Significance of Binding energy
Binding energy is a crucial measure of the stability and strength of interactions between a ligand and its target protein. It indicates how strongly a compound is held together and is essential in assessing the efficacy of drug interactions. Lower binding energy values signify stronger interactions and higher binding affinity. This parameter is typically reported in kcal/mol and is instrumental in evaluating the effectiveness of compounds during docking studies, reflecting the potential therapeutic impact of drug candidates.
Synonyms: Interaction energy, Cohesive energy
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The concept of Binding energy in scientific sources
Binding energy quantifies the strength of interactions between a drug and its target protein. Lower binding energy values suggest higher affinity and potential efficacy for therapeutic applications, informing drug effectiveness and development.
From: The Malaysian Journal of Medical Sciences
(1) The lowest binding energy pose with an R-isomer of carvone demonstrated an energy of �5.03 Kcal/mol, forming a hydrogen bond interaction with Lys692 and Lys735, as well as several hydrophobic interactions with Val683, Leu853 and Leu857, as depicted in Figure 6B, describing a measurement.[1] (2) Binding energy is the energy of the bond that formed between the ligand and the target receptor, which helps determine the effectiveness of a substance.[2] (3) The energy associated with the interactions between Gallic Acid and apoptotic factors, indicating the strength of their binding.[3]