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Significance of Paracetamol induced toxicity

Paracetamol induced toxicity is a condition characterized by severe liver and kidney damage resulting from paracetamol administration. Studies in male Sprague Dawley rats and freshwater fish Labeo rohita have shown that this toxicity leads to elevated liver enzymes and oxidative stress. The formation of toxic metabolites is linked to this liver injury, which can be quantified by elevated serum biochemical markers. Additionally, paracetamol is used in research to model and investigate potential hepatoprotective activities of substances like Indigofera trifoliata.

Synonyms: Acetaminophen overdose, Paracetamol overdose, Acetaminophen toxicity

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The concept of Paracetamol induced toxicity in scientific sources

Science Books

Paracetamol induced toxicity describes severe liver and kidney damage from paracetamol administration, notably studied in male Sprague Dawley rats, leading to elevated liver enzyme levels indicative of liver impairment.

Significance in Scientific journals, articles, etc.:

From: World Journal of Pharmaceutical Research

(1) Hepatotoxicity that occurs as a result of exposure to high doses of paracetamol, which can lead to liver damage and dysfunction.[1] (2) Liver damage caused by the administration of paracetamol, used in this study to create a model for investigating the hepatoprotective activity of Indigofera trifoliata.[2] (3) A condition caused by the administration of paracetamol (acetaminophen), resulting in liver damage, characterized by elevated liver enzymes and oxidative stress in freshwater fish Labeo rohita.[3] (4) Liver damage or injury caused by the administration of paracetamol, leading to elevated serum biochemical markers.[4] (5) Liver damage that occurs as a result of administering paracetamol, which can lead to elevated levels of certain liver enzymes.[5]

From: Journal of Ayurveda and Integrative Medicine

(1) The damage caused to the liver and kidney due to the overdose of paracetamol, leading to significant biochemical and histopathological changes.[6] (2) Liver damage caused by the administration of paracetamol, which is linked to the formation of toxic metabolites and oxidative stress.[7]

This section includes scientific research in the field of healthcare, often involving traditional medicine systems such as Ayurveda, Unani, Siddha and Holistic health. It includes papers from scientific journals classified as either original, clinical or experimental research, review articles or case reports.