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Significance of Mitochondrial dysfunction

Mitochondrial dysfunction refers to the impaired functioning of mitochondria, which affects energy production, leading to various health issues. This condition is linked to neurodegenerative diseases such as Parkinson's and Alzheimer's, where it contributes to neuronal damage and energy deficits. Mitochondrial dysfunction is characterized by reduced ATP generation and increased oxidative stress, which further exacerbates the progression of these diseases. Additionally, it can result from factors like glutamate receptor activation and mutations in nuclear or mitochondrial DNA.

Synonyms: Mitochondrial disorder

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The concept of Mitochondrial dysfunction in scientific sources

Science Books

Mitochondrial dysfunction involves abnormalities in mitochondria that can lead to energy deficits in motor neurons, increased reactive oxygen species in diseases like ALS and Parkinson's, and complications related to obesity, further exacerbated by environmental factors.

Significance in Scientific journals, articles, etc.:

From: The Malaysian Journal of Medical Sciences

(1) Mitochondrial dysfunction is caused by oxidative damage to mitochondrial DNA, and autophagy is important for proper renewal of mitochondria and maintenance of muscle mass.[1] (2) Mitochondrial dysfunction is believed to be caused by a complex interplay that causes Parkinson's disease, which also includes oxidative stress and apoptotic cell death.[2] (3) This is a condition where mitochondria do not function properly, and it is believed to be involved in the mechanism of insulin resistance and can be determined by changes in the size or number of these organelles.[3] (4) This is a result of the overloading of glutamate receptor activation by KA receptors, alongside the influx of cellular Ca 2+ and production of reactive oxygen species (ROS).[4] (5) Impairment in mitochondria function that affects energy metabolism and is linked to neurodegenerative diseases like Alzheimer's.[5]

This section includes scientific research in the field of healthcare, often involving traditional medicine systems such as Ayurveda, Unani, Siddha and Holistic health. It includes papers from scientific journals classified as either original, clinical or experimental research, review articles or case reports.