Significance of Polymorphism
Polymorphism refers to the presence of two or more genetically different alleles at a locus within a population, which can significantly influence drug metabolism and individual responses. It encompasses genetic variations that affect drug efficacy, as well as the occurrence of substances in various crystalline forms, impacting their solubility and stability. This concept also addresses variations in DNA sequences that can alter gene function, potentially influencing health outcomes like cancer susceptibility and other conditions.
Synonyms: Variety, Diversity, Multiplicity, Adaptability, Variation, Flexibility
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The concept of Polymorphism in scientific sources
Polymorphism describes the presence of multiple forms within a population, whether in genetic alleles among Viola serpens, variations in species genetic markers, or diverse crystal arrangements influencing pharmaceutical properties.
From: The Malaysian Journal of Medical Sciences
(1) The existence of multiple forms of a gene or DNA sequence within a population, with D19S884 being a dinucleotide repeat polymorphism.[1] (2) This is the presence of genetic variation, like the rs13142920 in GPM6A, and is a key focus of the study to determine its connection to the risk of paranoid schizophrenia.[2] (3) The occurrence of multiple forms of a gene or trait in a population, and is associated with an increased risk of ischaemic stroke in the context of MMP genes.[3] (4) Variations in the DNA sequence among individuals, observed at specific positions in the HVS-I region.[4]