Significance of Hirudin
Hirudin is a bioactive anticoagulant found in leech saliva, renowned for its ability to inhibit blood coagulation by binding to thrombin. It prevents blood clotting during leech feeding and promotes healing in wounds. Hirudin is noted for its superior anticoagulant properties compared to heparin and plays a significant role in therapeutic applications, such as Jalaukavacharana. Additionally, it shows promise in treating cardiovascular conditions by facilitating blood flow and exhibiting thrombolytic and anti-inflammatory effects.
Synonyms: Anticoagulant, Blood thinner, Antithrombotic agent
The below excerpts are indicatory and do represent direct quotations or translations. It is your responsibility to fact check each reference.
The concept of Hirudin in scientific sources
Hirudin is a crucial anticoagulant substance derived from leech saliva, which aids in preventing blood clotting, reducing inflammation, and enhancing healing by inhibiting specific inflammatory proteins during leech therapy.
From: World Journal of Pharmaceutical Research
(1) A protein present in leech saliva that acts as an anticoagulant by inhibiting thrombin, playing a significant role in the leech's therapeutic effects.[1] (2) Hirudin is a bioactive constituent found in the saliva of leeches that serves as an anticoagulant, playing a beneficial role in Jalaukavacharana.[2] (3) A specific anticoagulant found in leech saliva that inhibits blood coagulation by binding to thrombin.[3] (4) An anticoagulant substance found in leech saliva that inhibits thrombin and is useful in treating cardiovascular conditions.[4] (5) A substance secreted by the saliva of the Jalauka (leech) that has thrombolytic, anticoagulant, and anti-inflammatory properties.[5]
From: International Ayurvedic Medical Journal
(1) A natural anticoagulant found in leech saliva, known for its ability to prevent blood clotting and promote healing in wounds.[6] (2) An enzyme found in leech saliva that acts as an anticoagulant, enhancing the therapeutic effects in leech therapy.[7] (3) An enzyme found in leech saliva that acts as an anticoagulant, playing a crucial role in the therapeutic effects of Jalaukaavcharan.[8] (4) A substance recognized in leech saliva, used as an anticoagulant in medical treatments.[9] (5) A specific thrombin inhibitor isolated from leech saliva; effective in clinical treatments to prevent clot formation.[10]
From: Journal of Ayurveda and Holistic Medicine
(1) An important component found in leech saliva that acts as an anti-coagulant, helping to prevent blood clotting during leech therapy.[11] (2) An anticoagulant substance found in leech saliva that prevents blood coagulation at the site of the bite.[12]
From: Ancient Science of Life
(1) A potent anticoagulant found in leech saliva that binds to thrombin, preventing blood clot formation and aiding in the treatment of vascular conditions.[13]