy. These effects can lead to developmental malformations or birth defects in the embryo or fetus. Examples of substances linked to teratogenic effects include specific medications like methotrexate and chloroquine, as well as high doses of saffron and other harmful agents. Understanding these risks is crucial for managing drug therapy and ensuring the safety of pregnant patients and their developing children.
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Teratogenic effect in scientific sources
The Teratogenic effect pertains to harmful impacts on fetal development from substances like drugs or alcohol, leading to birth defects or abnormal growth due to teratogenic agents, exemplified by Cyclophosphamide's influence on embryonic development.
From: The Malaysian Journal of Medical Sciences
(1) These are the harmful effects of a substance on the development of a foetus, and the study aimed to determine if the substance had any.[1] (2) There is no evidence of these with gadolinium administration, making it a safe option for the mother.[2] (3) Adverse effects on fetal development that can occur from the use of certain substances, including saffron at high doses during pregnancy.[3]