Significance of Acute phase reactant
Acute phase reactants are substances in the blood that increase in response to inflammation, playing a critical role in diagnosing and monitoring various conditions, including rheumatoid arthritis and infections. Key examples include C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which serve as markers for disease activity and inflammation levels. These proteins, produced primarily in the liver, are valuable in assessing chronic diseases and the effectiveness of treatments, indicating significant physiological changes during inflammatory states.
Synonyms: -inflammatory marker, Serum protein, Acute phase protein, Biomarker
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The concept of Acute phase reactant in scientific sources
Acute phase reactant signifies proteins like ferritin and ProCT that rise during inflammation, serving as diagnostic markers for chronic diseases and infections, reflecting the body's early non-specific response to injury or inflammation.
From: The Malaysian Journal of Medical Sciences
(1) These are reduced within 24 hours after treatment with intravenous immunoglobulin in patients with Kawasaki disease, indicating the effectiveness of the treatment.[1] (2) Types of proteins in the blood that increase in concentration during inflammation, including C-reactive protein, indicating SICH's systematic response.[2] (3) Markers like ESR used to measure disease activity in rheumatoid arthritis.[3] (4) CRP is a positive acute phase reactant elevated in both acute and chronic inflammatory conditions, with a half-life of 19 hours.[4] (5) Substances in the blood that increase in response to inflammation, such as CRP and ESR, used for diagnosing infections.[5]