Significance of DNA vaccine
DNA vaccine refers to a type of vaccine that employs DNA encoding specific antigens to trigger an immune response. This innovative approach is used in malaria research and involves genetically engineered plasmids to activate both cellular and humoral immunity against various diseases, including cancer and viruses like Ebola. DNA vaccines are designed to offer immune protection by utilizing portions of a germ's DNA, providing a safe method to induce a protective response without causing illness.
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The concept of DNA vaccine in scientific sources
DNA vaccines utilize plasmid DNA to provoke immune responses against specific pathogens, employing genetically engineered DNA plasmids that encode antigens to effectively stimulate the host's immune system.
From: The Malaysian Journal of Medical Sciences
(1) These consist of a closed circular bacterial plasmid that encodes the antigen of interest under the control of a strong eukaryotic promoter, after transfection.[1] (2) The vaccine prototype is currently being tested as a DNA vaccine delivery vector for immunisation against COVID-19 and tuberculosis, according to the provided information.[2] (3) A vaccine that uses DNA to stimulate an immune response, and in this context, the recombinant plasmid containing the TSA gene is considered a potential one.[3] (4) This type of vaccine uses DNA encoding a specific antigen to stimulate an immune response and is used in malaria research.[4] (5) Vaccines that use genetically engineered DNA to induce an immune response against viruses such as Ebola.[5]