Significance of Nuclear factor-kappa B
Nuclear factor-kappa B is a significant protein complex that regulates the immune response and inflammation, impacting various health conditions, including liver diseases and cancers. It plays a crucial role in the immune response to infections and is involved in the survival of cancer cells. Activation of this transcription factor can be influenced by factors such as polydatin and green tea, highlighting its importance in therapeutic strategies against inflammation and cancer progression. Its involvement also extends to cardiovascular responses and periodontal disease.
Synonyms: Nf-kb, Transcription factor, Nf-kappab, Nf-kappa b, Nuclear factor-k b
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Nuclear factor-kappa B in scientific sources
Nuclear factor-kappa B is a vital protein complex that regulates immune responses and influences cancer progression. It is activated by reactive oxygen species and inflammatory cytokines, significantly contributing to pro-inflammatory responses and cardiac remodeling.
From: The Malaysian Journal of Medical Sciences
(1) This is a transcription factor composed of five polypeptide subunits, and it plays a critical role in the expression of cytokines involved in early osteoclast differentiation.[1] (2) This is a protein complex that plays a key role in regulating the immune response, and is involved in inflammatory pathways.[2] (3) A vital transcription factor involved in the immune response regulation, which can be activated by various stimuli, including TLR signaling.[3] (4) A protein complex that controls the transcription of DNA and plays a key role in regulating the immune response.[4]