Significance of HLA-B 27
HLA-B 27 is a genetic marker closely linked to autoimmune diseases, particularly ankylosing spondylitis. Its presence is found in 90-95% of patients diagnosed with ankylosing spondylitis, making it a crucial marker for diagnosis. Individuals with HLA-B 27 have a greater predisposition to develop ankylosing spondylitis and related spondyloarthropathies, indicating a higher risk. Although it is not always required for diagnosis, HLA-B 27 serves as an important indicator of these conditions in the general population.
Synonyms: Histocompatibility antigen
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The concept of HLA-B 27 in scientific sources
HLA-B 27 is a specific human leukocyte antigen closely linked to ankylosing spondylitis, aiding in diagnosis and indicating a higher likelihood of developing the disease, although it is not essential for all diagnoses.
From: International Ayurvedic Medical Journal
(1) A genetic marker strongly associated with Ankylosing Spondylitis and other autoimmune diseases, indicating a potential predisposition to developing these conditions.[1] (2) A genetic marker associated with Ankylosing Spondylitis; its presence is found in significantly higher percentages in patients with the disease compared to the general population.[2] (3) HLA-B 27 is a genetic marker that shows a strong association with ankylosing spondylitis and other spondyloarthropathies.[3] (4) A human leucocyte antigen present in approximately 90-95% of Ankylosing Spondylitis patients, used as a marker in diagnosis.[4] (5) A genetic marker strongly associated with ankylosing spondylitis, where its presence indicates a higher likelihood of developing the disease, although it is not always necessary for diagnosis.[5]
From: Journal of Ayurveda and Holistic Medicine
(1) A specific human leukocyte antigen present in a high percentage of patients with ankylosing spondylitis, useful in diagnosing the condition.[6] (2) A genetic marker significantly associated with ankylosing spondylitis, common in patients diagnosed with the condition.[7]
From: World Journal of Pharmaceutical Research
(1) A human leucocyte antigen genetic marker strongly associated with ankylosing spondylitis, indicating a higher risk for the disease in those who possess it.[8]
From: Journal of Ayurveda and Integrative Medicine
(1) A genetic marker associated with autoimmune diseases, including axial spondyloarthritis, which may predispose individuals to drug reactions.[9]