Significance of Preclinical testing
Preclinical testing is a critical phase of drug development that involves conducting experimental research primarily on animals or in vitro models to assess the safety and efficacy of new compounds before they proceed to human clinical trials. This stage is essential for understanding the pharmacokinetics and effectiveness of treatments, and it plays a significant role in evaluating various substances, including those derived from traditional medicine. Through these studies, researchers can ensure that potential drugs are safe for human use.
Synonyms: Preclinical evaluation, Preclinical research, Preclinical studies, Non-clinical testing, Laboratory testing, Experimental testing, Animal testing, In vitro testing, Experimental research
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The concept of Preclinical testing in scientific sources
Preclinical testing involves conducting experiments on animal models prior to clinical trials, aiming to evaluate the safety and efficacy of substances. This step is crucial for determining whether a treatment is viable for human testing.
From: World Journal of Pharmaceutical Research
(1) Experimental research carried out on animals or in vitro models to assess the safety and efficacy of compounds before human trials.[1] (2) Laboratory and animal studies conducted to evaluate the efficacy and safety of transferosomes before clinical trials in humans.[2] (3) Investigative work conducted prior to human clinical trials to ascertain the pharmacokinetics, efficacy, and safety of new drug formulations.[3] (4) The phase of drug development that involves testing drugs on laboratory animals before clinical trials in humans.[4] (5) Experiments conducted before clinical trials to evaluate the effects of substances in animal models to assess their safety and efficacy.[5]
From: Journal of Ayurveda and Integrative Medicine
(1) The stage of research that evaluates the efficacy and safety of treatments in models before moving to human trials; emphasized in assessing traditional medicine.[6]